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glossary fixes: improved descriptions
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cbielow committed Dec 3, 2024
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:sorted:

C18
octadecyl
Octadecyl (C18) is an alkyl radical C(18)H(37) derived from an octadecane by removal of one hydrogen atom.

CID
collision-induced dissociation
Collision-induced dissociation is an MS technique to induce fragmentation of selected ions in the gas phase, which are subjected to a subsequent measurement (see :term:`MS2`).
Collision-induced dissociation is an MS technique to induce fragmentation of selected ions in the gas phase,
which are subjected to a subsequent measurement (see :term:`MS2`).

consensus features
consensus feature
Features from replicate experiments with similar retention times and m/z values are linked and considered a consensus feature.
A consensus feature contains information on the common retention time and m/z values as well as intensities for each sample. OpenMS represents a consensus feature using the class `ConsensusFeature <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/classOpenMS_1_1ConsensusFeature.html>`_.
A consensus feature contains information on the common retention time and m/z values as well as intensities for each sample.
OpenMS represents a consensus feature using the class `ConsensusFeature
<https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/classOpenMS_1_1ConsensusFeature.html>`_.

consensus maps
consensus map
A consensus map is a collection of :term:`consensus features` identified from mass spectra across replicate experiments, usually by combining multiple :term:`feature maps`.
One consensus map usually contains many consensus features. OpenMS represents a consensus map using the class `ConsensusMap <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/classOpenMS_1_1ConsensusMap.html>`_.
A consensus map is a collection of :term:`consensus features` identified from mass spectra across replicate experiments,
usually by combining multiple :term:`feature maps`.
One consensus map usually contains many consensus features. OpenMS represents a consensus map using
the class `ConsensusMap <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/classOpenMS_1_1ConsensusMap.html>`_.

de novo peptide sequencing
A peptides amino acid sequence is inferred directly from the precursor peptide mass and tandem
A peptide's amino acid sequence is inferred directly from the precursor peptide mass and tandem
mass spectrum (:term:`MS2` or :term:`MS3`) fragment ions, without comparison to a reference proteome.

electrospray ionization
ESI
Electrospray ionization (ESI) is a technique used in MS to produce ions.

FASTA
A text-based format for representing nucleotide or amino acid sequences.
A text-based file format for representing nucleotide or amino acid sequences.

feature
features
A feature, in the OpenMS terminology, subsumes all m/z signals originating from a single compound at a certain charge state. This includes the isotope pattern and usually spans multiple spectra in retention time (the elution profile).
A feature, in the OpenMS terminology, subsumes all m/z signals originating from a single compound at a
certain charge state. This includes the isotope pattern and usually spans multiple spectra in retention time (the elution profile).

feature maps
feature map
A feature map is a collection of :term:`feature`\ s identified from a single experiment.
One feature map usually contains many features. OpenMS represents a feature map using the class `FeatureMap <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/classOpenMS_1_1FeatureMap.html>`_.
One feature map usually contains many features. OpenMS represents a feature map using the class
`FeatureMap <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/classOpenMS_1_1FeatureMap.html>`_.

high performance liquid chromatography
HPLC
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interacts with the stationary phase.

iTRAQ
Isobaric tags for relative and absolute quantitation (iTRAQ) is a MS based multiplexing technique designed to identify and quantify proteins from different samples in one single measurement.
Isobaric tags for relative and absolute quantitation (iTRAQ) is a MS based multiplexing technique designed to
identify and quantify proteins from different samples in one single measurement.

KNIME
An advanced workflow editor which OpenMS provides a plugin for.
Expand All @@ -71,17 +78,21 @@ A glossary of common terms used throughout OpenMS documentation.

LuciphorAdapter
Adapter for the LuciPHOr2: a site localisation tool of generic post-translational modifications from tandem mass
spectrometry data. More information is available in the `OpenMS API reference documentation <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPP_LuciphorAdapter.html>`__.
spectrometry data. More information is available in the `OpenMS API reference documentation
<https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPP_LuciphorAdapter.html>`__.

Mass Spectrometry
MS
An analytical technique to measure the mass over charge (m/z) ratio of ions along with their abundance. This gives rise to a mass spectrum (with m/z on the x-axis and abundance on the y-axis).
An analytical technique to measure the mass over charge (m/z) ratio of ions along with their abundance.
This gives rise to a mass spectrum (with m/z on the x-axis and abundance on the y-axis).

mass spectrum
A visual or numerical representation of a measurement from an MS instrument. A spectrum contains (usually many) pairs of mass-over-charge(m/z)+intensity values.
A visual or numerical representation of a measurement from an MS instrument.
A spectrum contains (usually many) pairs of mass-over-charge(m/z)+intensity values.

MascotAdapter
Used to identify peptides in :term:`MS2` spectra. Read more about MascotAdapter in the `OpenMS API reference documentation <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPP_MascotAdapter.html>`__.
Used to identify peptides in :term:`MS2` spectra. Read more about this adapter in the `OpenMS API reference documentation
<https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPP_MascotAdapter.html>`__.

MSGFPlusAdapter
Adapter for the MS-GF+ protein identification (database search) engine. More information is available in the
Expand All @@ -93,8 +104,8 @@ A glossary of common terms used throughout OpenMS documentation.

MS2
MS/MS
tandem mass spectrometry
Tandem MS is a technique where two or more mass analyzers are coupled together using an additional, usually destructive, reaction step to generate fragment ions which increases their abilities to analyse chemical samples.
Tandem MS is a technique where two or more mass analyzers are coupled together using an additional, usually destructive,
reaction step to generate fragment ions which increases their abilities to analyse chemical samples.

MS3
Multi-stage MS.
Expand Down Expand Up @@ -142,7 +153,8 @@ A glossary of common terms used throughout OpenMS documentation.
It provides a framework for unified MS data file access and performs standard chemistry and LCMS dataset computations.

quadrupole
A mass filter allowing one mass channel at a time to reach the detector as the mass range is scanned. A low resolution MS analyzer.
A low resolution MS analyzer.
A mass filter allowing one mass channel at a time to reach the detector as the mass range is scanned.

SILAC
stable isotope labeling with amino acids in cell culture
Expand All @@ -152,29 +164,35 @@ A glossary of common terms used throughout OpenMS documentation.
Selected reaction monitoring (SRM) is a MS technique for targeted small molecule analysis.

SWATH
Sequential acquisition of all theoretical fragment ion spectra (SWATH) uses partially overlapping MS2 scans with wide isolation windows to capture all fragment ions in a data independent analysis (DIA).
Sequential acquisition of all theoretical fragment ion spectra (SWATH) uses partially overlapping MS2
scans with wide isolation windows to capture all fragment ions in a data independent analysis (DIA).

tandem mass spectrometry
See :term:`MS2`.

time-of-flight
TOF
Time-of-flight (TOF) is the time taken by an object, particle or wave (be it acoustic, electromagnetic, etc.) to travel a distance through a medium.
Time-of-flight (TOF) is the time taken by an object, particle or wave (be it acoustic, electromagnetic, etc.)
to travel a distance through a medium.
TOF analyzers can obtain good, but not ultra-high resolution, such as an :term:`orbitrap`.

TMT
Tandem Mass Tag (TMT) is a MS based multiplexing technique designed to identify and quantify proteins from different samples in one single measurement.
Tandem Mass Tag (TMT) is a MS based multiplexing technique designed to identify and
quantify proteins from different samples in one single measurement.

TOPP
'TOPP - The OpenMS PiPeline' is a pipeline for the analysis of HPLC-MS data. It consists of several small applications that can be chained to create analysis pipelines tailored for a specific problem. See :term:`TOPP tools`.
'TOPP - The OpenMS PiPeline' is a pipeline for the analysis of HPLC-MS data. It consists of several small
applications that can be chained to create analysis pipelines tailored for a specific problem. See :term:`TOPP tools`.

TOPPAS
An assistant for GUI-driven :term:`TOPP` workflow design, build into OpenMS. See `TOPPAS tutorial <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPPAS_tutorial.html>` for details.
An assistant for GUI-driven :term:`TOPP` workflow design, build into OpenMS.
See `TOPPAS tutorial <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPPAS_tutorial.html>` for details.

TOPP tools
OpenMS provides a number of applications (executable files) that are chainable in a pipeline/script and each process MS data.
These tools are subdivided into different categories, such as 'File Handling' or 'Peptide Identification'.
All :term:`TOPP` tools are described in the `OpenMS API reference documentation <https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPP_documentation.html>`__.
All :term:`TOPP` tools are described in the `OpenMS API reference documentation
<https://abibuilder.cs.uni-tuebingen.de/archive/openms/Documentation/nightly/html/TOPP_documentation.html>`__.

TOPPView
TOPPView is a viewer for
TOPPView is a viewer for MS and HPLC-MS data and shipped with every OpenMS release.

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