diff --git a/extensions/panache/hibernate-orm-panache-common/runtime/src/main/java/io/quarkus/hibernate/orm/panache/common/runtime/CommonPanacheQueryImpl.java b/extensions/panache/hibernate-orm-panache-common/runtime/src/main/java/io/quarkus/hibernate/orm/panache/common/runtime/CommonPanacheQueryImpl.java
index 70bfb1a803373..e06891dcb7e20 100644
--- a/extensions/panache/hibernate-orm-panache-common/runtime/src/main/java/io/quarkus/hibernate/orm/panache/common/runtime/CommonPanacheQueryImpl.java
+++ b/extensions/panache/hibernate-orm-panache-common/runtime/src/main/java/io/quarkus/hibernate/orm/panache/common/runtime/CommonPanacheQueryImpl.java
@@ -54,6 +54,8 @@ public void close() {
 
     private Map<String, Map<String, Object>> filters;
 
+    private final String lineSeparator = System.getProperty("line.separator");;
+
     public CommonPanacheQueryImpl(EntityManager em, String query, String orderBy, Object paramsArrayOrMap) {
         this.em = em;
         this.query = query;
@@ -82,7 +84,7 @@ public <T> CommonPanacheQueryImpl<T> project(Class<T> type) {
             throw new PanacheQueryException("Unable to perform a projection on a named query");
         }
 
-        String lowerCasedTrimmedQuery = query.trim().toLowerCase();
+        String lowerCasedTrimmedQuery = query.trim().replace(lineSeparator, " ").toLowerCase();
         if (lowerCasedTrimmedQuery.startsWith("select new ")) {
             throw new PanacheQueryException("Unable to perform a projection on a 'select new' query: " + query);
         }
@@ -93,7 +95,7 @@ public <T> CommonPanacheQueryImpl<T> project(Class<T> type) {
         // New query: SELECT new org.acme.ProjectionClass(e.field1, e.field2) from EntityClass e
         if (lowerCasedTrimmedQuery.startsWith("select ")) {
             int endSelect = lowerCasedTrimmedQuery.indexOf(" from ");
-            String trimmedQuery = query.trim();
+            String trimmedQuery = query.trim().replace(lineSeparator, " ");
             // 7 is the length of "select "
             String selectClause = trimmedQuery.substring(7, endSelect).trim();
             String from = trimmedQuery.substring(endSelect);
diff --git a/integration-tests/hibernate-orm-panache/src/main/java/io/quarkus/it/panache/TestEndpoint.java b/integration-tests/hibernate-orm-panache/src/main/java/io/quarkus/it/panache/TestEndpoint.java
index 363fd589281d4..e316d5f99c67f 100644
--- a/integration-tests/hibernate-orm-panache/src/main/java/io/quarkus/it/panache/TestEndpoint.java
+++ b/integration-tests/hibernate-orm-panache/src/main/java/io/quarkus/it/panache/TestEndpoint.java
@@ -1188,6 +1188,11 @@ public String testProjection() {
         person = Person.find("name = ?1", "2").project(PersonName.class).firstResult();
         Assertions.assertEquals("2", person.name);
 
+        person = Person.find("select uniqueName, name\nfrom io.quarkus.it.panache.Person\nwhere name = ?1", "2")
+                .project(PersonName.class)
+                .firstResult();
+        Assertions.assertEquals("2", person.name);
+
         person = Person.find("name = :name", Parameters.with("name", "2")).project(PersonName.class).firstResult();
         Assertions.assertEquals("2", person.name);