diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/support/ConstructorResolver.java b/spring-beans/src/main/java/org/springframework/beans/factory/support/ConstructorResolver.java
index b1ce9e61faf1..a30075f27318 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/support/ConstructorResolver.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/support/ConstructorResolver.java
@@ -833,14 +833,18 @@ private Object[] resolvePreparedArguments(String beanName, RootBeanDefinition mb
 				}
 				catch (BeansException ex) {
 					// Unexpected target bean mismatch for cached argument -> re-resolve
-					synchronized (descriptor) {
-						if (!descriptor.hasShortcut()) {
-							throw ex;
-						}
+					Set<String> autowiredBeanNames = null;
+					if (descriptor.hasShortcut()) {
+						// Reset shortcut and try to re-resolve it in this thread...
 						descriptor.setShortcut(null);
-						Set<String> autowiredBeanNames = new LinkedHashSet<>(2);
-						argValue = resolveAutowiredArgument(descriptor, paramType, beanName,
-								autowiredBeanNames, converter, true);
+						autowiredBeanNames = new LinkedHashSet<>(2);
+					}
+					logger.debug("Failed to resolve cached argument", ex);
+					argValue = resolveAutowiredArgument(descriptor, paramType, beanName,
+							autowiredBeanNames, converter, true);
+					if (autowiredBeanNames != null && !descriptor.hasShortcut()) {
+						// We encountered as stale shortcut before, and the shortcut has
+						// not been re-resolved by another thread in the meantime...
 						if (argValue != null) {
 							setShortcutIfPossible(descriptor, paramType, autowiredBeanNames);
 						}
diff --git a/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java b/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java
index 9170a4abe6f4..b7d89f13de04 100644
--- a/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java
+++ b/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java
@@ -446,6 +446,22 @@ public void testOptionalResourceInjectionWithSingletonRemoval() {
 		assertThat(bean.nestedTestBeansField[1]).isSameAs(ntb2);
 
 		bf.destroySingleton("testBean");
+		bf.registerSingleton("testBeanX", tb);
+
+		bean = bf.getBean("annotatedBean", OptionalResourceInjectionBean.class);
+		assertThat(bean.getTestBean()).isSameAs(tb);
+		assertThat(bean.getTestBean2()).isSameAs(tb);
+		assertThat(bean.getTestBean3()).isSameAs(tb);
+		assertThat(bean.getTestBean4()).isSameAs(tb);
+		assertThat(bean.getIndexedTestBean()).isSameAs(itb);
+		assertThat(bean.getNestedTestBeans()).hasSize(2);
+		assertThat(bean.getNestedTestBeans()[0]).isSameAs(ntb1);
+		assertThat(bean.getNestedTestBeans()[1]).isSameAs(ntb2);
+		assertThat(bean.nestedTestBeansField).hasSize(2);
+		assertThat(bean.nestedTestBeansField[0]).isSameAs(ntb1);
+		assertThat(bean.nestedTestBeansField[1]).isSameAs(ntb2);
+
+		bf.destroySingleton("testBeanX");
 
 		bean = bf.getBean("annotatedBean", OptionalResourceInjectionBean.class);
 		assertThat(bean.getTestBean()).isNull();
@@ -503,6 +519,22 @@ public void testOptionalResourceInjectionWithBeanDefinitionRemoval() {
 		assertThat(bean.nestedTestBeansField[1]).isSameAs(ntb2);
 
 		bf.removeBeanDefinition("testBean");
+		bf.registerBeanDefinition("testBeanX", new RootBeanDefinition(TestBean.class));
+
+		bean = bf.getBean("annotatedBean", OptionalResourceInjectionBean.class);
+		assertThat(bean.getTestBean()).isSameAs(bf.getBean("testBeanX"));
+		assertThat(bean.getTestBean2()).isSameAs(bf.getBean("testBeanX"));
+		assertThat(bean.getTestBean3()).isSameAs(bf.getBean("testBeanX"));
+		assertThat(bean.getTestBean4()).isSameAs(bf.getBean("testBeanX"));
+		assertThat(bean.getIndexedTestBean()).isSameAs(itb);
+		assertThat(bean.getNestedTestBeans()).hasSize(2);
+		assertThat(bean.getNestedTestBeans()[0]).isSameAs(ntb1);
+		assertThat(bean.getNestedTestBeans()[1]).isSameAs(ntb2);
+		assertThat(bean.nestedTestBeansField).hasSize(2);
+		assertThat(bean.nestedTestBeansField[0]).isSameAs(ntb1);
+		assertThat(bean.nestedTestBeansField[1]).isSameAs(ntb2);
+
+		bf.removeBeanDefinition("testBeanX");
 
 		bean = bf.getBean("annotatedBean", OptionalResourceInjectionBean.class);
 		assertThat(bean.getTestBean()).isNull();
@@ -791,6 +823,17 @@ public void testConstructorResourceInjectionWithSingletonRemoval() {
 		assertThat(bean.getBeanFactory()).isSameAs(bf);
 
 		bf.destroySingleton("nestedTestBean");
+		bf.registerSingleton("nestedTestBeanX", ntb);
+
+		bean = bf.getBean("annotatedBean", ConstructorResourceInjectionBean.class);
+		assertThat(bean.getTestBean()).isSameAs(tb);
+		assertThat(bean.getTestBean2()).isSameAs(tb);
+		assertThat(bean.getTestBean3()).isSameAs(tb);
+		assertThat(bean.getTestBean4()).isSameAs(tb);
+		assertThat(bean.getNestedTestBean()).isSameAs(ntb);
+		assertThat(bean.getBeanFactory()).isSameAs(bf);
+
+		bf.destroySingleton("nestedTestBeanX");
 
 		bean = bf.getBean("annotatedBean", ConstructorResourceInjectionBean.class);
 		assertThat(bean.getTestBean()).isSameAs(tb);
@@ -829,6 +872,17 @@ public void testConstructorResourceInjectionWithBeanDefinitionRemoval() {
 		assertThat(bean.getBeanFactory()).isSameAs(bf);
 
 		bf.removeBeanDefinition("nestedTestBean");
+		bf.registerBeanDefinition("nestedTestBeanX", new RootBeanDefinition(NestedTestBean.class));
+
+		bean = bf.getBean("annotatedBean", ConstructorResourceInjectionBean.class);
+		assertThat(bean.getTestBean()).isSameAs(tb);
+		assertThat(bean.getTestBean2()).isSameAs(tb);
+		assertThat(bean.getTestBean3()).isSameAs(tb);
+		assertThat(bean.getTestBean4()).isSameAs(tb);
+		assertThat(bean.getNestedTestBean()).isSameAs(bf.getBean("nestedTestBeanX"));
+		assertThat(bean.getBeanFactory()).isSameAs(bf);
+
+		bf.removeBeanDefinition("nestedTestBeanX");
 
 		bean = bf.getBean("annotatedBean", ConstructorResourceInjectionBean.class);
 		assertThat(bean.getTestBean()).isSameAs(tb);