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bugfix from upstream viral-pipelines #62

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Aug 19, 2021
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dpark01
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@dpark01 dpark01 commented Aug 19, 2021

Introducing a bugfix from viral-pipelines. This version of wf_sarscov2_nextstrain_modified (and therefore wf_titan_augur_run) appear to have inherited a bug from upstream in which the augur refine and augur ancestral steps were running on unmasked input instead of masked input (like augur tree was properly doing). This PR fixes the workflow so that all downstream augur steps are using the masked multiple sequence alignment (fasta). Unaddressed, this bug causes weird inconsistencies sometimes where masked SNPs can create phantom nodes in the tree (see partial discussion on SPHERES slack, though most of this was discussed/debugged elsewhere).

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dpark01 commented Aug 19, 2021

bug found by @tsibley

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Oh, wow. Thanks for the heads up and submitting the PR!

@kevinlibuit kevinlibuit merged commit a352540 into theiagen:main Aug 19, 2021
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