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TuomasBorman committed Feb 10, 2025
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6 changes: 4 additions & 2 deletions DESCRIPTION
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Package: OMA
Title: Orchestrating Microbiome Analysis with Bioconductor
Version: 0.98.35
Date: 2025-02-05
Version: 0.98.36
Date: 2025-02-10
Authors@R:
c(
person(given = "Tuomas", family = "Borman", role = c("aut", "cre"), email = "[email protected]", comment = c(ORCID = "0000-0002-8563-8884")),
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factoextra,
fido,
forcats,
ggdag,
ggplot2,
ggpubr,
ggtree,
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IntegratedLearner,
knitr,
maaslin3,
mediation,
mia,
miaTime,
miaViz,
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11 changes: 6 additions & 5 deletions inst/pages/mediation.qmd
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Expand Up @@ -115,9 +115,9 @@ by the microbiome is investigated in 3 different steps:

First, we ask whether alpha diversity mediates the effect of living environment
on BMI. Using the `getMediation` function, the variables X, Y and M are
specified with the arguments `treatment`, `outcome` and `mediator`, respectively.
We control for sex and age and limit comparisons to two nationality groups,
Central Europeans (control) vs. Scandinavians (treatment).
specified with the arguments `treatment`, `outcome` and `mediator`,
respectively. We control for sex and age and limit comparisons to two
nationality groups, Central Europeans (control) vs. Scandinavians (treatment).

```{r}
#| label: mediation3
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become the golden standard in microbiome data analysis, mainly because the
available approaches can only partially accommodate for the specific properties
of microbiome data, such as compositionality, sparsity and its hierarchical
structure. While this chapter proposed a standard approach to mediation analysis,
in the future fine-tuned solutions for the microbiome may also become common.
structure. While this chapter proposed a standard approach to mediation
analysis, in the future fine-tuned solutions for the microbiome may also become
common.

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