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This repository contains all the PAIN-3 project code

Name                           | Type   | Description
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bolt_lmm                       | folder | This folder contains scripts for mixed model association testing using BOLT-LMM algorithm.
cojo                           | folder | This folder contains scripts for congenital & joint (COJO) analysis.
depict                         | folder | This folder contains scripts for Data-driven Expression Prioritized Integration for Complex Traits (DEPICT) analysis.
fathmm                         | folder | This folder contains scripts for FATHMM (Predictor of the Functional Consequences of Coding and Non-Coding Variants).
filtering_and_scaling          | folder | This folder contains scripts for filtering and scaling of the data.
gene_cor_and_heritability      | folder | This folder contains scripts for calculation of genetic correlations and heretability for different human traits.
GIP_calculation                | folder | This folder contains scripts for calculation of GWAS summary statistics of Genetically Independent Phenotypes (GIPs).
plots                          | folder | This folder contains scripts for drawing plots.
run_meta-analysis              | folder | This folder contains scripts for running meta-analysis using METAL software.
smr_heidi                      | folder | This folder contains scripts for summary data-based Mendelian randomization (SMR) and heterogeneity in dependent instruments (HEIDI) test.
tables_creation                | folder | This folder contains scripts for creation of tables from Supplementary note.
upload_to_GWAS-Map             | folder | This folder contains mapping and descritor files, scripts for unification of GWAS summary statistics and scripts for uploading them to the GWAS-Map platform.
estimation_of_GIP_coefficients | folder | This folder contains scripts for estimatiob of GIP alfa coefficients. 
scripts_for_revision_R1        | folder | This folder contains scripts that was produced for the revision R1 of original paper. 
data_for_plots                 | folder | This folder contains source data for graphs and figures from paper. 

Note: here and below abbreviation "GPC" (Genetic Principal Component) is a synonym for "GIP" (Genetically Independent Phenotype).

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