[ENH] Adds abagen.correct for postprocessing
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New function for correcting distance-dependent spatial effects from correlated gene expression array
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Codecov Report
@@ Coverage Diff @@
## master #20 +/- ##
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+ Coverage 97.59% 97.76% +0.17%
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Files 12 14 +2
Lines 498 581 +83
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+ Hits 486 568 +82
- Misses 12 13 +1
Continue to review full report at Codecov.
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Adds function `gene_stability()` in `abagen.correct` for removing genes that have a differential stability below a given threshold across donors.
Adds `return_donors` argument to `get_expression_data`, which will return a list of expression dataframes rather than a single unit. Useful if users want to post-process the data to select genes with, e.g., high differential stability.
The `remove_distance()` function in `abagen.correct` previously considered cortical-subcortical and subcortical-cortical connections separately when regressing distance, despite an inability to appreciate directed connections. This patch ensures that distance is regressed from all cortical-subcortical connections regardless of directionality at the same time.
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Adds functions for correcting distance-dependent spatial effect of correlated gene expression arrays (
abagen.correct.remove_distance()) and for discard genes that do not have a high differential stability across donors (abagen.correct.keep_stable_genes()).The latter function required adding the ability to return donor-level expression arrays from
abagen.get_expression_data(), so this closes #9.