diff --git a/tortoise/contrib/mysql/fields.py b/tortoise/contrib/mysql/fields.py
index 1f5d73235..5d593e1e6 100644
--- a/tortoise/contrib/mysql/fields.py
+++ b/tortoise/contrib/mysql/fields.py
@@ -49,7 +49,7 @@ def to_db_value(self, value: Any, instance: "Union[Type[Model], Model]") -> Opti
         # If not, raise an error
         # This is to prevent UUIDv1 or any other version from being stored in the database
         if self._binary_compression:
-            if value is not isinstance(value, UUID):
+            if not isinstance(value, UUID):
                 raise ValueError("UUIDField only accepts UUID values")
             return value.bytes
         return value and str(value)