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ED Web API for Protein Position Mutation Count
#Design : Web API for Protein Position Mutation Count Date accepted: 2016-11-23
Abstract: A Web API endpoint at {appname}/api-legacy/mutation-count-by-protein-positions would return a list of results in the JSON form [{hugoGeneSymbol:TP53,position:83,count:11},...].The position represents the standard amino acid residue from the start of the canonical gene isoform, and the count is the total number of mutation events detected at this position in the referenced protein across all genetic profiles of alteration type EXTENDED_MUTATION. The input parameter value is a list of mappings from hugo gene symbol string to a list of integers. This mapping defines all requested positions (per gene) at which a count is desired in the return value.
Example Use:
Input: {“TP53”:[30,43,112],”AKT1”:[3,12]}
Output: [{“hugoGeneSymbol”:”TP53”,”position”:30,”count”:11},
{“hugoGeneSymbol”:”TP53”,”position”:43,”count”:82},
{“hugoGeneSymbol”:”TP53”,”position”:112,”count”:6},
{“hugoGeneSymbol”:”AKT1”,”position”:3,”count”:0},
{“hugoGeneSymbol”:”AKT1”,”position”:12,”count”:7}]
cBioPortal, 2017