diff --git a/python/cudf/cudf/io/parquet.py b/python/cudf/cudf/io/parquet.py
index 3e1a4b1f024..6c91a5a8765 100644
--- a/python/cudf/cudf/io/parquet.py
+++ b/python/cudf/cudf/io/parquet.py
@@ -1,14 +1,18 @@
 # Copyright (c) 2019-2023, NVIDIA CORPORATION.
+from __future__ import annotations
 
 import math
+import operator
 import shutil
 import tempfile
 import warnings
 from collections import defaultdict
 from contextlib import ExitStack
-from typing import Dict, List, Optional, Tuple
+from functools import partial, reduce
+from typing import Callable, Dict, List, Optional, Tuple
 from uuid import uuid4
 
+import numpy as np
 import pandas as pd
 from pyarrow import dataset as ds, parquet as pq
 
@@ -481,6 +485,9 @@ def read_parquet(
         path_or_data=filepath_or_buffer, storage_options=storage_options
     )
 
+    # Normalize and validate filters
+    filters = _normalize_filters(filters)
+
     # Use pyarrow dataset to detect/process directory-partitioned
     # data and apply filters. Note that we can only support partitioned
     # data and filtering if the input is a single directory or list of
@@ -501,8 +508,6 @@ def read_parquet(
             categorical_partitions=categorical_partitions,
             dataset_kwargs=dataset_kwargs,
         )
-    elif filters is not None:
-        raise ValueError("cudf cannot apply filters to open file objects.")
     filepath_or_buffer = paths if paths else filepath_or_buffer
 
     filepaths_or_buffers = []
@@ -547,7 +552,8 @@ def read_parquet(
                 "for full CPU-based filtering functionality."
             )
 
-    return _parquet_to_frame(
+    # Convert parquet data to a cudf.DataFrame
+    df = _parquet_to_frame(
         filepaths_or_buffers,
         engine,
         *args,
@@ -561,6 +567,115 @@ def read_parquet(
         **kwargs,
     )
 
+    # Apply filters row-wise (if any are defined), and return
+    return _apply_post_filters(df, filters)
+
+
+def _normalize_filters(filters: list | None) -> List[List[tuple]] | None:
+    # Utility to normalize and validate the `filters`
+    # argument to `read_parquet`
+    if not filters:
+        return None
+
+    msg = (
+        f"filters must be None, or non-empty List[Tuple] "
+        f"or List[List[Tuple]]. Got {filters}"
+    )
+    if not isinstance(filters, list):
+        raise TypeError(msg)
+
+    def _validate_predicate(item):
+        if not isinstance(item, tuple) or len(item) != 3:
+            raise TypeError(
+                f"Predicate must be Tuple[str, str, Any], " f"got {predicate}."
+            )
+
+    filters = filters if isinstance(filters[0], list) else [filters]
+    for conjunction in filters:
+        if not conjunction or not isinstance(conjunction, list):
+            raise TypeError(msg)
+        for predicate in conjunction:
+            _validate_predicate(predicate)
+
+    return filters
+
+
+def _apply_post_filters(
+    df: cudf.DataFrame, filters: List[List[tuple]] | None
+) -> cudf.DataFrame:
+    """Apply DNF filters to an in-memory DataFrame
+
+    Disjunctive normal form (DNF) means that the inner-most
+    tuple describes a single column predicate. These inner
+    predicates are combined with an AND conjunction into a
+    larger predicate. The outer-most list then combines all
+    of the combined filters with an OR disjunction.
+    """
+
+    if not filters:
+        # No filters to apply
+        return df
+
+    def _handle_in(column: cudf.Series, value, *, negate) -> cudf.Series:
+        if not isinstance(value, (list, set, tuple)):
+            raise TypeError(
+                "Value of 'in'/'not in' filter must be a list, set, or tuple."
+            )
+        return ~column.isin(value) if negate else column.isin(value)
+
+    def _handle_is(column: cudf.Series, value, *, negate) -> cudf.Series:
+        if value not in {np.nan, None}:
+            raise TypeError(
+                "Value of 'is'/'is not' filter must be np.nan or None."
+            )
+        return ~column.isna() if negate else column.isna()
+
+    handlers: Dict[str, Callable] = {
+        "==": operator.eq,
+        "!=": operator.ne,
+        "<": operator.lt,
+        "<=": operator.le,
+        ">": operator.gt,
+        ">=": operator.ge,
+        "in": partial(_handle_in, negate=False),
+        "not in": partial(_handle_in, negate=True),
+        "is": partial(_handle_is, negate=False),
+        "is not": partial(_handle_is, negate=True),
+    }
+
+    # Can re-set the index before returning if we filter
+    # out rows from a DataFrame with a default RangeIndex
+    # (to reduce memory usage)
+    reset_index = (
+        isinstance(df.index, cudf.RangeIndex)
+        and df.index.name is None
+        and df.index.start == 0
+        and df.index.step == 1
+    )
+
+    try:
+        selection: cudf.Series = reduce(
+            operator.or_,
+            (
+                reduce(
+                    operator.and_,
+                    (
+                        handlers[op](df[column], value)
+                        for (column, op, value) in expr
+                    ),
+                )
+                for expr in filters
+            ),
+        )
+        if reset_index:
+            return df[selection].reset_index(drop=True)
+        return df[selection]
+    except (KeyError, TypeError):
+        warnings.warn(
+            f"Row-wise filtering failed in read_parquet for {filters}"
+        )
+        return df
+
 
 @_cudf_nvtx_annotate
 def _parquet_to_frame(
diff --git a/python/cudf/cudf/tests/test_parquet.py b/python/cudf/cudf/tests/test_parquet.py
index 0ab5d35f9f8..7aeb2afc2c7 100644
--- a/python/cudf/cudf/tests/test_parquet.py
+++ b/python/cudf/cudf/tests/test_parquet.py
@@ -528,9 +528,7 @@ def test_parquet_read_filtered_multiple_files(tmpdir):
     )
     assert_eq(
         filtered_df,
-        cudf.DataFrame(
-            {"x": [2, 3, 2, 3], "y": list("bbcc")}, index=[2, 3, 2, 3]
-        ),
+        cudf.DataFrame({"x": [2, 2], "y": list("bc")}, index=[2, 2]),
     )
 
 
@@ -541,13 +539,16 @@ def test_parquet_read_filtered_multiple_files(tmpdir):
 @pytest.mark.parametrize(
     "predicate,expected_len",
     [
-        ([[("x", "==", 0)], [("z", "==", 0)]], 4),
-        ([("x", "==", 0), ("z", "==", 0)], 0),
-        ([("x", "==", 0), ("z", "!=", 0)], 2),
+        ([[("x", "==", 0)], [("z", "==", 0)]], 2),
         ([("x", "==", 0), ("z", "==", 0)], 0),
+        ([("x", "==", 0), ("z", "!=", 0)], 1),
         ([("y", "==", "c"), ("x", ">", 8)], 0),
-        ([("y", "==", "c"), ("x", ">=", 5)], 2),
-        ([[("y", "==", "c")], [("x", "<", 3)]], 6),
+        ([("y", "==", "c"), ("x", ">=", 5)], 1),
+        ([[("y", "==", "c")], [("x", "<", 3)]], 5),
+        ([[("x", "not in", (0, 9)), ("z", "not in", (4, 5))]], 6),
+        ([[("y", "==", "c")], [("x", "in", (0, 9)), ("z", "in", (0, 9))]], 4),
+        ([[("x", "==", 0)], [("x", "==", 1)], [("x", "==", 2)]], 3),
+        ([[("x", "==", 0), ("z", "==", 9), ("y", "==", "a")]], 1),
     ],
 )
 def test_parquet_read_filtered_complex_predicate(
@@ -556,7 +557,11 @@ def test_parquet_read_filtered_complex_predicate(
     # Generate data
     fname = tmpdir.join("filtered_complex_predicate.parquet")
     df = pd.DataFrame(
-        {"x": range(10), "y": list("aabbccddee"), "z": reversed(range(10))}
+        {
+            "x": range(10),
+            "y": list("aabbccddee"),
+            "z": reversed(range(10)),
+        }
     )
     df.to_parquet(fname, row_group_size=2)
 
@@ -1954,26 +1959,16 @@ def test_read_parquet_partitioned_filtered(
         assert got.dtypes["c"] == "int"
     assert_eq(expect, got)
 
-    # Filter on non-partitioned column.
-    # Cannot compare to pandas, since the pyarrow
-    # backend will filter by row (and cudf can
-    # only filter by column, for now)
+    # Filter on non-partitioned column
     filters = [("a", "==", 10)]
-    got = cudf.read_parquet(
-        read_path,
-        filters=filters,
-        row_groups=row_groups,
-    )
-    assert len(got) < len(df) and 10 in got["a"]
+    got = cudf.read_parquet(read_path, filters=filters)
+    expect = pd.read_parquet(read_path, filters=filters)
 
     # Filter on both kinds of columns
     filters = [[("a", "==", 10)], [("c", "==", 1)]]
-    got = cudf.read_parquet(
-        read_path,
-        filters=filters,
-        row_groups=row_groups,
-    )
-    assert len(got) < len(df) and (1 in got["c"] and 10 in got["a"])
+    got = cudf.read_parquet(read_path, filters=filters)
+    expect = pd.read_parquet(read_path, filters=filters)
+    assert_eq(expect, got)
 
 
 def test_parquet_writer_chunked_metadata(tmpdir, simple_pdf, simple_gdf):
diff --git a/python/cudf/cudf/utils/ioutils.py b/python/cudf/cudf/utils/ioutils.py
index bf51b360fec..bf9dc226d11 100644
--- a/python/cudf/cudf/utils/ioutils.py
+++ b/python/cudf/cudf/utils/ioutils.py
@@ -147,11 +147,12 @@
     For other URLs (e.g. starting with "s3://", and "gcs://") the key-value
     pairs are forwarded to ``fsspec.open``. Please see ``fsspec`` and
     ``urllib`` for more details.
-filters : list of tuple, list of lists of tuples default None
+filters : list of tuple, list of lists of tuples, default None
     If not None, specifies a filter predicate used to filter out row groups
     using statistics stored for each row group as Parquet metadata. Row groups
-    that do not match the given filter predicate are not read. The
-    predicate is expressed in disjunctive normal form (DNF) like
+    that do not match the given filter predicate are not read. The filters
+    will also be applied to the rows of the in-memory DataFrame after IO.
+    The predicate is expressed in disjunctive normal form (DNF) like
     `[[('x', '=', 0), ...], ...]`. DNF allows arbitrary boolean logical
     combinations of single column predicates. The innermost tuples each
     describe a single column predicate. The list of inner predicates is
diff --git a/python/dask_cudf/dask_cudf/io/parquet.py b/python/dask_cudf/dask_cudf/io/parquet.py
index 67fc7215fc7..bf0f115f310 100644
--- a/python/dask_cudf/dask_cudf/io/parquet.py
+++ b/python/dask_cudf/dask_cudf/io/parquet.py
@@ -20,7 +20,11 @@
 import cudf
 from cudf.core.column import as_column, build_categorical_column
 from cudf.io import write_to_dataset
-from cudf.io.parquet import _default_open_file_options
+from cudf.io.parquet import (
+    _apply_post_filters,
+    _default_open_file_options,
+    _normalize_filters,
+)
 from cudf.utils.dtypes import cudf_dtype_from_pa_type
 from cudf.utils.ioutils import (
     _ROW_GROUP_SIZE_BYTES_DEFAULT,
@@ -69,6 +73,7 @@ def _read_paths(
         fs,
         columns=None,
         row_groups=None,
+        filters=None,
         strings_to_categorical=None,
         partitions=None,
         partitioning=None,
@@ -134,6 +139,10 @@ def _read_paths(
                 else:
                     raise err
 
+        # Apply filters (if any are defined)
+        filters = _normalize_filters(filters)
+        df = _apply_post_filters(df, filters)
+
         if partitions and partition_keys is None:
 
             # Use `HivePartitioning` by default
@@ -183,6 +192,7 @@ def read_partition(
         index,
         categories=(),
         partitions=(),
+        filters=None,
         partitioning=None,
         schema=None,
         open_file_options=None,
@@ -255,6 +265,7 @@ def read_partition(
                             fs,
                             columns=read_columns,
                             row_groups=rgs if rgs else None,
+                            filters=filters,
                             strings_to_categorical=strings_to_cats,
                             partitions=partitions,
                             partitioning=partitioning,
@@ -281,6 +292,7 @@ def read_partition(
                     fs,
                     columns=read_columns,
                     row_groups=rgs if rgs else None,
+                    filters=filters,
                     strings_to_categorical=strings_to_cats,
                     partitions=partitions,
                     partitioning=partitioning,
diff --git a/python/dask_cudf/dask_cudf/io/tests/test_parquet.py b/python/dask_cudf/dask_cudf/io/tests/test_parquet.py
index f5ae9706fde..8e80aad67d1 100644
--- a/python/dask_cudf/dask_cudf/io/tests/test_parquet.py
+++ b/python/dask_cudf/dask_cudf/io/tests/test_parquet.py
@@ -254,6 +254,41 @@ def test_filters(tmpdir):
     assert not len(c)
 
 
+@pytest.mark.parametrize("numeric", [True, False])
+@pytest.mark.parametrize("null", [np.nan, None])
+def test_isna_filters(tmpdir, null, numeric):
+
+    tmp_path = str(tmpdir)
+    df = pd.DataFrame(
+        {
+            "x": range(10),
+            "y": list("aabbccddee"),
+            "i": [0] * 4 + [np.nan] * 2 + [0] * 4,
+            "j": [""] * 4 + [None] * 2 + [""] * 4,
+        }
+    )
+    ddf = dd.from_pandas(df, npartitions=5)
+    assert ddf.npartitions == 5
+    ddf.to_parquet(tmp_path, engine="pyarrow")
+
+    # Test "is"
+    col = "i" if numeric else "j"
+    filters = [(col, "is", null)]
+    out = dask_cudf.read_parquet(
+        tmp_path, filters=filters, split_row_groups=True
+    )
+    assert len(out) == 2
+    assert list(out.x.compute().values) == [4, 5]
+
+    # Test "is not"
+    filters = [(col, "is not", null)]
+    out = dask_cudf.read_parquet(
+        tmp_path, filters=filters, split_row_groups=True
+    )
+    assert len(out) == 8
+    assert list(out.x.compute().values) == [0, 1, 2, 3, 6, 7, 8, 9]
+
+
 def test_filters_at_row_group_level(tmpdir):
 
     tmp_path = str(tmpdir)
@@ -267,7 +302,7 @@ def test_filters_at_row_group_level(tmpdir):
         tmp_path, filters=[("x", "==", 1)], split_row_groups=True
     )
     assert a.npartitions == 1
-    assert (a.shape[0] == 2).compute()
+    assert (a.shape[0] == 1).compute()
 
     ddf.to_parquet(tmp_path, engine="pyarrow", row_group_size=1)