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Simulations of modulation of HCN channels in L5PCs (Mäki-Marttunen and Mäki-Marttunen accepted)
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This entry contains the scripts for simulating the model of our article "Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells".<br>
<br>
Two folders are included in this ModelDB entry:<br>
<code>modulhcn_almog</code><br>
<code>modulhcn_hay</code><br>
<br>
Before running any simulations, run "nrnivmodl" in both folders to compile the .mod mechanisms.<br>
<br>
To run the simulations for Fig. 1 and draw the results, run the following commands:<br>
<font color=green><pre>
cd modulhcn_almog
sh runfig1.sh
cd ../modulhcn_hay
sh runfig1.sh
cd ..
python3 drawfig1.py</pre>
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In the same way, to draw Fig. 2-6, do the same procedure, replacing '1' by numbers 2-6.
Note that Fig. 3 and Fig. 5 re-use data from Fig. 2, so run runfig2.sh in addition to runfig3.sh and runfig5.sh to be able to draw the figures (and similarly, Fig. 6 re-uses data from Fig. 4).<br>
<br>
Approximate simulation times:
<pre>
modulhcn_almog/runfig1.sh: 1-2 days
modulhcn_almog/runfig2.sh: 2-3 hours
modulhcn_almog/runfig3.sh: 2 hours
modulhcn_almog/runfig4.sh: 4-7 days
modulhcn_hay/runfig1.sh: 3-6 hours
modulhcn_hay/runfig2.sh: 20 min
modulhcn_hay/runfig3.sh: 30 min
modulhcn_hay/runfig4.sh: 1-2 days
modulhcn_hay/runfig5.sh: 5-10 days
modulhcn_hay/runfig6.sh: 2-3 days
</pre>
<p><h3>Changelog</h3>
2022-12: MOD-C-2-CPP: Compatibility fixed for NEURON 9.0, 8.2 and 8.1
Fix for 9.0.0: curr used as both variable and function in file epsp.mod
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Simulations of modulation of HCN channels in L5PCs (Mäki-Marttunen and Mäki-Marttunen accepted)