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Updateed QC and reproducibility lessons #27

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32 changes: 23 additions & 9 deletions _episodes/05-Image_QC.md
Original file line number Diff line number Diff line change
Expand Up @@ -18,31 +18,45 @@ keypoints:
### Acquistion
#### Due to MR physics (e.g. Field of view (FOV), ghosting, aliasing)
Incorrect parameters can truncate and/or duplicate brain anatomy.
![MR_physics_QC](../fig/episode_5/MR_physics_QC.png)


<img src="../fig/episode_5/MR_physics_QC.png" alt="Drawing" align="middle" width="500px"/>

#### Due to participant (e.g. Motion artifacts)
- Participant specific issues such as motion artifcats in Parkinson's patients can manifest in the scan (e.g. ringing effect showing ripples or curved lines).
![Motion_QC](../fig/episode_5/Motion_QC.png)

<img src="../fig/episode_5/Motion_QC.png" alt="Drawing" align="middle" width="500px"/>

### Quantification
Exisiting image processing pipelines (e.g. FreeSurfer, CIVET) will have a few QC tools and examples that can help with failure detection and quality control of volumetric segmentations and surface parcellations.

![Segment_and_surface_QC](../fig/episode_5/Segment_and_surface_QC.png)
<img src="../fig/episode_5/Segment_and_surface_QC.png" alt="Drawing" align="middle" width="500px"/>

Usage of new method will require your own QC protocols. Especially for highly specific segmentation methods require visual inspection from a neuroanatomy expert. Even for the qualitiative visual inspection, it is important create a QC protocol and share it with the results.

![HC_and_CB_MAGeT](../fig/episode_5/HC_and_CB_MAGeT.png)

_Note: see [Hippocampal](http://dx.doi.org/10.1016/j.neuroimage.2014.04.054) and [cerebellar](https://www.sciencedirect.com/science/article/pii/S1053811914001840?via%3Dihub) for segmentation method details._

## Automatic QC tools
- Using reports from exisiting pipelines: https://fmriprep.org/en/stable/_static/sample_report.html
![sMRIPrep_QC_report](../fig/episode_5/sMRIPrep_QC_report.png)

- Using QC tools
- [VisualQC](https://github.com/raamana/visualqc) : assistive tool to improve the quality control workflow of neuroimaging data (Author: Pradeep Reddy Raamana).
### Using reports from exisiting pipelines: https://fmriprep.org/en/stable/_static/sample_report.html

<img src="../fig/episode_5/sMRIPrep_QC_report.png" alt="Drawing" align="middle" width="700px"/>


### Using QC tools

#### [MRIQC](https://github.com/poldracklab/mriqc): extracts no-reference IQMs (image quality metrics) from structural (T1w and T2w) and functional MRI (magnetic resonance imaging) data. _(Developed by the Poldrack Lab at Stanford University for use at the Center for Reproducible Neuroscience (CRN), as well as for open-source software distribution.)_

| Individual report | Group report |
| :-------------: | :-----------: |
| <img src="../fig/episode_5/mriqc_individual_report.png" alt="Drawing" align="middle" width="700px"/> | <img src="../fig/episode_5/mriqc_group_report.png" alt="Drawing" align="middle" width="450px"/> |


#### [VisualQC](https://github.com/raamana/visualqc): assistive tool to improve the quality control workflow of neuroimaging data (Author: Pradeep Reddy Raamana).

| T1w acquisition | Alignment | Cortical Parcellation |
| :-------------: | :-----------: |:-----------: |
| ![t1_mri_visual_QC](../fig/episode_5/t1_mri_visual_QC.png) | ![alignment_mismatched_colormix_visualQC](../fig/episode_5/alignment_mismatched_colormix_visualQC.png) | ![cortical_zoomed_in](../fig/episode_5/cortical_zoomed_in.png)|

{% include links.md %}
{% include links.md %}
10 changes: 9 additions & 1 deletion _episodes/07-Reproducibility.md
Original file line number Diff line number Diff line change
Expand Up @@ -19,7 +19,7 @@ keypoints:

- Software (algorithms and their versions)
- Image clean-up
- Image preproc
- Image normalization
- Image quantification

- Quality control
Expand All @@ -43,5 +43,13 @@ _Note: See [this]([https://academic.oup.com/cercor/article/30/9/5014/5831485]) f

![software_compare](../fig/episode_8/CT_compare_software.png)


## Possible choices for FreeSurfer parcellations
- Different parcellation different results?
- Inference pertaining to neuroantomical differences and/or prediction models based on individual neuroanatomical feature sets can be sensitive to parcellation choice.

![software_compare](../fig/episode_8/FreeSurfer_parcels.jpg)
_Note: Image adopted from [Madan 2021](https://link.springer.com/article/10.1007/s12021-021-09519-6)

{% include links.md %}

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