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# Poised cell circuits in human skin are activated in disease
# Developmental cell programs are co-opted in inflammatory skin diseases

This repository contains code used for the analysis of the Human Cell Atlas Skin samples bioRxiv *preprint doi: https://doi.org/10.1101/2020.11.05.369363.*
This repository contains code used for the analysis of the Human Cell Atlas Skin paper published in Science Jan 2021 DOI: 10.1126/science.aba6500

## Data
Datasets analysed include: 10X data (Healthy adult Skin, PS skin, AD skin, fetal Skin), IHC for healthy and diseased skin, SS2 data, and healthy skin BCR-/TCR-enriched VDJ data.

To quickly browse our data, our online webportal resource may be accessed via (https://developmentcellatlas.ncl.ac.uk/)

Data is available as a h5ad file at 10.5281/zenodo.4453749
Code is also available on Zenodo 10.5281/zenodo.4249674

Data is available as a h5ad file at 10.5281/zenodo.4569496

Raw data is available on ArrayExpress www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-8142

## Analysis workflows
Cellranger count matrix files for Healthy, AD and PS skin 10X data were loaded into one object as described in https://github.com/haniffalab/FCA_liver for downstream analysis.
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