diff --git a/biotrainer/config/configurator.py b/biotrainer/config/configurator.py
index d887caa2..56ba4529 100644
--- a/biotrainer/config/configurator.py
+++ b/biotrainer/config/configurator.py
@@ -1,15 +1,11 @@
 import os
 from pathlib import Path
 from typing import Union, List, Dict, Any, Tuple
-from datasets import load_dataset, concatenate_datasets
-from sklearn.model_selection import train_test_split
 
 from ruamel import yaml
 from ruamel.yaml import YAMLError
-from webencodings import labels
 
-from . import config_rules
-from .config_option import ConfigurationException, ConfigOption, FileOption, logger
+from .config_option import ConfigurationException, ConfigOption, FileOption
 from .config_rules import (
     ConfigRule,
     MutualExclusive,
diff --git a/biotrainer/config/embedding_options.py b/biotrainer/config/embedding_options.py
index 61a1eeee..3ba638b7 100644
--- a/biotrainer/config/embedding_options.py
+++ b/biotrainer/config/embedding_options.py
@@ -4,6 +4,7 @@
 
 from .config_option import FileOption, classproperty, ConfigOption
 from ..embedders import get_predefined_embedder_names
+from ..protocols import Protocol
 
 
 class EmbeddingOption(ConfigOption, ABC):
@@ -144,5 +145,59 @@ def allow_download(self) -> bool:
         return True
 
 
-# List of all embedding-related configuration options
-embedding_options: List[Type[EmbeddingOption]] = [EmbedderName, UseHalfPrecision, EmbeddingsFile]
+class DimensionReductionMethod(EmbeddingOption, ConfigOption):
+
+    @classproperty
+    def name(self) -> str:
+        return "dimension_reduction_method"
+
+    @property
+    def default_value(self) -> Union[str, int, float, bool, Any]:
+        return ""
+
+    @classproperty
+    def allow_multiple_values(self) -> bool:
+        return False
+
+    @property
+    def possible_values(self) -> List[Any]:
+        return ["umap", "tsne"]
+
+    @classproperty
+    def allowed_protocols(self) -> List[Protocol]:
+        return Protocol.using_per_sequence_embeddings()
+
+    @classproperty
+    def required(self) -> bool:
+        return False
+
+
+class NReducedComponents(EmbeddingOption, ConfigOption):
+
+    @classproperty
+    def name(self) -> str:
+        return "n_reduced_components"
+
+    @property
+    def default_value(self) -> Union[str, int, float, bool, Any]:
+        return ""
+
+    @classproperty
+    def allow_multiple_values(self) -> bool:
+        return False
+
+    @staticmethod
+    def _is_value_valid(config_option: ConfigOption, value) -> bool:
+        return type(value)==int and value > 0
+
+    @classproperty
+    def allowed_protocols(self) -> List[Protocol]:
+        return Protocol.using_per_sequence_embeddings()
+
+    @classproperty
+    def required(self) -> bool:
+        return False
+
+
+embedding_options: List[Type[EmbeddingOption]] = [EmbedderName, UseHalfPrecision, EmbeddingsFile,
+                                                  DimensionReductionMethod, NReducedComponents]
diff --git a/biotrainer/config/general_options.py b/biotrainer/config/general_options.py
index 35e1cad1..d3af374a 100644
--- a/biotrainer/config/general_options.py
+++ b/biotrainer/config/general_options.py
@@ -134,7 +134,7 @@ def possible_values(self) -> List[Any]:
 
     @classproperty
     def allowed_protocols(self) -> List[Protocol]:
-        return [Protocol.sequence_to_class, Protocol.sequence_to_value]
+        return Protocol.using_per_sequence_embeddings()
 
     @classproperty
     def required(self) -> bool:
diff --git a/biotrainer/embedders/embedding_service.py b/biotrainer/embedders/embedding_service.py
index 97c0d1eb..e80a4f07 100644
--- a/biotrainer/embedders/embedding_service.py
+++ b/biotrainer/embedders/embedding_service.py
@@ -1,16 +1,18 @@
 import os
 import gc
 import time
-import psutil
 import h5py
 import torch
+import psutil
 import logging
 import numpy as np
 
+from umap import UMAP
 from tqdm import tqdm
 from pathlib import Path
 from numpy import ndarray
-from typing import Dict, Tuple, Any, Optional, List, Union
+from sklearn.manifold import TSNE
+from typing import Dict, Tuple, Any, List, Union, Optional
 
 from .embedder_interfaces import EmbedderInterface
 
@@ -230,6 +232,46 @@ def _save_and_reset_embeddings(self, embeddings: Dict[str, ndarray], last_save_i
         del embeddings
         return last_save_id, {}
 
+    @staticmethod
+    def embeddings_dimensionality_reduction(
+            embeddings: Dict[str, Any],
+            dimension_reduction_method: str,
+            n_reduced_components: int) -> Dict[str, Any]:
+        """Reduces the dimension of per-protein embeddings using one of the
+        dimensionality reduction methods
+
+        Args:
+            embeddings (Dict[str, Any]): Dictionary of embeddings.
+            dimension_reduction_method (str): The method used to reduce 
+            the dimensionality of embeddings. Options are 'umap' or 'tsne'.
+            n_reduced_components (int): The target number of dimensions for 
+            the reduced embeddings.
+
+        Returns:
+            Dict[str, Any]: Dictionary of embeddings with reduced dimensions.
+        """
+        sorted_keys = sorted(list(embeddings.keys()))
+        all_embeddings = torch.stack([embeddings[k] for k in sorted_keys], dim=0)
+        max_dim_dict = {
+            "umap": all_embeddings.shape[0] - 2,
+            "tsne": all_embeddings.shape[0] - 1
+        }
+        n_reduced_components = min([
+            n_reduced_components,
+            max_dim_dict[dimension_reduction_method],
+            all_embeddings.shape[1]])
+        dimension_reduction_method_dict = {
+            "umap": UMAP(n_components=n_reduced_components),
+            "tsne": TSNE(
+                n_components=n_reduced_components,
+                perplexity=min(30, n_reduced_components))
+        }
+        logger.info(f"Starting embeddings dimensionality reduction via method {dimension_reduction_method}")
+        embeddings_reduced_dimensions = dimension_reduction_method_dict[
+            dimension_reduction_method].fit_transform(all_embeddings)
+        logger.info(f"Finished embeddings dimensionality reduction!")
+        return {sorted_keys[i]: torch.tensor(embeddings_reduced_dimensions[i]) for i in range(len(sorted_keys))}
+
     @staticmethod
     def _reduce_embeddings(embeddings: Dict[str, ndarray], embedder) -> Dict[str, ndarray]:
         """
diff --git a/biotrainer/trainers/trainer.py b/biotrainer/trainers/trainer.py
index aa843f3a..fa02952a 100644
--- a/biotrainer/trainers/trainer.py
+++ b/biotrainer/trainers/trainer.py
@@ -51,6 +51,8 @@ def __init__(self,
                  cross_validation_config: Dict[str, Any] = None,
                  interaction: Optional[str] = None,
                  sanity_check: bool = True,
+                 dimension_reduction_method: Optional[str] = None,
+                 n_reduced_components: Optional[int] = None,
                  # Ignore rest
                  **kwargs
                  ):
@@ -76,6 +78,8 @@ def __init__(self,
         self._cross_validation_splitter = CrossValidationSplitter(self._protocol, self._cross_validation_config)
         self._hp_manager = hp_manager
         self._sanity_check = sanity_check
+        self._dimension_reduction_method = dimension_reduction_method
+        self._n_reduced_components = n_reduced_components
 
     def training_and_evaluation_routine(self):
         # SETUP
@@ -173,9 +177,36 @@ def _create_and_load_embeddings(self) -> Dict[str, Any]:
 
         # Mapping from id to embeddings
         id2emb = embedding_service.load_embeddings(embeddings_file_path=embeddings_file)
-
+        if self._is_dimension_reduction_possible(id2emb):
+            id2emb = embedding_service.embeddings_dimensionality_reduction(
+                embeddings=id2emb,
+                dimension_reduction_method=self._dimension_reduction_method,
+                n_reduced_components=self._n_reduced_components)
         return id2emb
 
+    def _is_dimension_reduction_possible(self, embeddings: Dict[str, Any]) -> bool:
+        if (self._protocol.using_per_sequence_embeddings() and
+            self._dimension_reduction_method and 
+            self._n_reduced_components and
+            len(embeddings)>=3 and
+            list(embeddings.values())[0].shape[0]>=3):
+            return True
+        else:
+            if (self._dimension_reduction_method and
+                self._n_reduced_components):
+                if len(embeddings)<3:
+                    raise Exception(f"Dimensionality reduction cannot be performed as \
+                                the number of samples is less than 3")
+                if list(embeddings.values())[0].shape[0]<3:
+                    raise Exception(f"Dimensionality reduction cannot be performed as \
+                                the original embedding dimension is less than 3")
+                if not self._protocol.using_per_sequence_embeddings():
+                    raise Exception(f"Dimensionality reduction cannot be performed as \
+                                the embeddings are not per-protein embeddings")
+            return False
+
+
+
     def _get_class_weights(self, target_manager: TargetManager) -> Union[None, torch.FloatTensor]:
         # Get x_to_class specific logs and weights
         class_weights = None
diff --git a/docs/config_file_options.md b/docs/config_file_options.md
index a1cc0f6b..3d92c350 100644
--- a/docs/config_file_options.md
+++ b/docs/config_file_options.md
@@ -136,6 +136,15 @@ The file will be downloaded and stored in the path of your config file with pref
 **Note that *embedder_name* and *embeddings_file* are mutually exclusive. In case you provide your own embeddings,
 the experiment directory will be called *custom_embeddings*.**
 
+To perform dimensionality reduction on the embeddings, specify the dimension reduction method to be used:
+```yaml
+dimension_reduction_method: umap | tsne # Default: None
+```
+and the number of dimensions to reduce the embeddings to (any positive integer):
+```yaml
+n_reduced_components: 5 # Default: None
+```
+
 ## Model parameters
 
 There are multiple options available to specify the model you want to train.
diff --git a/examples/sequence_to_class_dim_reduction/.gitignore b/examples/sequence_to_class_dim_reduction/.gitignore
new file mode 100644
index 00000000..8080f735
--- /dev/null
+++ b/examples/sequence_to_class_dim_reduction/.gitignore
@@ -0,0 +1,2 @@
+output/
+out.yml
\ No newline at end of file
diff --git a/examples/sequence_to_class_dim_reduction/README.md b/examples/sequence_to_class_dim_reduction/README.md
new file mode 100644
index 00000000..4d38b8bd
--- /dev/null
+++ b/examples/sequence_to_class_dim_reduction/README.md
@@ -0,0 +1,13 @@
+# sequence_to_class_dim_reduction example
+
+This example shows how to use the sequence_to_class protocol with embeddings dimensionality reduction. It predicts a class for every sequence with reduced dimension in the
+sequences.fasta file. Class labels and dataset annotations are also stored in the sequences.fasta file 
+for this protocol (see [data standardization](../../docs/data_standardization.md#sequence_to_class)).
+
+Additionally, in this example the `use_class_weights: True` flag is set, 
+which can also be used to get a quick overview about the class distribution in your dataset from the console logs.
+
+Execute the example (from the base directory):
+```bash
+poetry run python3 run-biotrainer.py examples/sequence_to_class_dim_reduction/config.yml
+```
diff --git a/examples/sequence_to_class_dim_reduction/config.yml b/examples/sequence_to_class_dim_reduction/config.yml
new file mode 100644
index 00000000..b2c713d4
--- /dev/null
+++ b/examples/sequence_to_class_dim_reduction/config.yml
@@ -0,0 +1,16 @@
+sequence_file: sequences.fasta
+protocol: sequence_to_class
+model_choice: FNN
+optimizer_choice: adam
+loss_choice: cross_entropy_loss
+num_epochs: 200
+use_class_weights: True
+learning_rate: 1e-3
+batch_size: 128
+save_split_ids: False
+use_half_precision: True
+device: cuda
+disable_pytorch_compile: True
+embedder_name: Rostlab/prot_t5_xl_uniref50
+dimension_reduction_method: umap
+n_reduced_components: 3
\ No newline at end of file
diff --git a/examples/sequence_to_class_dim_reduction/sequences.fasta b/examples/sequence_to_class_dim_reduction/sequences.fasta
new file mode 100644
index 00000000..cd0e3c58
--- /dev/null
+++ b/examples/sequence_to_class_dim_reduction/sequences.fasta
@@ -0,0 +1,8 @@
+>Seq1 TARGET=Glob SET=train
+SEQWENCE
+>Seq2 TARGET=GlobSP SET=val
+PRTEIN
+>Seq3 TARGET=TM SET=test
+SEQVENCEPROTEI
+>Seq4 TARGET=TMSP SET=test
+PRTEINSEQWENCE
\ No newline at end of file
diff --git a/pyproject.toml b/pyproject.toml
index 322d6381..c62085b5 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -57,6 +57,7 @@ onnxscript = "^0.1.0.dev20240806"
 onnxruntime = "^1.19.0"
 pandas = "^2.2.3"
 datasets = "^3.1.0"
+umap-learn = "^0.5.7"
 
 [tool.poetry.dev-dependencies]
 pytest = "^8.3.3"
diff --git a/tests/test_configurations.py b/tests/test_configurations.py
index eb8bec89..f82cdb7b 100644
--- a/tests/test_configurations.py
+++ b/tests/test_configurations.py
@@ -527,4 +527,73 @@ def test_hf_mutual_exclusive_mask_file_name(self):
                 "mutual exclusive",
                 str(context.exception),
                 "Exception does not raise an exception for mutual exclusive mask file name."
-            )
\ No newline at end of file
+            )
+
+    def test_dimension_reduction_methods(self):
+        with tempfile.TemporaryDirectory() as tmpdir:
+            config_dict = deepcopy(configurations["minimal"])
+            # Existing method works
+            config_dict["dimension_reduction_method"] = "umap"
+
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            self.assertTrue(
+                configurator.get_verified_config(),
+                "Valid dimension_reduction_method: umap failed!"
+            )
+
+            # Non-existing method does not work
+            config_dict["dimension_reduction_method"] = "nonexistingmethod"
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            with self.assertRaises(ConfigurationException) as context:
+                configurator.get_verified_config()
+
+    def test_dimension_reduction_components(self):
+        with tempfile.TemporaryDirectory() as tmpdir:
+            config_dict = deepcopy(configurations["minimal"])
+            # Positive integer works
+            config_dict["dimension_reduction_method"] = "umap"
+            config_dict["n_reduced_components"] = 23
+
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            self.assertTrue(
+                configurator.get_verified_config(),
+                "Valid n_reduced_components: 5 failed"
+            )
+
+            # Zero does not work
+            config_dict["n_reduced_components"] = 0
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            with self.assertRaises(ConfigurationException) as context:
+                configurator.get_verified_config()
+
+            # Negative integer does not work
+            config_dict["n_reduced_components"] = -50
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            with self.assertRaises(ConfigurationException) as context:
+                configurator.get_verified_config()
+
+            # Double value does not work
+            config_dict["n_reduced_components"] = 5.5
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            with self.assertRaises(ConfigurationException) as context:
+                configurator.get_verified_config()
+
+            # Negative double value does not work
+            config_dict["n_reduced_components"] = -10.25
+            configurator = Configurator.from_config_dict(config_dict)
+            configurator._config_file_path = Path(tmpdir)
+
+            with self.assertRaises(ConfigurationException) as context:
+                configurator.get_verified_config()
\ No newline at end of file