diff --git a/go/vt/vtctl/workflow/traffic_switcher.go b/go/vt/vtctl/workflow/traffic_switcher.go
index b762ad42f5f..65dcecb9623 100644
--- a/go/vt/vtctl/workflow/traffic_switcher.go
+++ b/go/vt/vtctl/workflow/traffic_switcher.go
@@ -1570,8 +1570,10 @@ func (ts *trafficSwitcher) findSequenceUsageInKeyspace(vschema *vschemapb.Keyspa
 				err             error
 			)
 			if len(seqTable.ColumnVindexes[i].Columns) > 0 {
-				unescapedColumn, err = sqlescape.UnescapeID(seqTable.ColumnVindexes[i].Columns[0]) // AutoIncrement definitions can only be on a single column
-				seqTable.ColumnVindexes[i].Columns[0] = unescapedColumn
+				for n := range seqTable.ColumnVindexes[i].Columns {
+					unescapedColumn, err = sqlescape.UnescapeID(seqTable.ColumnVindexes[i].Columns[n])
+					seqTable.ColumnVindexes[i].Columns[n] = unescapedColumn
+				}
 			} else {
 				// This is the legacy vschema definition.
 				unescapedColumn, err = sqlescape.UnescapeID(seqTable.ColumnVindexes[i].Column)
diff --git a/go/vt/vtctl/workflow/traffic_switcher_test.go b/go/vt/vtctl/workflow/traffic_switcher_test.go
index 495b00d7144..4b3d17036c1 100644
--- a/go/vt/vtctl/workflow/traffic_switcher_test.go
+++ b/go/vt/vtctl/workflow/traffic_switcher_test.go
@@ -284,6 +284,55 @@ func TestGetTargetSequenceMetadata(t *testing.T) {
 				},
 			},
 		},
+		{
+			name: "sequence with table having mult-col vindex",
+			sourceVSchema: &vschema.Keyspace{
+				Vindexes: vindexes,
+				Tables: map[string]*vschema.Table{
+					"seq1": {
+						Type: "sequence",
+					},
+				},
+			},
+			targetVSchema: &vschema.Keyspace{
+				Vindexes: vindexes,
+				Tables: map[string]*vschema.Table{
+					table: {
+						ColumnVindexes: []*vschema.ColumnVindex{
+							{
+								Name:    "xxhash",
+								Columns: []string{"col3", "col4"},
+							},
+						},
+						AutoIncrement: &vschema.AutoIncrement{
+							Column:   "col1",
+							Sequence: fmt.Sprintf("%s.seq1", sourceKeyspace.KeyspaceName),
+						},
+					},
+				},
+			},
+			want: map[string]*sequenceMetadata{
+				"seq1": {
+					backingTableName:     "seq1",
+					backingTableKeyspace: "source-ks",
+					backingTableDBName:   "vt_source-ks",
+					usingTableName:       unescapedTable,
+					usingTableDBName:     "vt_targetks",
+					usingTableDefinition: &vschema.Table{
+						ColumnVindexes: []*vschema.ColumnVindex{
+							{
+								Columns: []string{"col3", "col4"},
+								Name:    "xxhash",
+							},
+						},
+						AutoIncrement: &vschema.AutoIncrement{
+							Column:   "col1",
+							Sequence: fmt.Sprintf("%s.seq1", sourceKeyspace.KeyspaceName),
+						},
+					},
+				},
+			},
+		},
 		{
 			name: "invalid table name",
 			sourceVSchema: &vschema.Keyspace{