diff --git a/Cargo.lock b/Cargo.lock
index bf197e9d49..cf6c7949af 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -170,9 +170,9 @@ dependencies = [
 
 [[package]]
 name = "bstr"
-version = "1.10.0"
+version = "1.11.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "40723b8fb387abc38f4f4a37c09073622e41dd12327033091ef8950659e6dc0c"
+checksum = "1a68f1f47cdf0ec8ee4b941b2eee2a80cb796db73118c0dd09ac63fbe405be22"
 dependencies = [
  "memchr",
  "regex-automata",
@@ -264,9 +264,9 @@ checksum = "37b2a672a2cb129a2e41c10b1224bb368f9f37a2b16b612598138befd7b37eb5"
 
 [[package]]
 name = "cc"
-version = "1.2.0"
+version = "1.2.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1aeb932158bd710538c73702db6945cb68a8fb08c519e6e12706b94263b36db8"
+checksum = "fd9de9f2205d5ef3fd67e685b0df337994ddd4495e2a28d185500d0e1edfea47"
 dependencies = [
  "jobserver",
  "libc",
@@ -308,9 +308,9 @@ dependencies = [
 
 [[package]]
 name = "clap"
-version = "4.5.20"
+version = "4.5.21"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b97f376d85a664d5837dbae44bf546e6477a679ff6610010f17276f686d867e8"
+checksum = "fb3b4b9e5a7c7514dfa52869339ee98b3156b0bfb4e8a77c4ff4babb64b1604f"
 dependencies = [
  "clap_builder",
  "clap_derive",
@@ -318,9 +318,9 @@ dependencies = [
 
 [[package]]
 name = "clap_builder"
-version = "4.5.20"
+version = "4.5.21"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "19bc80abd44e4bed93ca373a0704ccbd1b710dc5749406201bb018272808dc54"
+checksum = "b17a95aa67cc7b5ebd32aa5370189aa0d79069ef1c64ce893bd30fb24bff20ec"
 dependencies = [
  "anstream",
  "anstyle",
@@ -342,9 +342,9 @@ dependencies = [
 
 [[package]]
 name = "clap_lex"
-version = "0.7.2"
+version = "0.7.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1462739cb27611015575c0c11df5df7601141071f07518d56fcc1be504cbec97"
+checksum = "afb84c814227b90d6895e01398aee0d8033c00e7466aca416fb6a8e0eb19d8a7"
 
 [[package]]
 name = "cobs"
@@ -890,9 +890,9 @@ checksum = "884e2677b40cc8c339eaefcb701c32ef1fd2493d71118dc0ca4b6a736c93bd67"
 
 [[package]]
 name = "libc"
-version = "0.2.162"
+version = "0.2.164"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "18d287de67fe55fd7e1581fe933d965a5a9477b38e949cfa9f8574ef01506398"
+checksum = "433bfe06b8c75da9b2e3fbea6e5329ff87748f0b144ef75306e674c3f6f7c13f"
 
 [[package]]
 name = "libfuzzer-sys"
@@ -1072,9 +1072,9 @@ dependencies = [
 
 [[package]]
 name = "psm"
-version = "0.1.23"
+version = "0.1.24"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "aa37f80ca58604976033fae9515a8a2989fc13797d953f7c04fb8fa36a11f205"
+checksum = "200b9ff220857e53e184257720a14553b2f4aa02577d2ed9842d45d4b9654810"
 dependencies = [
  "cc",
 ]
@@ -1246,9 +1246,9 @@ dependencies = [
 
 [[package]]
 name = "serde_json"
-version = "1.0.132"
+version = "1.0.133"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d726bfaff4b320266d395898905d0eba0345aae23b54aee3a737e260fd46db03"
+checksum = "c7fceb2473b9166b2294ef05efcb65a3db80803f0b03ef86a5fc88a2b85ee377"
 dependencies = [
  "itoa",
  "memchr",
@@ -1590,15 +1590,6 @@ dependencies = [
  "leb128",
 ]
 
-[[package]]
-name = "wasm-encoder"
-version = "0.219.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "29cbbd772edcb8e7d524a82ee8cef8dd046fc14033796a754c3ad246d019fa54"
-dependencies = [
- "leb128",
-]
-
 [[package]]
 name = "wasm-encoder"
 version = "0.220.0"
@@ -1610,16 +1601,16 @@ dependencies = [
 
 [[package]]
 name = "wasm-smith"
-version = "0.219.1"
+version = "0.220.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3b526e4c6eed409b619960258ba5bd8a3b44dfb30c75c12fce80b750a4487fcc"
+checksum = "3f7d273cf1df3c10f9067cb48796d1a6d1daa3ceb99c3f07d822e5bdeefb34f9"
 dependencies = [
  "anyhow",
  "arbitrary",
  "flagset",
  "indexmap",
  "leb128",
- "wasm-encoder 0.219.1",
+ "wasm-encoder 0.220.0",
 ]
 
 [[package]]
@@ -1734,7 +1725,7 @@ dependencies = [
  "wasm-smith",
  "wasmi 0.31.2",
  "wasmi 0.39.1",
- "wasmprinter 0.219.1",
+ "wasmprinter 0.220.0",
  "wasmtime",
 ]
 
@@ -1780,9 +1771,9 @@ dependencies = [
 
 [[package]]
 name = "wasmparser"
-version = "0.219.1"
+version = "0.220.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5c771866898879073c53b565a6c7b49953795159836714ac56a5befb581227c5"
+checksum = "e246c2772ce3ebc83f89a2d4487ac5794cad6c309b2071818a88c7db7c36d87b"
 dependencies = [
  "bitflags",
  "indexmap",
@@ -1810,13 +1801,13 @@ dependencies = [
 
 [[package]]
 name = "wasmprinter"
-version = "0.219.1"
+version = "0.220.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "228cdc1f30c27816da225d239ce4231f28941147d34713dee8f1fff7cb330e54"
+checksum = "ae749f2c66587777ce9ad0e8c632e72c77574336b17d2f040a47cffbd92198c7"
 dependencies = [
  "anyhow",
  "termcolor",
- "wasmparser 0.219.1",
+ "wasmparser 0.220.0",
 ]
 
 [[package]]
diff --git a/crates/fuzz/Cargo.toml b/crates/fuzz/Cargo.toml
index 80d3cfa404..6f87931dfe 100644
--- a/crates/fuzz/Cargo.toml
+++ b/crates/fuzz/Cargo.toml
@@ -22,10 +22,10 @@ wasmtime = { version = "26.0.0", optional = true, default-features = false, feat
     "runtime",
     "std",
 ] }
-wasm-smith = "0.219.1"
+wasm-smith = "0.220.0"
 arbitrary = "1.3.2"
 sha2 = "0.10"
-wasmprinter = { version = "0.219.1", default-features = false }
+wasmprinter = { version = "0.220.0", default-features = false }
 anyhow = "1.0.91"
 
 [features]
diff --git a/crates/fuzz/src/config.rs b/crates/fuzz/src/config.rs
index e5e4ed716e..a47fbf1270 100644
--- a/crates/fuzz/src/config.rs
+++ b/crates/fuzz/src/config.rs
@@ -104,6 +104,7 @@ impl Arbitrary<'_> for FuzzSmithConfig {
             reference_types_enabled: false, // TODO: re-enable reference-types for differential fuzzing
             simd_enabled: false,
             multi_value_enabled: true,
+            memory64_enabled: false,
             saturating_float_to_int_enabled: true,
             sign_extension_ops_enabled: true,
             relaxed_simd_enabled: false,
diff --git a/fuzz/Cargo.toml b/fuzz/Cargo.toml
index 23e282d997..a08c23b094 100644
--- a/fuzz/Cargo.toml
+++ b/fuzz/Cargo.toml
@@ -13,7 +13,7 @@ cargo-fuzz = true
 [dependencies]
 wasmi_fuzz = { workspace = true }
 wasmi = { workspace = true, features = ["std"] }
-wasm-smith = "0.219.1"
+wasm-smith = "0.220.0"
 libfuzzer-sys = "0.4.7"
 arbitrary = "1.3.2"