GitHub - amatov/SegmentationBiomarkerCTC: Our image analysis software performs segmentation of the cellular areas with cell surface expression of the prostate-specific membrane antigen to improve the precision of therapy and its customization

Name		Name	Last commit message	Last commit date
Latest commit History 108 Commits
Coverslip		Coverslip
HoughTransform		HoughTransform
SVM		SVM
Segmentation3D		Segmentation3D
WaveletSeedingWatershedActiveContour		WaveletSeedingWatershedActiveContour
spotDetection		spotDetection
GUI.jpg		GUI.jpg
MatovGlioblastomaCellAnalysis_2017.MOV		MatovGlioblastomaCellAnalysis_2017.MOV
MatovMicrotubuleBundling2013.pdf		MatovMicrotubuleBundling2013.pdf
README.md		README.md
awt.cpp		awt.cpp
awt.mexw64		awt.mexw64
datasets_find_9283.ini		datasets_find_9283.ini
datasets_optimal.ini		datasets_optimal.ini
find_ctc.exe		find_ctc.exe
genOptimalCTC2.m		genOptimalCTC2.m
optimal_ctc.exe		optimal_ctc.exe
readme.txt		readme.txt
run_optimal_detection_9283.bat		run_optimal_detection_9283.bat

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Algorithm for the segmentation of prostate-specific membrane antigen labeling in ciruculating tumor cells of metastatic patients I designed and partially implemented (see also folder Wavelet Seeding Watershed Active Contour)

The patient blood samples analyzed were from clinical studies with IRB protocols 0804009740 and 0707009283 at Cornell Medicine and NCT01718353 phase II clinical trial sponsored by Sanofi for early switch from Docetaxel to Cabazitaxel during the treatment of metastatic castrate-resistant prostate cancer

See examples of image processing of whole slides in folder Coverslip

Watch my CTC presentation, the second part of this seminar, at the University of Central Florida in 2013: https://youtube.com/watch?v=kTYyltX9RFg

Presentations and funding applications on this project are available here: http://dx.doi.org/10.13140/RG.2.2.15239.37286 (8 PDF files)

Applications to drug discovery in glioblastoma of these algorithms, I have presented here (see also the real-time analysis video of cells treated with ara-C above): http://dx.doi.org/10.13140/RG.2.2.11459.58409/2 (2 PDF files)