diff --git a/docs/usage/configuration-options.md b/docs/usage/configuration-options.md
index 9fd548a998c7d6..d3bddbf4ebf364 100644
--- a/docs/usage/configuration-options.md
+++ b/docs/usage/configuration-options.md
@@ -2510,6 +2510,8 @@ Invalid if used outside of a `packageRule`.
 
 ### excludeDepPatterns
 
+### excludeDepPrefixes
+
 ### excludePackageNames
 
 **Important**: Do not mix this up with the option `ignoreDeps`.
@@ -2830,6 +2832,8 @@ It is recommended that you avoid using "negative" globs, like `**/!(package.json
 
 ### matchDepPatterns
 
+### matchDepPrefixes
+
 ### matchNewValue
 
 This option is matched against the `newValue` field of a dependency.
diff --git a/lib/config/options/index.ts b/lib/config/options/index.ts
index d40a1ed85abe1f..9601bca00b0502 100644
--- a/lib/config/options/index.ts
+++ b/lib/config/options/index.ts
@@ -1375,6 +1375,34 @@ const options: RenovateOptions[] = [
     cli: false,
     env: false,
   },
+  {
+    name: 'matchDepPrefixes',
+    description:
+      'Dep names prefixes to match. Valid only within a `packageRules` object.',
+    type: 'array',
+    subType: 'string',
+    allowString: true,
+    stage: 'package',
+    parents: ['packageRules'],
+    mergeable: true,
+    cli: false,
+    env: false,
+    advancedUse: true,
+  },
+  {
+    name: 'excludeDepPrefixes',
+    description:
+      'Dep names prefixes to exclude. Valid only within a `packageRules` object.',
+    type: 'array',
+    subType: 'string',
+    allowString: true,
+    stage: 'package',
+    parents: ['packageRules'],
+    mergeable: true,
+    cli: false,
+    env: false,
+    advancedUse: true,
+  },
   {
     name: 'matchPackagePatterns',
     description:
diff --git a/lib/config/types.ts b/lib/config/types.ts
index 6c68f35093a84a..2e55575c98927a 100644
--- a/lib/config/types.ts
+++ b/lib/config/types.ts
@@ -353,6 +353,7 @@ export interface PackageRule
   description?: string | string[];
   excludeDepNames?: string[];
   excludeDepPatterns?: string[];
+  excludeDepPrefixes?: string[];
   excludePackageNames?: string[];
   excludePackagePatterns?: string[];
   excludePackagePrefixes?: string[];
@@ -367,6 +368,7 @@ export interface PackageRule
   matchDatasources?: string[];
   matchDepNames?: string[];
   matchDepPatterns?: string[];
+  matchDepPrefixes?: string[];
   matchDepTypes?: string[];
   matchFileNames?: string[];
   matchManagers?: string[];
diff --git a/lib/config/validation.ts b/lib/config/validation.ts
index 4ad370482ce52a..e12b7fb67bf816 100644
--- a/lib/config/validation.ts
+++ b/lib/config/validation.ts
@@ -396,11 +396,13 @@ export async function validateConfig(
               'matchDepTypes',
               'matchDepNames',
               'matchDepPatterns',
+              'matchDepPrefixes',
               'matchPackageNames',
               'matchPackagePatterns',
               'matchPackagePrefixes',
               'excludeDepNames',
               'excludeDepPatterns',
+              'excludeDepPrefixes',
               'excludePackageNames',
               'excludePackagePatterns',
               'excludePackagePrefixes',
diff --git a/lib/util/package-rules/dep-prefixes.spec.ts b/lib/util/package-rules/dep-prefixes.spec.ts
new file mode 100644
index 00000000000000..d5b35da075989d
--- /dev/null
+++ b/lib/util/package-rules/dep-prefixes.spec.ts
@@ -0,0 +1,105 @@
+import { DepPrefixesMatcher } from './dep-prefixes';
+
+describe('util/package-rules/dep-prefixes', () => {
+  const depPrefixesMatcher = new DepPrefixesMatcher();
+
+  describe('match', () => {
+    it('should return null if matchDepPrefixes is not defined', () => {
+      const result = depPrefixesMatcher.matches(
+        {
+          depName: 'abc1',
+        },
+        {
+          matchDepPrefixes: undefined,
+        },
+      );
+      expect(result).toBeNull();
+    });
+
+    it('should return false if depName is not defined', () => {
+      const result = depPrefixesMatcher.matches(
+        {
+          depName: undefined,
+        },
+        {
+          matchDepPrefixes: ['@opentelemetry'],
+        },
+      );
+      expect(result).toBeFalse();
+    });
+
+    it('should return true if depName matched', () => {
+      const result = depPrefixesMatcher.matches(
+        {
+          depName: 'abc1',
+        },
+        {
+          matchDepPrefixes: ['abc'],
+        },
+      );
+      expect(result).toBeTrue();
+    });
+
+    it('should return false if depName does not match', () => {
+      const result = depPrefixesMatcher.matches(
+        {
+          depName: 'abc1',
+        },
+        {
+          matchDepPrefixes: ['def'],
+        },
+      );
+      expect(result).toBeFalse();
+    });
+  });
+
+  describe('exclude', () => {
+    it('should return null if excludeDepPrefixes is not defined', () => {
+      const result = depPrefixesMatcher.excludes(
+        {
+          depName: 'abc1',
+        },
+        {
+          excludeDepPrefixes: undefined,
+        },
+      );
+      expect(result).toBeNull();
+    });
+
+    it('should return false if depName is not defined', () => {
+      const result = depPrefixesMatcher.excludes(
+        {
+          depName: undefined,
+        },
+        {
+          excludeDepPrefixes: ['@opentelemetry'],
+        },
+      );
+      expect(result).toBeFalse();
+    });
+
+    it('should return true if depName matched', () => {
+      const result = depPrefixesMatcher.excludes(
+        {
+          depName: 'abc1',
+        },
+        {
+          excludeDepPrefixes: ['abc'],
+        },
+      );
+      expect(result).toBeTrue();
+    });
+
+    it('should return false if depName does not match', () => {
+      const result = depPrefixesMatcher.excludes(
+        {
+          depName: 'abc1',
+        },
+        {
+          excludeDepPrefixes: ['def'],
+        },
+      );
+      expect(result).toBeFalse();
+    });
+  });
+});
diff --git a/lib/util/package-rules/dep-prefixes.ts b/lib/util/package-rules/dep-prefixes.ts
new file mode 100644
index 00000000000000..351df41f8605e5
--- /dev/null
+++ b/lib/util/package-rules/dep-prefixes.ts
@@ -0,0 +1,35 @@
+import is from '@sindresorhus/is';
+import type { PackageRule, PackageRuleInputConfig } from '../../config/types';
+import { Matcher } from './base';
+
+export class DepPrefixesMatcher extends Matcher {
+  override matches(
+    { depName }: PackageRuleInputConfig,
+    { matchDepPrefixes }: PackageRule,
+  ): boolean | null {
+    if (is.undefined(matchDepPrefixes)) {
+      return null;
+    }
+
+    if (is.undefined(depName)) {
+      return false;
+    }
+
+    return matchDepPrefixes.some((prefix) => depName.startsWith(prefix));
+  }
+
+  override excludes(
+    { depName }: PackageRuleInputConfig,
+    { excludeDepPrefixes }: PackageRule,
+  ): boolean | null {
+    if (is.undefined(excludeDepPrefixes)) {
+      return null;
+    }
+
+    if (is.undefined(depName)) {
+      return false;
+    }
+
+    return excludeDepPrefixes.some((prefix) => depName.startsWith(prefix));
+  }
+}
diff --git a/lib/util/package-rules/index.spec.ts b/lib/util/package-rules/index.spec.ts
index 80e5716ee7a9ce..6a6a7dc01407ba 100644
--- a/lib/util/package-rules/index.spec.ts
+++ b/lib/util/package-rules/index.spec.ts
@@ -1230,4 +1230,52 @@ describe('util/package-rules/index', () => {
     expect(res1.x).toBeUndefined();
     expect(res2.x).toBe(1);
   });
+
+  it('matches matchDepPrefixes(depName)', () => {
+    const config: TestConfig = {
+      packageRules: [
+        {
+          matchDepPrefixes: ['abc'],
+          x: 1,
+        },
+      ],
+    };
+
+    const res1 = applyPackageRules({
+      ...config,
+      depName: 'abc1',
+    });
+    const res2 = applyPackageRules({
+      ...config,
+      depName: 'def1',
+    });
+    applyPackageRules(config); // coverage
+
+    expect(res1.x).toBe(1);
+    expect(res2.x).toBeUndefined();
+  });
+
+  it('matches excludeDepPrefixes(depName)', () => {
+    const config: TestConfig = {
+      packageRules: [
+        {
+          excludeDepPrefixes: ['abc'],
+          x: 1,
+        },
+      ],
+    };
+
+    const res1 = applyPackageRules({
+      ...config,
+      depName: 'abc1',
+    });
+    const res2 = applyPackageRules({
+      ...config,
+      depName: 'def1',
+    });
+    applyPackageRules(config); // coverage
+
+    expect(res1.x).toBeUndefined();
+    expect(res2.x).toBe(1);
+  });
 });
diff --git a/lib/util/package-rules/matchers.ts b/lib/util/package-rules/matchers.ts
index 4bef5c5784eb5e..80a0d19ff7c171 100644
--- a/lib/util/package-rules/matchers.ts
+++ b/lib/util/package-rules/matchers.ts
@@ -6,6 +6,7 @@ import { CurrentVersionMatcher } from './current-version';
 import { DatasourcesMatcher } from './datasources';
 import { DepNameMatcher } from './dep-names';
 import { DepPatternsMatcher } from './dep-patterns';
+import { DepPrefixesMatcher } from './dep-prefixes';
 import { DepTypesMatcher } from './dep-types';
 import { FileNamesMatcher } from './files';
 import { ManagersMatcher } from './managers';
@@ -32,6 +33,7 @@ matchers.push([new MergeConfidenceMatcher()]);
 matchers.push([
   new DepNameMatcher(),
   new DepPatternsMatcher(),
+  new DepPrefixesMatcher(),
   new PackageNameMatcher(),
   new PackagePatternsMatcher(),
   new PackagePrefixesMatcher(),