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unable to access index for repository https://bioconductor.org/packages/3.20/bioc/bin/macosx/big-sur-arm64/contrib/4.5:
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pkg-config 0.29.2_3 is already installed and up-to-date.
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HOMEBREW_NO_INSTALLED_DEPENDENTS_CHECK is set: not checking for outdated
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unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.5:
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harfbuzz 8.5.0 is already installed and up-to-date.
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pkg-config 0.29.2_3 is already installed and up-to-date.
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cairo 1.18.0 is already installed and up-to-date.
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libpng 1.6.43 is already installed and up-to-date.
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giflib 5.2.2 is already installed and up-to-date.
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