diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 7ee3cc4e7..aa076e6be 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -22,17 +22,8 @@ repos:
       hooks:
           - id: black
             args: ["--config=python/pyproject.toml"]
-    - repo: https://github.com/PyCQA/flake8
-      rev: 5.0.4
-      hooks:
-          - id: flake8
-            args: ["--config=python/.flake8"]
-            files: python/.*$
-            types: [file]
-            types_or: [python, cython]
-            additional_dependencies: ["flake8-force"]
     - repo: https://github.com/MarcoGorelli/cython-lint
-      rev: v0.1.10
+      rev: v0.15.0
       hooks:
           - id: cython-lint
     - repo: https://github.com/pre-commit/mirrors-clang-format
@@ -78,6 +69,11 @@ repos:
               # of dependencies, so we'll have to update this manually.
               additional_dependencies:
                 - cmakelang==0.6.13
+    - repo: https://github.com/astral-sh/ruff-pre-commit
+      rev: v0.0.278
+      hooks:
+        - id: ruff
+          files: python/.*$
 
 default_language_version:
     python: python3
diff --git a/pyproject.toml b/pyproject.toml
index 8a412773e..285098f99 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -7,3 +7,16 @@ ignore-regex = "\\b(.{1,4}|[A-Z]\\w*T)\\b"
 ignore-words-list = "inout"
 builtin = "clear"
 quiet-level = 3
+
+[tool.ruff]
+select = ["E", "F", "W"]
+ignore = [
+    # whitespace before :
+    "E203",
+]
+fixable = ["ALL"]
+exclude = [
+    # TODO: Remove this in a follow-up where we fix __all__.
+    "__init__.py",
+]
+line-length = 79
diff --git a/python/.flake8 b/python/.flake8
deleted file mode 100644
index 4d610ba8e..000000000
--- a/python/.flake8
+++ /dev/null
@@ -1,24 +0,0 @@
-# Copyright (c) 2023, NVIDIA CORPORATION.
-
-[flake8]
-filename = *.py, *.pyx, *.pxd, *.pxi
-exclude = __init__.py, *.egg, build, docs, .git
-force-check = True
-ignore =
-    # line break before binary operator
-    W503,
-    # whitespace before :
-    E203
-per-file-ignores =
-    # Rules ignored only in Cython:
-    # E211: whitespace before '(' (used in multi-line imports)
-    # E225: Missing whitespace around operators (breaks cython casting syntax like <int>)
-    # E226: Missing whitespace around arithmetic operators (breaks cython pointer syntax like int*)
-    # E227: Missing whitespace around bitwise or shift operator (Can also break casting syntax)
-    # E275: Missing whitespace after keyword (Doesn't work with Cython except?)
-    # E402: invalid syntax (works for Python, not Cython)
-    # E999: invalid syntax (works for Python, not Cython)
-    # W504: line break after binary operator (breaks lines that end with a pointer)
-    *.pyx: E211, E225, E226, E227, E275, E402, E999, W504
-    *.pxd: E211, E225, E226, E227, E275, E402, E999, W504
-    *.pxi: E211, E225, E226, E227, E275, E402, E999, W504