diff --git a/starfish/core/segmentation_mask/segmentation_mask.py b/starfish/core/segmentation_mask/segmentation_mask.py
index 1329fdb1d..a54095a5d 100644
--- a/starfish/core/segmentation_mask/segmentation_mask.py
+++ b/starfish/core/segmentation_mask/segmentation_mask.py
@@ -1,5 +1,7 @@
 import io
+import itertools
 import tarfile
+from dataclasses import dataclass
 from typing import (
     cast,
     Dict,
@@ -17,6 +19,7 @@
 import numpy as np
 import xarray as xr
 from skimage.measure import regionprops
+from skimage.measure._regionprops import _RegionProperties
 
 from starfish.core.types import Axes, Coordinates
 from .expand import fill_from_mask
@@ -50,6 +53,12 @@ def _validate_segmentation_mask(arr: xr.DataArray):
         raise TypeError(f"missing coordinates '{dims.union(coords).difference(arr.coords)}'")
 
 
+@dataclass
+class MaskData:
+    binary_mask: xr.DataArray
+    region_properties: Optional[_RegionProperties]
+
+
 class SegmentationMaskCollection:
     """Collection of binary segmentation masks with a dict-like access pattern.
 
@@ -57,23 +66,32 @@ class SegmentationMaskCollection:
     ----------
     masks : Iterable[xr.DataArray]
         Segmentation masks.
+    props : Iterable[_RegionProperties]
+        Properties for each of the regions in the masks.
 
     Attributes
     ----------
     max_shape : Dict[Axes, Optional[int]]
         Maximum index of contained masks.
     """
-    def __init__(self, masks: Iterable[xr.DataArray]):
-        self._masks: MutableMapping[int, xr.DataArray] = {}
+    def __init__(
+            self,
+            masks: Iterable[xr.DataArray],
+            props: Optional[Iterable[Optional[_RegionProperties]]] = None,
+    ):
+        if props is None:
+            props = itertools.cycle((None,))
+        self._masks: MutableMapping[int, MaskData] = {}
         self.max_shape: Dict[Axes, int] = {
             Axes.X: 0,
             Axes.Y: 0,
             Axes.ZPLANE: 0
         }
 
-        for ix, mask in enumerate(masks):
+        for ix, (mask, mask_props) in enumerate(zip(masks, props)):
             _validate_segmentation_mask(mask)
-            self._masks[ix] = mask
+
+            self._masks[ix] = MaskData(mask, mask_props)
 
             for axis in Axes:
                 if axis.value in mask.coords:
@@ -82,16 +100,49 @@ def __init__(self, masks: Iterable[xr.DataArray]):
                         self.max_shape[axis] = max_val + 1
 
     def __getitem__(self, index: int) -> xr.DataArray:
-        return self._masks[index]
+        return self._masks[index].binary_mask
 
     def __iter__(self) -> Iterator[Tuple[int, xr.DataArray]]:
-        return iter(self._masks.items())
+        for mask_index, mask_data in self._masks.items():
+            yield mask_index, mask_data.binary_mask
 
     def __len__(self) -> int:
         return len(self._masks)
 
     def masks(self) -> Iterator[xr.DataArray]:
-        return iter(self._masks.values())
+        for mask_index, mask_data in self._masks.items():
+            yield mask_data.binary_mask
+
+    def mask_regionprops(self, mask_id: int) -> _RegionProperties:
+        """
+        Return the region properties for
+        Parameters
+        ----------
+        mask_id
+
+        Returns
+        -------
+
+        """
+        mask_data = self._masks[mask_id]
+        if mask_data.region_properties is None:
+            # recreate the label image (but with just this mask)
+            image = np.zeros(
+                shape=tuple(
+                    self.max_shape[axis]
+                    for axis in AXES_ORDER
+                    if self.max_shape[axis] != 0
+                ),
+                dtype=np.uint32,
+            )
+            fill_from_mask(
+                mask_data.binary_mask,
+                mask_id + 1,
+                image,
+                [axis for axis in AXES_ORDER if self.max_shape[axis] > 0],
+            )
+            mask_data.region_properties = regionprops(image)
+        return mask_data.region_properties
 
     @classmethod
     def from_label_image(
@@ -143,7 +194,7 @@ def from_label_image(
                                 name=name)
             masks.append(mask)
 
-        return cls(masks)
+        return cls(masks, props)
 
     def to_label_image(
             self,
diff --git a/starfish/core/segmentation_mask/test/test_segmentation_mask.py b/starfish/core/segmentation_mask/test/test_segmentation_mask.py
index 26137adf1..bfa4e5a63 100644
--- a/starfish/core/segmentation_mask/test/test_segmentation_mask.py
+++ b/starfish/core/segmentation_mask/test/test_segmentation_mask.py
@@ -138,3 +138,9 @@ def test_save_load():
             assert np.array_equal(m, m2)
     finally:
         os.remove(path)
+
+    # ensure that the regionprops are equal
+    for ix in range(len(masks)):
+        original_props = masks.mask_regionprops(ix)
+        recalculated_props = masks.mask_regionprops(ix)
+        assert original_props == recalculated_props