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Adaptation of the BEELINE single-cell GRN benchmarking framework.

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BEELINE benchmarking of Model-X knockoffs

We made minimal modifications to BEELINE in order to benchmark various model-X knockoffs.

Our changes:

  • evaluate multiple parameter settings of the same model (issue here)
  • add a knockoff-based network inference method
  • add datasets with protein concentration and RNA production rate revealed (small modification of BoolODE)
  • benchmark FDR and undirected FDR in addition to AUPR et cetera
  • Add an R script for the final plots

To run our experiments, use test_knockoffs.sh. For more info about the project, see out project main repo. For more info about BEELINE, see the original. To run our experiments:

  • Install Docker and Conda
  • Set up Docker images with ./initialize.sh
  • Set up the BEELINE conda environment via setupAnacondaVENV.sh
  • Run test_knockoffs.sh

This will place all the figures in the main directory.

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Adaptation of the BEELINE single-cell GRN benchmarking framework.

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