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CLR Normalization does not automatically handle zero values #115

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qqwxp opened this issue Apr 18, 2024 · 0 comments
Open

CLR Normalization does not automatically handle zero values #115

qqwxp opened this issue Apr 18, 2024 · 0 comments

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@qqwxp
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qqwxp commented Apr 18, 2024

After performing normalize(data.obj, method = "CLR") on the readcount data, I found that some taxa with small readcount values were transformed into negative numbers (which is normal), but the zero values remain. It is a completely incorrect data.

The function should automatically handle zero values (e.g., by adding 1 to all zeros), or provide some method parameters for handling zero values.

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