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It's useful to be able to answer questions about the reference sequences, so we should at least have a list of the accession numbers. It might also be helpful to have a script that can fetch them all.
As a start, here's a list of the HCV references from the FDA guidance (PDF):
HCV Genotype
Reference Strain
GenBank Accession ID
Genotype 1a
H77
NC_004102
Genotype 1b
Con1
AJ238799
Genotype 2
JFH-1
AB047639
Genotype 3
S52
GU814263
Genotype 4
ED43
GU814265
Genotype 5
SA13
AF064490
Genotype 6
EUHK2
Y12083
Compare HIV seeds to HIV compendium.
Check if we used all references from the HIV compendium.
Compare HIV coordinate references to HXB2.
Explain changes from HXB2.
Compare HCV references.
Compare HLA references.
Compare V3LOOP reference used in G2P .
Remove ERCC references.
Use HIV Consensus B for resistance wild types.
Configuration changes:
Upload projects to QAI's pipeline configuration. There are changes in HIV1B-vpr and several HCV seed and coordinate references, plus we removed the ERCC project.
The text was updated successfully, but these errors were encountered:
There were gaps between some of the gene regions, and a few of the seeds had small differences. The HCV-6n seed had a more significant change that will need to be validated.
It's useful to be able to answer questions about the reference sequences, so we should at least have a list of the accession numbers. It might also be helpful to have a script that can fetch them all.
As a start, here's a list of the HCV references from the FDA guidance (PDF):
Configuration changes:
The text was updated successfully, but these errors were encountered: