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Latini2023_JMD_updated.sbml
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Latini2023_JMD_updated.sbml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1" xmlns:qual="http://www.sbml.org/sbml/level3/version1/qual/version1" qual:required="true">
<model id="JMD">
<listOfCompartments>
<compartment id="default" constant="true"/>
</listOfCompartments>
<qual:listOfQualitativeSpecies>
<qual:qualitativeSpecies qual:id ="FLT3" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="AKT1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="MAPK1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="GSK3B" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="KRAS" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="MAPK14" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="MAP2K1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="MTOR" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="PDPK1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="PTPN11" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="RPS6KA1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="RPS6KB1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="TNF" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="IGF1R" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="IRS1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="GSK3A" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="INSR" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="SHC1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="GRB2" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="KIT" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="PTPN1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="CBL" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="PTEN" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="TSC2" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="MAPK8" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="PIK3CA" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="STAT3" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="RPS6" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="CREB1" qual:compartment="main" qual:constant="false"/>
<qual:qualitativeSpecies qual:id ="STAT5A" qual:compartment="main" qual:constant="false"/>
</qual:listOfQualitativeSpecies>
<qual:listOfTransitions>
<qual:transition qual:id="t1">
<qual:listOfInputs>
<qual:input qual:id="theta_t1_TNF" qual:qualitativeSpecies="TNF" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t1_MAPK8" qual:qualitativeSpecies="MAPK8" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t1_MAP2K1" qual:qualitativeSpecies="MAP2K1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t1_STAT3" qual:qualitativeSpecies="STAT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t1_MAP2K1" qual:qualitativeSpecies="MAP2K1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t1_IGF1R" qual:qualitativeSpecies="IGF1R" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="FLT3" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> TNF </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> MAPK8 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> MAP2K1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> STAT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> MAP2K1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> IGF1R </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t2">
<qual:listOfInputs>
<qual:input qual:id="theta_t2_MTOR" qual:qualitativeSpecies="MTOR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_GSK3A" qual:qualitativeSpecies="GSK3A" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_MTOR" qual:qualitativeSpecies="MTOR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_PTPN1" qual:qualitativeSpecies="PTPN1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_TNF" qual:qualitativeSpecies="TNF" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_PTPN1" qual:qualitativeSpecies="PTPN1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_TNF" qual:qualitativeSpecies="TNF" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_PTEN" qual:qualitativeSpecies="PTEN" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_IGF1R" qual:qualitativeSpecies="IGF1R" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t2_PTEN" qual:qualitativeSpecies="PTEN" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="AKT1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci> MTOR </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> GSK3A </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> MTOR </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PTPN1 </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> TNF </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PTPN1 </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> TNF </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PTEN </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> IGF1R </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PTEN </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t3">
<qual:listOfInputs>
<qual:input qual:id="theta_t3_KIT" qual:qualitativeSpecies="KIT" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_PTPN11" qual:qualitativeSpecies="PTPN11" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_MAPK8" qual:qualitativeSpecies="MAPK8" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_MAP2K1" qual:qualitativeSpecies="MAP2K1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_KIT" qual:qualitativeSpecies="KIT" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_SHC1" qual:qualitativeSpecies="SHC1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_KIT" qual:qualitativeSpecies="KIT" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_FLT3" qual:qualitativeSpecies="FLT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_SHC1" qual:qualitativeSpecies="SHC1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_PTPN11" qual:qualitativeSpecies="PTPN11" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t3_KIT" qual:qualitativeSpecies="KIT" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="MAPK1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> KIT </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PTPN11 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> MAPK8 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> MAP2K1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> KIT </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> SHC1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> KIT </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> FLT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> SHC1 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> PTPN11 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> KIT </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t4">
<qual:listOfInputs>
<qual:input qual:id="theta_t4_MAPK1" qual:qualitativeSpecies="MAPK1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t4_MAP2K1" qual:qualitativeSpecies="MAP2K1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t4_MAPK1" qual:qualitativeSpecies="MAPK1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t4_RPS6KA1" qual:qualitativeSpecies="RPS6KA1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="GSK3B" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci> MAPK1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> MAP2K1 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> MAPK1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> RPS6KA1 </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t5">
<qual:listOfInputs>
<qual:input qual:id="theta_t5_PTPN11" qual:qualitativeSpecies="PTPN11" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="KRAS" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<apply>
<eq/>
<ci> PTPN11 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t6">
<qual:listOfInputs>
<qual:input qual:id="theta_t6_TNF" qual:qualitativeSpecies="TNF" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t6_PIK3CA" qual:qualitativeSpecies="PIK3CA" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t6_RPS6KB1" qual:qualitativeSpecies="RPS6KB1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t6_FLT3" qual:qualitativeSpecies="FLT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t6_TNF" qual:qualitativeSpecies="TNF" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="MAPK14" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> TNF </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PIK3CA </ci>
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</apply>
<apply>
<eq/>
<ci> RPS6KB1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> FLT3 </ci>
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</apply>
<apply>
<eq/>
<ci> TNF </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t7">
<qual:listOfInputs>
<qual:input qual:id="theta_t7_PIK3CA" qual:qualitativeSpecies="PIK3CA" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t7_MTOR" qual:qualitativeSpecies="MTOR" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t7_PIK3CA" qual:qualitativeSpecies="PIK3CA" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t7_RPS6KB1" qual:qualitativeSpecies="RPS6KB1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="MAP2K1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> PIK3CA </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> MTOR </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> PIK3CA </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> RPS6KB1 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t8">
<qual:listOfInputs>
<qual:input qual:id="theta_t8_STAT3" qual:qualitativeSpecies="STAT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t8_MAPK8" qual:qualitativeSpecies="MAPK8" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="MTOR" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> STAT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> MAPK8 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t9">
<qual:listOfInputs>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="PDPK1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t10">
<qual:listOfInputs>
<qual:input qual:id="theta_t10_KIT" qual:qualitativeSpecies="KIT" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="PTPN11" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<apply>
<eq/>
<ci> KIT </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t11">
<qual:listOfInputs>
<qual:input qual:id="theta_t11_PDPK1" qual:qualitativeSpecies="PDPK1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="RPS6KA1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<apply>
<eq/>
<ci> PDPK1 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t12">
<qual:listOfInputs>
<qual:input qual:id="theta_t12_STAT3" qual:qualitativeSpecies="STAT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="RPS6KB1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<apply>
<eq/>
<ci> STAT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t13">
<qual:listOfInputs>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="TNF" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t14">
<qual:listOfInputs>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="IGF1R" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t15">
<qual:listOfInputs>
<qual:input qual:id="theta_t15_INSR" qual:qualitativeSpecies="INSR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t15_IGF1R" qual:qualitativeSpecies="IGF1R" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t15_INSR" qual:qualitativeSpecies="INSR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t15_INSR" qual:qualitativeSpecies="INSR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t15_PTPN1" qual:qualitativeSpecies="PTPN1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="IRS1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> INSR </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> IGF1R </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> INSR </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> INSR </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PTPN1 </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t16">
<qual:listOfInputs>
<qual:input qual:id="theta_t16_FLT3" qual:qualitativeSpecies="FLT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t16_CREB1" qual:qualitativeSpecies="CREB1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t16_RPS6" qual:qualitativeSpecies="RPS6" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t16_MAPK8" qual:qualitativeSpecies="MAPK8" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t16_PIK3CA" qual:qualitativeSpecies="PIK3CA" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="GSK3A" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> FLT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> CREB1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> RPS6 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> MAPK8 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> PIK3CA </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t17">
<qual:listOfInputs>
<qual:input qual:id="theta_t17_PTPN1" qual:qualitativeSpecies="PTPN1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t17_GSK3A" qual:qualitativeSpecies="GSK3A" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t17_GSK3A" qual:qualitativeSpecies="GSK3A" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t17_CBL" qual:qualitativeSpecies="CBL" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="INSR" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> PTPN1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> GSK3A </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> GSK3A </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> CBL </ci>
<cn type='integer'> 0 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t18">
<qual:listOfInputs>
<qual:input qual:id="theta_t18_IGF1R" qual:qualitativeSpecies="IGF1R" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t18_INSR" qual:qualitativeSpecies="INSR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="SHC1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<and/>
<apply>
<eq/>
<ci> IGF1R </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> INSR </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t19">
<qual:listOfInputs>
<qual:input qual:id="theta_t19_IRS1" qual:qualitativeSpecies="IRS1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t19_IRS1" qual:qualitativeSpecies="IRS1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t19_SHC1" qual:qualitativeSpecies="SHC1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t19_IRS1" qual:qualitativeSpecies="IRS1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t19_KIT" qual:qualitativeSpecies="KIT" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t19_FLT3" qual:qualitativeSpecies="FLT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t19_SHC1" qual:qualitativeSpecies="SHC1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="GRB2" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<or/>
<apply>
<eq/>
<ci> IRS1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> IRS1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> SHC1 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> IRS1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> KIT </ci>
<cn type='integer'> 1 </cn>
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</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> FLT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> SHC1 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t20">
<qual:listOfInputs>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="KIT" qual:transitionEffect="assignmentLevel"/>
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<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t21">
<qual:listOfInputs>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="PTPN1" qual:transitionEffect="assignmentLevel"/>
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<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t22">
<qual:listOfInputs>
<qual:input qual:id="theta_t22_INSR" qual:qualitativeSpecies="INSR" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t22_GRB2" qual:qualitativeSpecies="GRB2" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="CBL" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<or/>
<apply>
<eq/>
<ci> INSR </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> GRB2 </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t23">
<qual:listOfInputs>
<qual:input qual:id="theta_t23_GSK3B" qual:qualitativeSpecies="GSK3B" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t23_CREB1" qual:qualitativeSpecies="CREB1" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t23_TSC2" qual:qualitativeSpecies="TSC2" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t23_RPS6KB1" qual:qualitativeSpecies="RPS6KB1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t23_TSC2" qual:qualitativeSpecies="TSC2" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t23_RPS6" qual:qualitativeSpecies="RPS6" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="PTEN" qual:transitionEffect="assignmentLevel"/>
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<qual:listOfFunctionTerms>
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<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<or/>
<apply>
<eq/>
<ci> GSK3B </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> CREB1 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> TSC2 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> RPS6KB1 </ci>
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</apply>
<apply>
<eq/>
<ci> TSC2 </ci>
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</apply>
<apply>
<eq/>
<ci> RPS6 </ci>
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</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t24">
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<qual:input qual:id="theta_t24_MAPK1" qual:qualitativeSpecies="MAPK1" qual:transitionEffect="none" qual:sign="negative" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t24_GSK3B" qual:qualitativeSpecies="GSK3B" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
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<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="TSC2" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> MAPK1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> MAPK1 </ci>
<cn type='integer'> 0 </cn>
</apply>
<apply>
<eq/>
<ci> GSK3B </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="t25">
<qual:listOfInputs>
<qual:input qual:id="theta_t25_FLT3" qual:qualitativeSpecies="FLT3" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
<qual:input qual:id="theta_t25_TNF" qual:qualitativeSpecies="TNF" qual:transitionEffect="none" qual:sign="positive" qual:thresholdLevel="1"/>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="MAPK8" qual:transitionEffect="assignmentLevel"/>
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<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0"/>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<and/>
<apply>
<eq/>
<ci> FLT3 </ci>
<cn type='integer'> 1 </cn>
</apply>
<apply>
<eq/>
<ci> TNF </ci>
<cn type='integer'> 1 </cn>
</apply>
</apply>