diff --git a/ci/build_wheel_cudf.sh b/ci/build_wheel_cudf.sh
index ae4eb0d5c66..32dd5a7fa62 100755
--- a/ci/build_wheel_cudf.sh
+++ b/ci/build_wheel_cudf.sh
@@ -27,4 +27,6 @@ python -m auditwheel repair \
     -w ${package_dir}/final_dist \
     ${package_dir}/dist/*
 
+./ci/validate_wheel.sh ${package_dir} final_dist
+
 RAPIDS_PY_WHEEL_NAME="cudf_${RAPIDS_PY_CUDA_SUFFIX}" rapids-upload-wheels-to-s3 python ${package_dir}/final_dist
diff --git a/ci/build_wheel_cudf_polars.sh b/ci/build_wheel_cudf_polars.sh
index 79853cdbdb2..38048125247 100755
--- a/ci/build_wheel_cudf_polars.sh
+++ b/ci/build_wheel_cudf_polars.sh
@@ -6,6 +6,7 @@ set -euo pipefail
 package_dir="python/cudf_polars"
 
 ./ci/build_wheel.sh cudf-polars ${package_dir}
+./ci/validate_wheel.sh ${package_dir} dist
 
 RAPIDS_PY_CUDA_SUFFIX="$(rapids-wheel-ctk-name-gen ${RAPIDS_CUDA_VERSION})"
 RAPIDS_PY_WHEEL_NAME="cudf_polars_${RAPIDS_PY_CUDA_SUFFIX}" RAPIDS_PY_WHEEL_PURE="1" rapids-upload-wheels-to-s3 python ${package_dir}/dist
diff --git a/ci/build_wheel_dask_cudf.sh b/ci/build_wheel_dask_cudf.sh
index 00c64afa2ef..b0ae2f23abc 100755
--- a/ci/build_wheel_dask_cudf.sh
+++ b/ci/build_wheel_dask_cudf.sh
@@ -6,6 +6,7 @@ set -euo pipefail
 package_dir="python/dask_cudf"
 
 ./ci/build_wheel.sh dask-cudf ${package_dir}
+./ci/validate_wheel.sh ${package_dir} dist
 
 RAPIDS_PY_CUDA_SUFFIX="$(rapids-wheel-ctk-name-gen ${RAPIDS_CUDA_VERSION})"
 RAPIDS_PY_WHEEL_NAME="dask_cudf_${RAPIDS_PY_CUDA_SUFFIX}" RAPIDS_PY_WHEEL_PURE="1" rapids-upload-wheels-to-s3 python ${package_dir}/dist
diff --git a/ci/build_wheel_libcudf.sh b/ci/build_wheel_libcudf.sh
index aabd3814a24..af49942c8cd 100755
--- a/ci/build_wheel_libcudf.sh
+++ b/ci/build_wheel_libcudf.sh
@@ -37,4 +37,6 @@ python -m auditwheel repair \
     -w ${package_dir}/final_dist \
     ${package_dir}/dist/*
 
+./ci/validate_wheel.sh ${package_dir} final_dist
+
 RAPIDS_PY_WHEEL_NAME="${package_name}_${RAPIDS_PY_CUDA_SUFFIX}" rapids-upload-wheels-to-s3 cpp "${package_dir}/final_dist"
diff --git a/ci/build_wheel_pylibcudf.sh b/ci/build_wheel_pylibcudf.sh
index c4a89f20f5f..5a8f3397714 100755
--- a/ci/build_wheel_pylibcudf.sh
+++ b/ci/build_wheel_pylibcudf.sh
@@ -25,4 +25,6 @@ python -m auditwheel repair \
     -w ${package_dir}/final_dist \
     ${package_dir}/dist/*
 
+./ci/validate_wheel.sh ${package_dir} final_dist
+
 RAPIDS_PY_WHEEL_NAME="pylibcudf_${RAPIDS_PY_CUDA_SUFFIX}" rapids-upload-wheels-to-s3 python ${package_dir}/final_dist
diff --git a/ci/validate_wheel.sh b/ci/validate_wheel.sh
new file mode 100755
index 00000000000..5910a5c59fe
--- /dev/null
+++ b/ci/validate_wheel.sh
@@ -0,0 +1,21 @@
+#!/bin/bash
+# Copyright (c) 2024, NVIDIA CORPORATION.
+
+set -euo pipefail
+
+package_dir=$1
+wheel_dir_relative_path=$2
+
+cd "${package_dir}"
+
+rapids-logger "validate packages with 'pydistcheck'"
+
+pydistcheck \
+    --inspect \
+    "$(echo ${wheel_dir_relative_path}/*.whl)"
+
+rapids-logger "validate packages with 'twine'"
+
+twine check \
+    --strict \
+    "$(echo ${wheel_dir_relative_path}/*.whl)"
diff --git a/python/cudf/pyproject.toml b/python/cudf/pyproject.toml
index ca6dbddfecc..280dd52bb22 100644
--- a/python/cudf/pyproject.toml
+++ b/python/cudf/pyproject.toml
@@ -83,6 +83,14 @@ cudf-pandas-tests = [
 Homepage = "https://github.com/rapidsai/cudf"
 Documentation = "https://docs.rapids.ai/api/cudf/stable/"
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.pytest.ini_options]
 addopts = "--tb=native --strict-config --strict-markers"
 empty_parameter_set_mark = "fail_at_collect"
diff --git a/python/cudf_kafka/pyproject.toml b/python/cudf_kafka/pyproject.toml
index ec0bc0eb22b..b2ea3f06e48 100644
--- a/python/cudf_kafka/pyproject.toml
+++ b/python/cudf_kafka/pyproject.toml
@@ -47,6 +47,14 @@ rapids = ["rmm", "cudf", "dask_cudf"]
 [tool.ruff.lint.per-file-ignores]
 "__init__.py" = ["E402", "F401"]
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.pytest.ini_options]
 addopts = "--tb=native --strict-config --strict-markers"
 empty_parameter_set_mark = "fail_at_collect"
diff --git a/python/cudf_polars/pyproject.toml b/python/cudf_polars/pyproject.toml
index 2e75dff5c9e..32ea142a96c 100644
--- a/python/cudf_polars/pyproject.toml
+++ b/python/cudf_polars/pyproject.toml
@@ -49,6 +49,14 @@ license-files = ["LICENSE"]
 [tool.setuptools.dynamic]
 version = {file = "cudf_polars/VERSION"}
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.pytest.ini_options]
 addopts = "--tb=native --strict-config --strict-markers"
 empty_parameter_set_mark = "fail_at_collect"
diff --git a/python/custreamz/pyproject.toml b/python/custreamz/pyproject.toml
index d3baf3bf4d2..dd67a019c77 100644
--- a/python/custreamz/pyproject.toml
+++ b/python/custreamz/pyproject.toml
@@ -65,6 +65,14 @@ include = [
 ]
 exclude = ["*tests*"]
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.ruff]
 extend = "../../pyproject.toml"
 
diff --git a/python/dask_cudf/pyproject.toml b/python/dask_cudf/pyproject.toml
index c4bfc3054bc..07d9143db36 100644
--- a/python/dask_cudf/pyproject.toml
+++ b/python/dask_cudf/pyproject.toml
@@ -81,6 +81,14 @@ section-order = ["future", "standard-library", "third-party", "dask", "rapids",
 dask = ["dask", "distributed", "dask_cuda"]
 rapids = ["rmm", "cudf"]
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.pytest.ini_options]
 addopts = "--tb=native --strict-config --strict-markers"
 empty_parameter_set_mark = "fail_at_collect"
diff --git a/python/libcudf/pyproject.toml b/python/libcudf/pyproject.toml
index 62726bb0df4..8c650eb2144 100644
--- a/python/libcudf/pyproject.toml
+++ b/python/libcudf/pyproject.toml
@@ -48,6 +48,14 @@ Homepage = "https://github.com/rapidsai/cudf"
 [project.entry-points."cmake.prefix"]
 libcudf = "libcudf"
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 600 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '525M'
+
 [tool.scikit-build]
 build-dir = "build/{wheel_tag}"
 cmake.build-type = "Release"
diff --git a/python/pylibcudf/pyproject.toml b/python/pylibcudf/pyproject.toml
index 83ed95823da..e83db47830c 100644
--- a/python/pylibcudf/pyproject.toml
+++ b/python/pylibcudf/pyproject.toml
@@ -85,6 +85,14 @@ rapids = ["rmm"]
 [tool.ruff.lint.per-file-ignores]
 "__init__.py" = ["E402", "F401"]
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.pytest.ini_options]
 # --import-mode=importlib because two test_json.py exists and tests directory is not a structured module
 addopts = "--tb=native --strict-config --strict-markers --import-mode=importlib"