diff --git a/extensions/mongodb-client/runtime/src/main/java/io/quarkus/mongodb/runtime/MongoClientConfig.java b/extensions/mongodb-client/runtime/src/main/java/io/quarkus/mongodb/runtime/MongoClientConfig.java
index acc9c7761fa68..8c631bff5bb38 100644
--- a/extensions/mongodb-client/runtime/src/main/java/io/quarkus/mongodb/runtime/MongoClientConfig.java
+++ b/extensions/mongodb-client/runtime/src/main/java/io/quarkus/mongodb/runtime/MongoClientConfig.java
@@ -179,7 +179,7 @@ public class MongoClientConfig {
     public Optional<String> readConcern;
 
     /**
-     * Configures the read preferences.
+     * Configures the read preference.
      * Supported values are: {@code primary|primaryPreferred|secondary|secondaryPreferred|nearest}
      */
     @ConfigItem
diff --git a/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/MongoEntity.java b/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/MongoEntity.java
index 59902dcc0e69e..7fbc6ff55c917 100644
--- a/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/MongoEntity.java
+++ b/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/MongoEntity.java
@@ -26,4 +26,10 @@
      * The name of the MongoDB client (if not set the default client will be used).
      */
     String clientName() default "";
+
+    /**
+     * Configures the read preference for the collection of this entity.
+     * Supported values are: {@code primary|primaryPreferred|secondary|secondaryPreferred|nearest}
+     */
+    String readPreference() default "";
 }
diff --git a/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/reactive/runtime/ReactiveMongoOperations.java b/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/reactive/runtime/ReactiveMongoOperations.java
index 966bdac9aeeca..955af2d443679 100644
--- a/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/reactive/runtime/ReactiveMongoOperations.java
+++ b/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/reactive/runtime/ReactiveMongoOperations.java
@@ -23,6 +23,7 @@
 import org.bson.codecs.EncoderContext;
 import org.jboss.logging.Logger;
 
+import com.mongodb.ReadPreference;
 import com.mongodb.client.model.InsertOneModel;
 import com.mongodb.client.model.ReplaceOneModel;
 import com.mongodb.client.model.ReplaceOptions;
@@ -218,8 +219,20 @@ public Uni<Void> delete(Object entity) {
     public ReactiveMongoCollection mongoCollection(Class<?> entityClass) {
         MongoEntity mongoEntity = entityClass.getAnnotation(MongoEntity.class);
         ReactiveMongoDatabase database = mongoDatabase(mongoEntity);
-        if (mongoEntity != null && !mongoEntity.collection().isEmpty()) {
-            return database.getCollection(mongoEntity.collection(), entityClass);
+        if (mongoEntity != null) {
+            ReactiveMongoCollection collection = mongoEntity.collection().isEmpty()
+                    ? database.getCollection(entityClass.getSimpleName(), entityClass)
+                    : database.getCollection(mongoEntity.collection(), entityClass);
+            if (!mongoEntity.readPreference().isEmpty()) {
+                try {
+                    collection = collection.withReadPreference(ReadPreference.valueOf(mongoEntity.readPreference()));
+                } catch (IllegalArgumentException iae) {
+                    throw new IllegalArgumentException("Illegal read preference " + mongoEntity.readPreference()
+                            + " configured in the @MongoEntity annotation of " + entityClass.getName() + "."
+                            + " Supported values are primary|primaryPreferred|secondary|secondaryPreferred|nearest");
+                }
+            }
+            return collection;
         }
         return database.getCollection(entityClass.getSimpleName(), entityClass);
     }
diff --git a/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/runtime/MongoOperations.java b/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/runtime/MongoOperations.java
index f2179661055eb..6f6343c591484 100644
--- a/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/runtime/MongoOperations.java
+++ b/extensions/panache/mongodb-panache-common/runtime/src/main/java/io/quarkus/mongodb/panache/common/runtime/MongoOperations.java
@@ -24,6 +24,7 @@
 import org.bson.codecs.EncoderContext;
 import org.jboss.logging.Logger;
 
+import com.mongodb.ReadPreference;
 import com.mongodb.client.ClientSession;
 import com.mongodb.client.MongoClient;
 import com.mongodb.client.MongoCollection;
@@ -190,8 +191,20 @@ public void delete(Object entity) {
     public MongoCollection mongoCollection(Class<?> entityClass) {
         MongoEntity mongoEntity = entityClass.getAnnotation(MongoEntity.class);
         MongoDatabase database = mongoDatabase(mongoEntity);
-        if (mongoEntity != null && !mongoEntity.collection().isEmpty()) {
-            return database.getCollection(mongoEntity.collection(), entityClass);
+        if (mongoEntity != null) {
+            MongoCollection collection = mongoEntity.collection().isEmpty()
+                    ? database.getCollection(entityClass.getSimpleName(), entityClass)
+                    : database.getCollection(mongoEntity.collection(), entityClass);
+            if (!mongoEntity.readPreference().isEmpty()) {
+                try {
+                    collection = collection.withReadPreference(ReadPreference.valueOf(mongoEntity.readPreference()));
+                } catch (IllegalArgumentException iae) {
+                    throw new IllegalArgumentException("Illegal read preference " + mongoEntity.readPreference()
+                            + " configured in the @MongoEntity annotation of " + entityClass.getName() + "."
+                            + " Supported values are primary|primaryPreferred|secondary|secondaryPreferred|nearest");
+                }
+            }
+            return collection;
         }
         return database.getCollection(entityClass.getSimpleName(), entityClass);
     }
diff --git a/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/book/BookEntity.kt b/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/book/BookEntity.kt
index 2ea85aaf953ab..2956c57ed2385 100644
--- a/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/book/BookEntity.kt
+++ b/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/book/BookEntity.kt
@@ -11,7 +11,7 @@ import org.bson.codecs.pojo.annotations.BsonProperty
 import org.bson.types.ObjectId
 import java.time.LocalDate
 
-@MongoEntity(collection = "TheBookEntity", clientName = "cl2")
+@MongoEntity(collection = "TheBookEntity", clientName = "cl2", readPreference = "primary")
 class BookEntity : PanacheMongoEntity() {
     companion object : PanacheMongoCompanion<BookEntity> {
         override fun findById(id: ObjectId): BookEntity {
diff --git a/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.kt b/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.kt
index 7ed1c17287348..728875fe20dfd 100644
--- a/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.kt
+++ b/integration-tests/mongodb-panache-kotlin/src/main/kotlin/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.kt
@@ -11,7 +11,7 @@ import org.bson.codecs.pojo.annotations.BsonProperty
 import java.time.LocalDate
 import java.util.ArrayList
 
-@MongoEntity(collection = "TheBookEntity", clientName = "cl2")
+@MongoEntity(collection = "TheBookEntity", clientName = "cl2", readPreference = "primary")
 class ReactiveBookEntity : ReactivePanacheMongoEntity() {
     companion object : ReactivePanacheMongoCompanion<ReactiveBookEntity>
 
diff --git a/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/book/BookEntity.java b/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/book/BookEntity.java
index 6da808cd876f4..a6ff655ef97b7 100644
--- a/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/book/BookEntity.java
+++ b/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/book/BookEntity.java
@@ -13,7 +13,7 @@
 import io.quarkus.mongodb.panache.PanacheMongoEntity;
 import io.quarkus.mongodb.panache.common.MongoEntity;
 
-@MongoEntity(collection = "TheBookEntity", clientName = "cl2")
+@MongoEntity(collection = "TheBookEntity", clientName = "cl2", readPreference = "primary")
 public class BookEntity extends PanacheMongoEntity {
     @BsonProperty("bookTitle")
     private String title;
diff --git a/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.java b/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.java
index 2a7437d1db7e3..2c844dbcc9550 100644
--- a/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.java
+++ b/integration-tests/mongodb-panache/src/main/java/io/quarkus/it/mongodb/panache/reactive/book/ReactiveBookEntity.java
@@ -14,7 +14,7 @@
 import io.quarkus.mongodb.panache.common.MongoEntity;
 import io.quarkus.mongodb.panache.reactive.ReactivePanacheMongoEntity;
 
-@MongoEntity(collection = "TheBookEntity", clientName = "cl2")
+@MongoEntity(collection = "TheBookEntity", clientName = "cl2", readPreference = "primary")
 public class ReactiveBookEntity extends ReactivePanacheMongoEntity {
     @BsonProperty("bookTitle")
     private String title;