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When sequence IDs are numbers, pandas reads index as int64 dtype (even if you specify dtype in read_table() - index_col=0 overrides it and the index is read as int64 no matter what). fasta sequence IDs are always read as strings, and so all calls to "seq_id in seq_table.index" returns False (e.g. line 129:
missing_ids = [seq_id for seq_id in self.seq_abunds.index if seq_id not in self.records]
).Looks like this is still an open issue: pandas-dev/pandas#9435