diff --git a/packages/compiler-core/src/transforms/vOnce.ts b/packages/compiler-core/src/transforms/vOnce.ts
index 1b58c6763b6..e1ec5e129df 100644
--- a/packages/compiler-core/src/transforms/vOnce.ts
+++ b/packages/compiler-core/src/transforms/vOnce.ts
@@ -7,7 +7,7 @@ const seen = new WeakSet()
 
 export const transformOnce: NodeTransform = (node, context) => {
   if (node.type === NodeTypes.ELEMENT && findDir(node, 'once', true)) {
-    if (seen.has(node) || context.inVOnce) {
+    if (seen.has(node) || context.inVOnce || context.inSSR) {
       return
     }
     seen.add(node)
diff --git a/packages/compiler-ssr/__tests__/ssrComponent.spec.ts b/packages/compiler-ssr/__tests__/ssrComponent.spec.ts
index 83c5bcfc3a6..9391c01e37e 100644
--- a/packages/compiler-ssr/__tests__/ssrComponent.spec.ts
+++ b/packages/compiler-ssr/__tests__/ssrComponent.spec.ts
@@ -286,6 +286,34 @@ describe('ssr: components', () => {
       `)
     })
 
+    // #7644
+    test('slot content with v-once', () => {
+      const { code } = compile(`<foo><bar v-once /></foo>`)
+      expect(code).not.toMatch(`_cache`)
+      expect(compile(`<foo><bar v-once /></foo>`).code).toMatchInlineSnapshot(`
+        "const { resolveComponent: _resolveComponent, withCtx: _withCtx, createVNode: _createVNode } = require(\\"vue\\")
+        const { ssrRenderComponent: _ssrRenderComponent } = require(\\"vue/server-renderer\\")
+
+        return function ssrRender(_ctx, _push, _parent, _attrs) {
+          const _component_foo = _resolveComponent(\\"foo\\")
+          const _component_bar = _resolveComponent(\\"bar\\")
+
+          _push(_ssrRenderComponent(_component_foo, _attrs, {
+            default: _withCtx((_, _push, _parent, _scopeId) => {
+              if (_push) {
+                _push(_ssrRenderComponent(_component_bar, null, null, _parent, _scopeId))
+              } else {
+                return [
+                  _createVNode(_component_bar)
+                ]
+              }
+            }),
+            _: 1 /* STABLE */
+          }, _parent))
+        }"
+      `)
+    })
+
     describe('built-in fallthroughs', () => {
       test('transition', () => {
         expect(compile(`<transition><div/></transition>`).code)