diff --git a/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Annotations.java b/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Annotations.java
index 66d43bf7538d4..d52ed97e0f1d0 100644
--- a/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Annotations.java
+++ b/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Annotations.java
@@ -105,6 +105,22 @@ public static Set<AnnotationInstance> getAnnotations(Kind kind, DotName name, Co
         return ret;
     }
 
+    /**
+     *
+     * @param beanDeployment
+     * @param method
+     * @return collection of annotations present on all parameters of given method
+     */
+    public static Set<AnnotationInstance> getParameterAnnotations(BeanDeployment beanDeployment, MethodInfo method) {
+        Set<AnnotationInstance> annotations = new HashSet<>();
+        for (AnnotationInstance annotation : beanDeployment.getAnnotations(method)) {
+            if (Kind.METHOD_PARAMETER == annotation.target().kind()) {
+                annotations.add(annotation);
+            }
+        }
+        return annotations;
+    }
+
     /**
      * 
      * @param beanDeployment
diff --git a/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/BeanDeployment.java b/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/BeanDeployment.java
index 786837e2c0b61..593178f895023 100644
--- a/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/BeanDeployment.java
+++ b/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/BeanDeployment.java
@@ -613,6 +613,10 @@ public AnnotationInstance getAnnotation(AnnotationTarget target, DotName name) {
         return annotationStore.getAnnotation(target, name);
     }
 
+    public boolean hasAnnotation(AnnotationTarget target, DotName name) {
+        return annotationStore.hasAnnotation(target, name);
+    }
+
     Map<ScopeInfo, Function<MethodCreator, ResultHandle>> getCustomContexts() {
         return customContexts;
     }
diff --git a/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Injection.java b/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Injection.java
index 58867caadfaa9..dd3c68336b164 100644
--- a/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Injection.java
+++ b/independent-projects/arc/processor/src/main/java/io/quarkus/arc/processor/Injection.java
@@ -40,6 +40,7 @@ static List<Injection> forBean(AnnotationTarget beanTarget, BeanInfo declaringBe
         if (Kind.CLASS.equals(beanTarget.kind())) {
             List<Injection> injections = new ArrayList<>();
             forClassBean(beanTarget.asClass(), beanTarget.asClass(), beanDeployment, injections, transformer, false);
+
             Set<AnnotationTarget> injectConstructors = injections.stream().filter(Injection::isConstructor)
                     .map(Injection::getTarget).collect(Collectors.toSet());
             if (injectConstructors.size() > 1) {
@@ -47,6 +48,41 @@ static List<Injection> forBean(AnnotationTarget beanTarget, BeanInfo declaringBe
                         "Multiple @Inject constructors found on " + beanTarget.asClass().name() + ":\n"
                                 + injectConstructors.stream().map(Object::toString).collect(Collectors.joining("\n")));
             }
+
+            Set<MethodInfo> initializerMethods = injections.stream()
+                    .filter(it -> it.isMethod() && !it.isConstructor())
+                    .map(Injection::getTarget)
+                    .map(AnnotationTarget::asMethod)
+                    .collect(Collectors.toSet());
+            for (MethodInfo initializerMethod : initializerMethods) {
+                if (beanDeployment.hasAnnotation(initializerMethod, DotNames.PRODUCES)) {
+                    throw new DefinitionException("Initializer method must not be marked @Produces "
+                            + "(alternatively, producer method must not be marked @Inject): "
+                            + beanTarget.asClass() + "." + initializerMethod.name());
+                }
+
+                if (Annotations.contains(Annotations.getParameterAnnotations(beanDeployment, initializerMethod),
+                        DotNames.DISPOSES)) {
+                    throw new DefinitionException("Initializer method must not have a parameter marked @Disposes "
+                            + "(alternatively, disposer method must not be marked @Inject): "
+                            + beanTarget.asClass() + "." + initializerMethod.name());
+                }
+
+                if (Annotations.contains(Annotations.getParameterAnnotations(beanDeployment, initializerMethod),
+                        DotNames.OBSERVES)) {
+                    throw new DefinitionException("Initializer method must not have a parameter marked @Observes "
+                            + "(alternatively, observer method must not be marked @Inject): "
+                            + beanTarget.asClass() + "." + initializerMethod.name());
+                }
+
+                if (Annotations.contains(Annotations.getParameterAnnotations(beanDeployment, initializerMethod),
+                        DotNames.OBSERVES_ASYNC)) {
+                    throw new DefinitionException("Initializer method must not have a parameter marked @ObservesAsync "
+                            + "(alternatively, async observer method must not be marked @Inject): "
+                            + beanTarget.asClass() + "." + initializerMethod.name());
+                }
+            }
+
             return injections;
         } else if (Kind.METHOD.equals(beanTarget.kind())) {
             if (beanTarget.asMethod().parameters().isEmpty()) {
diff --git a/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedAsyncObserverTest.java b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedAsyncObserverTest.java
new file mode 100644
index 0000000000000..b73ebc907d69f
--- /dev/null
+++ b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedAsyncObserverTest.java
@@ -0,0 +1,31 @@
+package io.quarkus.arc.test.validation;
+
+import static org.junit.jupiter.api.Assertions.assertNotNull;
+import static org.junit.jupiter.api.Assertions.assertTrue;
+
+import io.quarkus.arc.test.ArcTestContainer;
+import javax.enterprise.context.ApplicationScoped;
+import javax.enterprise.event.ObservesAsync;
+import javax.enterprise.inject.spi.DefinitionException;
+import javax.inject.Inject;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+public class InitializerMethodMarkedAsyncObserverTest {
+    @RegisterExtension
+    public ArcTestContainer container = ArcTestContainer.builder().beanClasses(MyBean.class).shouldFail().build();
+
+    @Test
+    public void testFailure() {
+        Throwable error = container.getFailure();
+        assertNotNull(error);
+        assertTrue(error instanceof DefinitionException);
+    }
+
+    @ApplicationScoped
+    static class MyBean {
+        @Inject
+        void observeAsync(@ObservesAsync Object ignored) {
+        }
+    }
+}
diff --git a/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedDisposerTest.java b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedDisposerTest.java
new file mode 100644
index 0000000000000..0094546f3dc12
--- /dev/null
+++ b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedDisposerTest.java
@@ -0,0 +1,41 @@
+package io.quarkus.arc.test.validation;
+
+import static org.junit.jupiter.api.Assertions.assertNotNull;
+import static org.junit.jupiter.api.Assertions.assertTrue;
+
+import io.quarkus.arc.test.ArcTestContainer;
+import javax.enterprise.context.ApplicationScoped;
+import javax.enterprise.inject.Disposes;
+import javax.enterprise.inject.Produces;
+import javax.enterprise.inject.spi.DefinitionException;
+import javax.inject.Inject;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+public class InitializerMethodMarkedDisposerTest {
+    @RegisterExtension
+    public ArcTestContainer container = ArcTestContainer.builder().beanClasses(Producers.class).shouldFail().build();
+
+    @Test
+    public void testFailure() {
+        Throwable error = container.getFailure();
+        assertNotNull(error);
+        assertTrue(error instanceof DefinitionException);
+    }
+
+    @ApplicationScoped
+    static class Producers {
+        @Produces
+        @ApplicationScoped
+        MyBean produce() {
+            return new MyBean();
+        }
+
+        @Inject
+        void dispose(@Disposes MyBean bean) {
+        }
+    }
+
+    static class MyBean {
+    }
+}
diff --git a/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedObserverTest.java b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedObserverTest.java
new file mode 100644
index 0000000000000..7b24ff4c97114
--- /dev/null
+++ b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedObserverTest.java
@@ -0,0 +1,31 @@
+package io.quarkus.arc.test.validation;
+
+import static org.junit.jupiter.api.Assertions.assertNotNull;
+import static org.junit.jupiter.api.Assertions.assertTrue;
+
+import io.quarkus.arc.test.ArcTestContainer;
+import javax.enterprise.context.ApplicationScoped;
+import javax.enterprise.event.Observes;
+import javax.enterprise.inject.spi.DefinitionException;
+import javax.inject.Inject;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+public class InitializerMethodMarkedObserverTest {
+    @RegisterExtension
+    public ArcTestContainer container = ArcTestContainer.builder().beanClasses(MyBean.class).shouldFail().build();
+
+    @Test
+    public void testFailure() {
+        Throwable error = container.getFailure();
+        assertNotNull(error);
+        assertTrue(error instanceof DefinitionException);
+    }
+
+    @ApplicationScoped
+    static class MyBean {
+        @Inject
+        void observe(@Observes Object ignored) {
+        }
+    }
+}
diff --git a/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedProducerTest.java b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedProducerTest.java
new file mode 100644
index 0000000000000..188393f30ab87
--- /dev/null
+++ b/independent-projects/arc/tests/src/test/java/io/quarkus/arc/test/validation/InitializerMethodMarkedProducerTest.java
@@ -0,0 +1,37 @@
+package io.quarkus.arc.test.validation;
+
+import static org.junit.jupiter.api.Assertions.assertNotNull;
+import static org.junit.jupiter.api.Assertions.assertTrue;
+
+import io.quarkus.arc.test.ArcTestContainer;
+import javax.enterprise.context.ApplicationScoped;
+import javax.enterprise.inject.Produces;
+import javax.enterprise.inject.spi.DefinitionException;
+import javax.inject.Inject;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+public class InitializerMethodMarkedProducerTest {
+    @RegisterExtension
+    public ArcTestContainer container = ArcTestContainer.builder().beanClasses(Producers.class).shouldFail().build();
+
+    @Test
+    public void testFailure() {
+        Throwable error = container.getFailure();
+        assertNotNull(error);
+        assertTrue(error instanceof DefinitionException);
+    }
+
+    @ApplicationScoped
+    static class Producers {
+        @Inject
+        @Produces
+        @ApplicationScoped
+        MyBean produce() {
+            return new MyBean();
+        }
+    }
+
+    static class MyBean {
+    }
+}