diff --git a/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java b/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java
index e5a44529859e7..815441cbad750 100644
--- a/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java
+++ b/extensions/resteasy-reactive/jaxrs-client-reactive/deployment/src/main/java/io/quarkus/jaxrs/client/reactive/deployment/JaxrsClientReactiveProcessor.java
@@ -6,7 +6,6 @@
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.CONSUMES;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.OBJECT;
 import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.UNI;
-import static org.jboss.resteasy.reactive.common.processor.ResteasyReactiveDotNames.WEB_APPLICATION_EXCEPTION;
 
 import java.io.Closeable;
 import java.io.File;
@@ -17,7 +16,7 @@
 import java.util.Collections;
 import java.util.Comparator;
 import java.util.HashMap;
-import java.util.HashSet;
+import java.util.LinkedHashSet;
 import java.util.List;
 import java.util.Map;
 import java.util.Optional;
@@ -1292,14 +1291,16 @@ private void handleReturn(ClassInfo restClientInterface, String defaultMediaType
         String mediaTypeValue = defaultMediaType;
 
         // if a JAXRS method throws an exception, unwrap the ProcessingException and throw the exception instead
-        // Similarly with WebApplicationException
+        // Similarly with RuntimeException's
         TryBlock tryBlock = methodCreator.tryBlock();
 
         List<Type> exceptionTypes = jandexMethod.exceptions();
-        Set<DotName> exceptions = new HashSet<>();
-        exceptions.add(WEB_APPLICATION_EXCEPTION);
+        Set<String> exceptions = new LinkedHashSet<>();
         for (Type exceptionType : exceptionTypes) {
-            exceptions.add(exceptionType.name());
+            exceptions.add(exceptionType.name().toString());
+        }
+        if (!exceptions.contains(Exception.class.getName()) && !exceptions.contains(Throwable.class.getName())) {
+            exceptions.add(RuntimeException.class.getName());
         }
 
         CatchBlockCreator catchBlock = tryBlock.addCatch(ProcessingException.class);
@@ -1307,8 +1308,8 @@ private void handleReturn(ClassInfo restClientInterface, String defaultMediaType
         ResultHandle cause = catchBlock.invokeVirtualMethod(
                 MethodDescriptor.ofMethod(Throwable.class, "getCause", Throwable.class),
                 caughtException);
-        for (DotName exception : exceptions) {
-            catchBlock.ifTrue(catchBlock.instanceOf(cause, exception.toString()))
+        for (String exception : exceptions) {
+            catchBlock.ifTrue(catchBlock.instanceOf(cause, exception))
                     .trueBranch().throwException(cause);
         }
 
diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientResponseFilter.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientResponseFilter.java
index 56c123b4e17a2..61b8d685cfd6f 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientResponseFilter.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientResponseFilter.java
@@ -3,7 +3,6 @@
 import java.io.IOException;
 import java.util.List;
 
-import javax.ws.rs.ProcessingException;
 import javax.ws.rs.client.ClientRequestContext;
 import javax.ws.rs.client.ClientResponseContext;
 import javax.ws.rs.client.ClientResponseFilter;
@@ -12,6 +11,7 @@
 import org.jboss.resteasy.reactive.client.handlers.ClientResponseCompleteRestHandler;
 import org.jboss.resteasy.reactive.client.impl.ClientRequestContextImpl;
 import org.jboss.resteasy.reactive.client.impl.RestClientRequestContext;
+import org.jboss.resteasy.reactive.common.core.UnwrappableException;
 import org.jboss.resteasy.reactive.common.jaxrs.ResponseImpl;
 
 public class MicroProfileRestClientResponseFilter implements ClientResponseFilter {
@@ -35,7 +35,7 @@ public void filter(ClientRequestContext requestContext, ClientResponseContext re
                 ResponseImpl response = ClientResponseCompleteRestHandler.mapToResponse(restClientContext, false);
                 Throwable throwable = exceptionMapper.toThrowable(response);
                 if (throwable != null) {
-                    throw new ProcessingException(throwable);
+                    throw new UnwrappableException(throwable);
                 }
             }
         }
diff --git a/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/AbstractResteasyReactiveContext.java b/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/AbstractResteasyReactiveContext.java
index 5af64f58d38d4..65ab465b7288d 100644
--- a/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/AbstractResteasyReactiveContext.java
+++ b/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/AbstractResteasyReactiveContext.java
@@ -293,22 +293,30 @@ public H[] getHandlers() {
      */
     public void handleException(Throwable t) {
         if (handlers == abortHandlerChain) {
-            handleUnrecoverableError(t);
+            handleUnrecoverableError(unwrapException(t));
         } else {
-            this.throwable = t;
+            this.throwable = unwrapException(t);
             restart(abortHandlerChain);
         }
     }
 
     public void handleException(Throwable t, boolean keepSameTarget) {
         if (handlers == abortHandlerChain) {
-            handleUnrecoverableError(t);
+            handleUnrecoverableError(unwrapException(t));
         } else {
-            this.throwable = t;
+            this.throwable = unwrapException(t);
             restart(abortHandlerChain, keepSameTarget);
         }
     }
 
+    private Throwable unwrapException(Throwable t) {
+        if (t instanceof UnwrappableException) {
+            return t.getCause();
+        }
+
+        return t;
+    }
+
     protected abstract void handleUnrecoverableError(Throwable throwable);
 
     public Object getProperty(String name) {
diff --git a/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/UnwrappableException.java b/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/UnwrappableException.java
new file mode 100644
index 0000000000000..450c73f39c024
--- /dev/null
+++ b/independent-projects/resteasy-reactive/common/runtime/src/main/java/org/jboss/resteasy/reactive/common/core/UnwrappableException.java
@@ -0,0 +1,9 @@
+package org.jboss.resteasy.reactive.common.core;
+
+import javax.ws.rs.ProcessingException;
+
+public class UnwrappableException extends ProcessingException {
+    public UnwrappableException(Throwable cause) {
+        super(cause);
+    }
+}
\ No newline at end of file