VarAlign: Genetic Variation Analysis in Pfams - Communications Biology Release

VarAlign is a Python module designed for aggregating human genetic variation and structural features across multiple sequence alignment columns. VarAlign facilitates in-depth analysis of genetic variations in relation to protein structure, offering insights into evolutionary conservation and population constraints.

This release archives the VarAlign version used to generate data for our publication, "A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites.", accepted in principle by Communications Biology.

Please Note: This is an archival release intended for replication and citation purposes related to the publication. For those wishing to utilise VarAlign for new projects, we recommend exploring more recent versions of the software for the latest features and enhancements.

Citation:

For detailed methodology and findings, refer to our paper: Stuart A. MacGowan, Fábio Madeira, Thiago Britto-Borges and Geoffrey J. Barton, "A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites." Pre-print available at https://doi.org/10.21203/rs.3.rs-3160340/v1.

License:

Released under the MIT license by Stuart A. MacGowan and contributors at the University of Dundee.

Feedback and contributions are welcomed to refine and enhance this project. We invite bug reports, feature requests, and code contributions to improve VarAlign.