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<header id="title-block-header">
<h1 class="title">Open collaborative writing with Manubot</h1>
</header>
<p><small><em> This manuscript (<a href="https://greenelab.github.io/meta-review/v/95da0bdf3063b5a470f567f5df8f5e33e1823647/">permalink</a>) was automatically generated from <a href="https://github.com/greenelab/meta-review/tree/95da0bdf3063b5a470f567f5df8f5e33e1823647">greenelab/meta-review@95da0bd</a> on June 3, 2019. </em></small></p>
<p><small><em> This manuscript (<a href="https://greenelab.github.io/meta-review/v/362b839108fdcb109ede7dc29a2492303cec62fe/">permalink</a>) was automatically generated from <a href="https://github.com/greenelab/meta-review/tree/362b839108fdcb109ede7dc29a2492303cec62fe">greenelab/meta-review@362b839</a> on June 3, 2019. </em></small></p>
<h2 id="authors">Authors</h2>
<ul>
<li><p><strong>Daniel S. Himmelstein</strong> <sup><a href="#correspondence"></a></sup><br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0002-3012-7446">0000-0002-3012-7446</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/dhimmel">dhimmel</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/dhimmel">dhimmel</a><br> <small> Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania </small></p></li>
<li><p><strong>Vincent Rubinetti</strong> <br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0002-4655-3773">0000-0002-4655-3773</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/vincerubinetti">vincerubinetti</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/vincerubinetti">vincerubinetti</a><br> <small> Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania </small></p></li>
<li><p><strong>David R. Slochower</strong> <br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0003-3928-5050">0000-0003-3928-5050</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/slochower">slochower</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/drslochower">drslochower</a><br> <small> Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego </small></p></li>
<li><p><strong>Dongbo Hu</strong> <br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0003-2606-3969">0000-0003-2606-3969</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/dongbohu">dongbohu</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/dongbohu">dongbohu</a><br> <small> Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania </small></p></li>
<li><p><strong>Venkat S. Malladi</strong> <br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0002-0144-0564">0000-0002-0144-0564</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/vsmalladi">vsmalladi</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/katatonikkat">katatonikkat</a><br> <small> Department of Bioinformatics, University of Texas Southwestern Medical Center; Bioinformatics Core Facility, University of Texas Southwestern Medical Center </small></p></li>
<li><p><strong>Casey S. Greene</strong> <br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0001-8713-9213">0000-0001-8713-9213</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/cgreene">cgreene</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/GreeneScientist">GreeneScientist</a><br> <small> Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania </small></p></li>
<li><p><strong>Anthony Gitter</strong> <sup><a href="#correspondence"></a></sup><br> <img src="images/orcid.svg" alt="ORCID icon" class="inline_icon" /> <a href="https://orcid.org/0000-0002-5324-9833">0000-0002-5324-9833</a> · <img src="images/github.svg" alt="GitHub icon" class="inline_icon" /> <a href="https://github.com/agitter">agitter</a> · <img src="images/twitter.svg" alt="Twitter icon" class="inline_icon" /> <a href="https://twitter.com/anthonygitter">anthonygitter</a><br> <small> Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison; Morgridge Institute for Research </small></p></li>
</ul>
<!-- commented out for https://github.com/greenelab/meta-review/issues/230
+ **Daniel S. Himmelstein** ^[✉](#correspondence)^<br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0002-3012-7446](https://orcid.org/0000-0002-3012-7446)
· ![GitHub icon](images/github.svg){.inline_icon}
[dhimmel](https://github.com/dhimmel)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[dhimmel](https://twitter.com/dhimmel)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>
+ **Vincent Rubinetti** <br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0002-4655-3773](https://orcid.org/0000-0002-4655-3773)
· ![GitHub icon](images/github.svg){.inline_icon}
[vincerubinetti](https://github.com/vincerubinetti)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[vincerubinetti](https://twitter.com/vincerubinetti)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>
+ **David R. Slochower** <br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0003-3928-5050](https://orcid.org/0000-0003-3928-5050)
· ![GitHub icon](images/github.svg){.inline_icon}
[slochower](https://github.com/slochower)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[drslochower](https://twitter.com/drslochower)<br>
<small>
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, San Diego, United States of America
</small>
+ **Dongbo Hu** <br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0003-2606-3969](https://orcid.org/0000-0003-2606-3969)
· ![GitHub icon](images/github.svg){.inline_icon}
[dongbohu](https://github.com/dongbohu)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[dongbohu](https://twitter.com/dongbohu)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>
+ **Venkat S. Malladi** <br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0002-0144-0564](https://orcid.org/0000-0002-0144-0564)
· ![GitHub icon](images/github.svg){.inline_icon}
[vsmalladi](https://github.com/vsmalladi)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[katatonikkat](https://twitter.com/katatonikkat)<br>
<small>
Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America; Bioinformatics Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
</small>
+ **Casey S. Greene** <br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0001-8713-9213](https://orcid.org/0000-0001-8713-9213)
· ![GitHub icon](images/github.svg){.inline_icon}
[cgreene](https://github.com/cgreene)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[GreeneScientist](https://twitter.com/GreeneScientist)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>
+ **Anthony Gitter** ^[✉](#correspondence)^<br>
![ORCID icon](images/orcid.svg){.inline_icon}
[0000-0002-5324-9833](https://orcid.org/0000-0002-5324-9833)
· ![GitHub icon](images/github.svg){.inline_icon}
[agitter](https://github.com/agitter)
· ![Twitter icon](images/twitter.svg){.inline_icon}
[anthonygitter](https://twitter.com/anthonygitter)<br>
<small>
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Morgridge Institute for Research, Madison, Wisconsin, United States of America
</small>
::: {#correspondence}
✉ — correspondence preferred via [GitHub Issues](https://github.com/greenelab/meta-review/issues).
Otherwise, address correspondence to <[email protected]> and <[email protected]>.
:::
-->
<p>Daniel S. Himmelstein<sup>1<a href="#correspondence">*</a></sup>, Vincent Rubinetti<sup>1</sup>, David R. Slochower<sup>2</sup>, Dongbo Hu<sup>1</sup>, Venkat S. Malladi<sup>3,4</sup>, Casey S. Greene<sup>1</sup>, Anthony Gitter<sup>5,6<a href="#correspondence">*</a></sup></p>
<ol type="1">
<li>Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</li>
<li>Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, San Diego, United States of America</li>
<li>Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America</li>
<li>Bioinformatics Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America</li>
<li>Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America</li>
<li>Morgridge Institute for Research, Madison, Wisconsin, United States of America</li>
</ol>
<div id="correspondence">
<p> — correspondence preferred via <a href="https://github.com/greenelab/meta-review/issues">GitHub Issues</a>. Otherwise, address correspondence to <a href="mailto:[email protected]" class="email">[email protected]</a> and <a href="mailto:[email protected]" class="email">[email protected]</a>.</p>
<p>* — correspondence preferred via <a href="https://github.com/greenelab/meta-review/issues">GitHub Issues</a>. Otherwise, address correspondence to <a href="mailto:[email protected]" class="email">[email protected]</a> and <a href="mailto:[email protected]" class="email">[email protected]</a>.</p>
</div>
<h2 id="abstract" class="page_break_before">Abstract</h2>
<p>Open, collaborative research is a powerful paradigm that can immensely strengthen the scientific process by integrating broad and diverse expertise. However, traditional research and multi-author writing processes break down at scale. We present new software named Manubot, available at <a href="https://manubot.org" class="uri">https://manubot.org</a>, to address the challenges of open scholarly writing. Manubot adopts the contribution workflow used by many large-scale open source software projects to enable collaborative authoring of scholarly manuscripts. With Manubot, manuscripts are written in Markdown and stored in a Git repository to precisely track changes over time. By hosting manuscript repositories publicly, such as on GitHub, multiple authors can simultaneously propose and review changes. A cloud service automatically evaluates proposed changes to catch errors. Publication with Manubot is continuous: When a manuscript’s source changes, the rendered outputs are rebuilt and republished to a web page. Manubot automates bibliographic tasks by implementing citation by identifier, where users cite persistent identifiers (e.g. DOIs, PubMed IDs, ISBNs, URLs), whose metadata is then retrieved and converted to a user-specified style. Manubot modernizes publishing to align with the ideals of open science by making it transparent, reproducible, immediate, versioned, collaborative, and free of charge.</p>
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<small><em>
This manuscript
([permalink](https://greenelab.github.io/meta-review/v/95da0bdf3063b5a470f567f5df8f5e33e1823647/))
([permalink](https://greenelab.github.io/meta-review/v/362b839108fdcb109ede7dc29a2492303cec62fe/))
was automatically generated
from [greenelab/meta-review@95da0bd](https://github.com/greenelab/meta-review/tree/95da0bdf3063b5a470f567f5df8f5e33e1823647)
from [greenelab/meta-review@362b839](https://github.com/greenelab/meta-review/tree/362b839108fdcb109ede7dc29a2492303cec62fe)
on June 3, 2019.
</em></small>

## Authors

<!-- commented out for https://github.com/greenelab/meta-review/issues/230


+ **Daniel S. Himmelstein** ^[✉](#correspondence)^<br>
Expand All @@ -50,7 +51,7 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[dhimmel](https://twitter.com/dhimmel)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>

+ **Vincent Rubinetti** <br>
Expand All @@ -61,7 +62,7 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[vincerubinetti](https://twitter.com/vincerubinetti)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>

+ **David R. Slochower** <br>
Expand All @@ -72,7 +73,7 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[drslochower](https://twitter.com/drslochower)<br>
<small>
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, San Diego, United States of America
</small>

+ **Dongbo Hu** <br>
Expand All @@ -83,7 +84,7 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[dongbohu](https://twitter.com/dongbohu)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>

+ **Venkat S. Malladi** <br>
Expand All @@ -94,7 +95,7 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[katatonikkat](https://twitter.com/katatonikkat)<br>
<small>
Department of Bioinformatics, University of Texas Southwestern Medical Center; Bioinformatics Core Facility, University of Texas Southwestern Medical Center
Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America; Bioinformatics Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
</small>

+ **Casey S. Greene** <br>
Expand All @@ -105,7 +106,7 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[GreeneScientist](https://twitter.com/GreeneScientist)<br>
<small>
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
</small>

+ **Anthony Gitter** ^[✉](#correspondence)^<br>
Expand All @@ -116,14 +117,40 @@ on June 3, 2019.
· ![Twitter icon](images/twitter.svg){.inline_icon}
[anthonygitter](https://twitter.com/anthonygitter)<br>
<small>
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison; Morgridge Institute for Research
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Morgridge Institute for Research, Madison, Wisconsin, United States of America
</small>


::: {#correspondence}
✉ — correspondence preferred via [GitHub Issues](https://github.com/greenelab/meta-review/issues).
Otherwise, address correspondence to <[email protected]> and <[email protected]>.
:::
-->



Daniel S. Himmelstein^1[*](#correspondence)^,
Vincent Rubinetti^1^,
David R. Slochower^2^,
Dongbo Hu^1^,
Venkat S. Malladi^3,4^,
Casey S. Greene^1^,
Anthony Gitter^5,6[*](#correspondence)^



1. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, San Diego, United States of America
3. Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
4. Bioinformatics Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
5. Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
6. Morgridge Institute for Research, Madison, Wisconsin, United States of America


::: {#correspondence}
\* — correspondence preferred via [GitHub Issues](https://github.com/greenelab/meta-review/issues).
Otherwise, address correspondence to <[email protected]> and <[email protected]>.
:::


## Abstract {.page_break_before}
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