KP.2.3 + S:S31del branch with N:H145Y + S:K679R + ORF1a:T2016K (239 in 12 countries) + Branch with S:G184S (14) and a Branch with ORF1a:S944L + S:E1202G (26)

[Fearuncle]

from: sars-cov-2-variants/lineage-proposals#1603

tree: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_43792_cbe980.json?f_userOrOld=uploaded%20sample

Query: C6312A, T19449C, A23598G, C28706T

Query with S:G184S: G22112A,C28706T, C6312A

Query with S:E1202G and ORF1a:S944L: C3096T, A25167G, C28706T

[Over-There-Is]

There is a subbranch with S:G184S. I think it's also worth tracking.

[FedeGueli]

There is a subbranch with S:G184S. I think it's also worth tracking.

query: G22112A,C28706T, C6312A
Samples:11

Please @Fearuncle add this to the title ad the man proposal

[Over-There-Is]

EPI_ISL_19280116 imported from Peru

[Fearuncle]

9 with ORF1a:S944L + S:E1202G

[Fearuncle]

Passed 200 seq.

[FedeGueli]

9 with ORF1a:S944L + S:E1202G (C3096T, A25167G, C28706T)

This is a canadian cluster >> scoring high for growth advantage but worth keeping it tracked if it starts emerging elsewhere.
@ryhisner any idea if S:E1202G could mean something? it is the same residue of the double nuc (silent 1201 + 1202K) we saw multiple times

[ryhisner]

Fede, you're thinking of S:Q1201K, which often has a silent mutation in S:L1200. But Q1201K also shows up pretty frequently without that second nuc mutation (which creates a suboptimal TRS motif), so I think it must have a function apart from its TRS implications. I don't know what it would be though. I don't think this region is an antibody target, but it's hard to be sure.

[FedeGueli]

Fede, you're thinking of S:Q1201K, which often has a silent mutation in S:L1200. But Q1201K also shows up pretty frequently without that second nuc mutation (which creates a suboptimal TRS motif), so I think it must have a function apart from its TRS implications. I don't know what it would be though. I don't think this region is an antibody target, but it's hard to be sure.

Yeah sorry i miss recalled it as 1202 it is obviously 1201! and 1200 as silent. thank you very much!

[FedeGueli]

26 for the Orf1a:944L branch

[FedeGueli]

@corneliusroemer 3 weeks without designation now, please designate some variants in https://github.com/cov-lineages/pango-designation/issues

How many times would you post this?

[FedeGueli]

It seems dying off to me or at least low priority now that many fast sublineages are popping up

[xz-keg]

designated KP.2.3.14

[FedeGueli]

designated KP.2.3.14
via
0c66521