diff --git a/lib/chain.js b/lib/chain.js
index f1fc5caf..4e32d0c3 100644
--- a/lib/chain.js
+++ b/lib/chain.js
@@ -140,7 +140,7 @@ Chain.prototype.run = function run(req, res, done) {
         var handler = self._stack[index++];
 
         // all done or request closed
-        if (!handler || req.connectionState() === 'close') {
+        if (!handler || req.connectionState() === 'close' || res.destroyed) {
             process.nextTick(function nextTick() {
                 return done(err, req, res);
             });
diff --git a/test/server.test.js b/test/server.test.js
index 5fd10806..d1e53b1a 100644
--- a/test/server.test.js
+++ b/test/server.test.js
@@ -3057,3 +3057,22 @@ test('should use custom function for error handling', function(t) {
         });
     });
 });
+
+test('should stop the chain when response already destroyed', function(t) {
+    let counter = 0;
+    SERVER.get(
+        '/test',
+        async function test(req, res) {
+            counter++;
+            res.send();
+        },
+        async function test(req, res) {
+            counter++;
+            res.send();
+        }
+    );
+    CLIENT.get('/test', function() {
+        t.equal(counter, 1);
+        t.end();
+    });
+});