Repositories list

• rSharp

  Public
  R package for communication with .NET Core

  C#

  •

  GNU General Public License v2.0

  •0•1•29•0•Updated Nov 27, 2024Nov 27, 2024

• PK-Sim

  Public
  PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

  suite-componentspk-sim

  C#

  •

  Other

  •51•107•403•0•Updated Nov 27, 2024Nov 27, 2024

• MoBi

  Public
  MoBi® is a software tool for multiscale physiological modeling and simulation

  suite-componentsmobi

  C#

  •

  Other

  •10•31•243•2•Updated Nov 27, 2024Nov 27, 2024

• RE-Test-Reports

  Public
  Assess consistency of simple reports generated using `{ospsuite.reportingengine}` package

  R

  •1•1•2•0•Updated Nov 26, 2024Nov 26, 2024

• OSPSuite.Core

  Public
  Core functionalities of the Open Systems Pharmacology Suite

  suite-components

  C#

  •

  Other

  •8•5•121•1•Updated Nov 26, 2024Nov 26, 2024

• Qualification-DDI-P-gp

  Public
  Qualification of OSP platform for P-gp-mediated DDI

  R

  •0•0•0•0•Updated Nov 26, 2024Nov 26, 2024

• Oral-PBBM-Workflow

  Public
  PBBM workflow for orally administered drug products presented by Vrenken et al. (2025)

  0•0•0•0•Updated Nov 26, 2024Nov 26, 2024

• OSPSuite-R

  Public
  R package for the OSPSuite

  R

  •

  Other

  •12•29•158•1•Updated Nov 22, 2024Nov 22, 2024

• Rifampicin-Digoxin-DDI

  Public
  Modeling of published clinical Rifampicin-Digoxin-DDI studies for model evaluation

  ddipbpkosp-model+ 1pk-sim

  1•0•1•0•Updated Nov 21, 2024Nov 21, 2024

• OSPSuite.GlobalSensitivity

  Public
  R

  •

  Other

  •1•0•5•0•Updated Nov 21, 2024Nov 21, 2024

• OSPSuite.RUtils

  Public
  Utility functions for Open Systems Pharmacology R packages

  R

  •

  GNU General Public License v2.0

  •3•2•11•1•Updated Nov 19, 2024Nov 19, 2024

• OSPSuite.SimModel

  Public
  Calculation engine for models built with PK-Sim® or MoBi®

  suite-components

  C++

  •

  Other

  •3•4•16•1•Updated Nov 14, 2024Nov 14, 2024

• OSMOSES

  Public
  Open-Source MOdeling framework for automated quality control and management of complex life Science systEms modelS (OSMOSES)

  Other

  •0•0•9•0•Updated Nov 14, 2024Nov 14, 2024

• OSPSuite.ReportingEngine

  Public
  R implementation of the reporting engine

  R

  •

  Other

  •5•5•59•0•Updated Nov 13, 2024Nov 13, 2024

• Valproic-Acid

  Public
  Whole-body PBPK model of valproic acid including non-linear binding with albumin in adults, children and children with hypoalbuminemia.

  pbpkosp-modelpediatrics+ 1non-linear-binding

  R

  •0•0•0•0•Updated Nov 5, 2024Nov 5, 2024

• open-systems-pharmacology.github.io

  Public
  Open Systems Pharmacology Website (www.open-systems-pharmacology.org)

  SCSS

  •4•1•7•1•Updated Oct 28, 2024Oct 28, 2024

• OSPSuite.Addins

  Public
  RStudio Addins to work with OSPSuite framework

  R

  •

  Other

  •1•0•0•0•Updated Oct 24, 2024Oct 24, 2024

• Coproporphyrin-I

  Public
  ddiosp-model

  R

  •1•0•0•1•Updated Oct 23, 2024Oct 23, 2024

• Propofol-Model

  Public
  Whole-body pbpbk model of Propofol

  pbpkosp-modelpk-sim

  R

  •1•0•1•0•Updated Oct 22, 2024Oct 22, 2024

• Verapamil-Model

  Public
  Verapamil PBPK model

  pbpkosp-modelpk-sim

  R

  •4•1•0•0•Updated Oct 16, 2024Oct 16, 2024

• Verapamil-Digoxin-DDI

  Public
  Modeling of published clinical Verapamil-Digoxin-DDI studies for model evaluation

  1•0•0•0•Updated Oct 16, 2024Oct 16, 2024

• Suite

  Public
  Open Systems Pharmacology Suite Setup

  suite-components

  Rich Text Format

  •

  Other

  •28•110•14•0•Updated Oct 6, 2024Oct 6, 2024

• docs

  Public
  Open Systems Pharmacology - Live Documentation

  HTML

  •

  Other

  •17•9•56•0•Updated Oct 4, 2024Oct 4, 2024

• OSPSuite.Plots

  Public
  Figures and dependent tables which are used by R packages in the Open Systems Pharmacology ecosystem

  R

  •

  Other

  •3•2•7•0•Updated Oct 4, 2024Oct 4, 2024

• Workflows

  Public
  Reusable workflows (e.g. GitHub Actions) which can be used in any OSP repository

  4•1•3•0•Updated Oct 3, 2024Oct 3, 2024

• TLF-Library

  Public
  TLF Library implementation in R

  R

  •

  Other

  •6•9•79•0•Updated Sep 25, 2024Sep 25, 2024

• Clarithromycin-Digoxin-DDI

  Public
  Modeling of published clinical Clarithromycin-Digoxin-DDI studies for model evaluation

  ddipbpkosp-model+ 1pk-sim

  4•0•1•0•Updated Sep 23, 2024Sep 23, 2024

• Rifampicin-Model

  Public
  Whole-body PBPK model of rifampicin as CYP3A4 and P-gp DDI perpetrator drug

  ddipbpkosp-model+ 1pk-sim

  MATLAB

  •4•0•1•0•Updated Sep 23, 2024Sep 23, 2024

• Digoxin-Model

  Public
  Whole-body PBPK model of digoxin as P-gp DDI victim drug

  ddipbpkosp-model+ 1pk-sim

  R

  •4•7•1•0•Updated Sep 23, 2024Sep 23, 2024

• Itraconazole-Digoxin-DDI

  Public
  Modeling of published clinical Itraconazole-Digoxin-DDI studies for model evaluation

  ddipbpkosp-model+ 1pk-sim

  3•1•1•0•Updated Sep 20, 2024Sep 20, 2024