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Update ascat threshold
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jamesqo authored Jul 27, 2024
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6 changes: 3 additions & 3 deletions docs/user-guide/faq.md
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Expand Up @@ -244,12 +244,12 @@ By contrast, the high-level thresholds are calculated on a sample-by-sample basi
| TCN = 0 | -2 | Deep loss |
| TCN = 1 | -1 | Single-copy loss |
| TCN = 2 | 0 | Diploid |
| 2 < TCN < 6 | 1 | Low-level gain |
| 6 ≤ TCN | 2 | Amplification |
| 2 < TCN < 7 | 1 | Low-level gain |
| 7 ≤ TCN | 2 | Amplification |

where TCN is the total copy number from ASCAT.

The final conversion threshold (6 ≤ TCN) is somewhat flexible and can vary between different studies depending on the data used. We chose 6 and applied it to all GDC studies after seeing that it resulted in the most consistency between GDC TCGA and PanCancer Atlas.
The final conversion threshold (7 ≤ TCN) is somewhat flexible and can vary between different studies depending on the data used. We chose 7 and applied it to all GDC studies after seeing that it resulted in the most consistency between GDC TCGA and PanCancer Atlas.

### RNA
#### Does the portal store raw or probe-level data?
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