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better formatting in arXiv; change to abstract
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lh3 committed May 26, 2013
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\section{Summary:} BWA-MEM is a new alignment algorithm for aligning sequence
reads or assembly contigs against a large reference genome such as human.
It automatically chooses between local and end-to-end alignments, supports
paired-end reads and reports multiple local hits. The algorithm is robust to
paired-end reads and performs chimeric alignment. The algorithm is robust to
sequencing errors and applicable to a wide range of sequence lengths from 70bp
to a few megabases. For mapping 100bp sequences, BWA-MEM shows better
performance than several state-of-art read aligners to date.
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large-scale NGS data. Fast moving NGS technologies keep pressing for the
development of new alignment algorithms.

In this background, a few long-read alignment algorithms, including
BWA-SW~\citep{Li:2010fk}, Bowtie2~\citep{Langmead:2012fk},
In this background, a few long-read alignment algorithms, notably including
BWA-SW~\citep{Li:2010fk}, Bowtie2 \citep{Langmead:2012fk},
Cushaw2~\citep{Liu:2012uq} and GEM~\citep{Marco-Sola:2012kx}, have been
developed. However, they all have some weakness. BWA-SW is slower than bowtie2
for 100bp reads at a comparable accuracy and less accurate then Cushaw2 at a
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