diff --git a/python/cudf/cudf/core/dataframe.py b/python/cudf/cudf/core/dataframe.py
index 48c1f49e6ea..30b6c307fbd 100644
--- a/python/cudf/cudf/core/dataframe.py
+++ b/python/cudf/cudf/core/dataframe.py
@@ -7953,7 +7953,7 @@ def _setitem_with_dataframe(
             "Number of Input Columns must be same replacement Dataframe"
         )
 
-    if not input_df.index.equals(replace_df.index):
+    if len(input_df) != 0 and not input_df.index.equals(replace_df.index):
         replace_df = replace_df.reindex(input_df.index)
 
     for col_1, col_2 in zip(input_cols, replace_df.columns):
diff --git a/python/cudf/cudf/tests/test_dataframe.py b/python/cudf/cudf/tests/test_dataframe.py
index f068d02d575..810eabdf699 100644
--- a/python/cudf/cudf/tests/test_dataframe.py
+++ b/python/cudf/cudf/tests/test_dataframe.py
@@ -1070,6 +1070,13 @@ def test_dataframe_setitem_index_len1():
     np.testing.assert_equal(gdf.b.to_array(), [0])
 
 
+def test_empty_dataframe_setitem_df():
+    gdf1 = cudf.DataFrame()
+    gdf2 = cudf.DataFrame({"a": [1, 2, 3, 4, 5]})
+    gdf1["a"] = gdf2["a"]
+    assert_eq(gdf1, gdf2)
+
+
 def test_assign():
     gdf = cudf.DataFrame({"x": [1, 2, 3]})
     gdf2 = gdf.assign(y=gdf.x + 1)