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After performing normalize(data.obj, method = "CLR") on the readcount data, I found that some taxa with small readcount values were transformed into negative numbers (which is normal), but the zero values remain. It is a completely incorrect data.
The function should automatically handle zero values (e.g., by adding 1 to all zeros), or provide some method parameters for handling zero values.
The text was updated successfully, but these errors were encountered:
After performing
normalize(data.obj, method = "CLR")
on the readcount data, I found that some taxa with small readcount values were transformed into negative numbers (which is normal), but the zero values remain. It is a completely incorrect data.The function should automatically handle zero values (e.g., by adding 1 to all zeros), or provide some method parameters for handling zero values.
The text was updated successfully, but these errors were encountered: