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Sup was kind of slow, and sometimes took a few seconds to open up an (albeit large) email thread. Running perftools.rb on it to see what was taking up so much time, shows that surprisingly ~ 60% of wallclock time is spent in GC.
Tuning Ruby's GC not to run so often fixed this, resulting in GC now taking only 13% of wall clock time, as well as a faster sup. The settings I used are: