ACMG classification adjustments

• Mechanisms of disease for cancer susceptibility genes (GoF vs. LoF) retrieved from Maxwell et al., Am J Hum Genet, 2016
• Exceptions for HFE/SERPINA1 wrt. high population MAF (BA1)
• Threshold for genes with "primarily truncations" set to 90% pathogenic truncations (BP1)
• Consider only pathogenic ClinVar variants (not likely pathogenic) when checking for novel peptide changes at pathogenic loci (PS1/PM5)