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Way better than to configure xrandr: pympress
Get a list of your output devices
$ xrandr --listmonitors
Configure Displays accordingly to the listed aspect ratios
xrandr --output eDP1 --mode 1920x1080 --output HDMI1 --mode 1280x1024
scale output of the selected device to show only region of interest For details see also PracTeX Journal.
xrandr --output HDMI1 --mode 1280x1024 --scale 0.75x0.75 --pos 0x112