The AstroBio Explorer is a small web-application designed to analyze a curated list of differential gene expression experiments for organisms treated with both spaceflight and simulated microgravity. Using various R packages and the Shiny web development framework, users can both examine results using a variety of interactive plots and download them in a excel spreadsheet format. Using the g:Profiler API, users can also perform automated gene set enrichment analysis to find differentially regulated functional groups from a large subset of the most popular gene annotation databases (Raudvere et al., 2019). The results are displayed in several interactive plots and tables and are available to download.
All data is derived from iGEM Concordia's 2020 project AstroBio.
The most recent version is hosted at https://igem-concordia.shinyapps.io/astrobio_explorer/ .
Author: Benjamin Clark
Raudvere, U., Kolberg, L., Kuzmin, I., Arak, T., Adler, P., Peterson, H., & Vilo, J. (2019). g:Profiler: A web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Research, 47(W1), W191–W198. https://doi.org/10.1093/nar/gkz369