diff --git a/extensions/resteasy-classic/rest-client-config/runtime/src/main/java/io/quarkus/restclient/config/RestClientConfig.java b/extensions/resteasy-classic/rest-client-config/runtime/src/main/java/io/quarkus/restclient/config/RestClientConfig.java
index fafe00369eb93..b42bbc23055cb 100644
--- a/extensions/resteasy-classic/rest-client-config/runtime/src/main/java/io/quarkus/restclient/config/RestClientConfig.java
+++ b/extensions/resteasy-classic/rest-client-config/runtime/src/main/java/io/quarkus/restclient/config/RestClientConfig.java
@@ -1,5 +1,7 @@
 package io.quarkus.restclient.config;
 
+import java.util.Collections;
+import java.util.Map;
 import java.util.Optional;
 
 import org.eclipse.microprofile.config.Config;
@@ -8,6 +10,7 @@
 
 import io.quarkus.runtime.annotations.ConfigGroup;
 import io.quarkus.runtime.annotations.ConfigItem;
+import io.smallrye.config.SmallRyeConfig;
 
 @ConfigGroup
 public class RestClientConfig {
@@ -35,6 +38,7 @@ public class RestClientConfig {
         EMPTY.connectionTTL = Optional.empty();
         EMPTY.connectionPoolSize = Optional.empty();
         EMPTY.maxRedirects = Optional.empty();
+        EMPTY.headers = Collections.emptyMap();
     }
 
     /**
@@ -161,6 +165,12 @@ public class RestClientConfig {
     @ConfigItem
     public Optional<Integer> maxRedirects;
 
+    /**
+     * The HTTP headers that should be applied to all requests of the rest client.
+     */
+    @ConfigItem
+    public Map<String, String> headers;
+
     public static RestClientConfig load(String configKey) {
         final RestClientConfig instance = new RestClientConfig();
 
@@ -183,6 +193,7 @@ public static RestClientConfig load(String configKey) {
         instance.connectionTTL = getConfigValue(configKey, "connection-ttl", Integer.class);
         instance.connectionPoolSize = getConfigValue(configKey, "connection-pool-size", Integer.class);
         instance.maxRedirects = getConfigValue(configKey, "max-redirects", Integer.class);
+        instance.headers = getConfigValues(configKey, "headers", String.class, String.class);
 
         return instance;
     }
@@ -209,6 +220,7 @@ public static RestClientConfig load(Class<?> interfaceClass) {
         instance.connectionTTL = getConfigValue(interfaceClass, "connection-ttl", Integer.class);
         instance.connectionPoolSize = getConfigValue(interfaceClass, "connection-pool-size", Integer.class);
         instance.maxRedirects = getConfigValue(interfaceClass, "max-redirects", Integer.class);
+        instance.headers = getConfigValues(interfaceClass, "headers", String.class, String.class);
 
         return instance;
     }
@@ -237,6 +249,33 @@ private static <T> Optional<T> getConfigValue(Class<?> clientInterface, String f
         return optional;
     }
 
+    private static <K, V> Map<K, V> getConfigValues(String configKey, String fieldName, Class<K> keyType, Class<V> valueType) {
+        final SmallRyeConfig config = (SmallRyeConfig) ConfigProvider.getConfig();
+        Optional<Map<K, V>> optional = config.getOptionalValues(composePropertyKey(configKey, fieldName), keyType, valueType);
+        if (optional.isEmpty()) { // try to find property with quoted configKey
+            optional = config.getOptionalValues(composePropertyKey('"' + configKey + '"', fieldName), keyType, valueType);
+        }
+        return optional.isPresent() ? optional.get() : Collections.emptyMap();
+    }
+
+    private static <K, V> Map<K, V> getConfigValues(Class<?> clientInterface, String fieldName, Class<K> keyType,
+            Class<V> valueType) {
+        final SmallRyeConfig config = (SmallRyeConfig) ConfigProvider.getConfig();
+        // first try interface full name
+        Optional<Map<K, V>> optional = config.getOptionalValues(
+                composePropertyKey('"' + clientInterface.getName() + '"', fieldName),
+                keyType, valueType);
+        if (optional.isEmpty()) { // then interface simple name
+            optional = config.getOptionalValues(composePropertyKey(clientInterface.getSimpleName(), fieldName), keyType,
+                    valueType);
+        }
+        if (optional.isEmpty()) { // lastly quoted interface simple name
+            optional = config.getOptionalValues(composePropertyKey('"' + clientInterface.getSimpleName() + '"', fieldName),
+                    keyType, valueType);
+        }
+        return optional.isPresent() ? optional.get() : Collections.emptyMap();
+    }
+
     private static String composePropertyKey(String key, String fieldName) {
         return Constants.QUARKUS_CONFIG_PREFIX + key + "." + fieldName;
     }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ClassNameScopeOverrideTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ClassNameScopeOverrideTest.java
index faf741481caae..d099c885ba2cd 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ClassNameScopeOverrideTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ClassNameScopeOverrideTest.java
@@ -36,6 +36,6 @@ void shouldHaveDependentScope() {
 
     @Test
     void shouldConnect() {
-        assertThat(client.echo("Bob")).isEqualTo("hello, Bob");
+        assertThat(client.echo("Bob")).isEqualTo("hello, Bob!!!");
     }
 }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ConfigurationTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ConfigurationTest.java
index d2bc39d87cdb1..3b196210f91b0 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ConfigurationTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ConfigurationTest.java
@@ -1,6 +1,7 @@
 package io.quarkus.rest.client.reactive;
 
 import static org.assertj.core.api.Assertions.assertThat;
+import static org.assertj.core.api.Assertions.entry;
 
 import java.util.Set;
 
@@ -44,7 +45,7 @@ void shouldHaveSingletonScope() {
 
     @Test
     void clientShouldRespond() {
-        assertThat(client.echo("world!")).isEqualTo("hello, world!");
+        assertThat(client.echo("world")).isEqualTo("hi, world!");
     }
 
     @Test
@@ -61,10 +62,12 @@ void configurationShouldBeLoaded() {
         verifyClientConfig(clientConfig, true);
         assertThat(clientConfig.proxyAddress.isPresent()).isTrue();
         assertThat(clientConfig.proxyAddress.get()).isEqualTo("localhost:8080");
+        assertThat(clientConfig.headers).containsOnly(entry("user-agent", "MP REST Client"), entry("foo", "bar"));
 
         clientConfig = RestClientConfig.load("quoted-client-prefix");
         assertThat(clientConfig.url.isPresent()).isTrue();
         assertThat(clientConfig.url.get()).endsWith("/hello");
+        assertThat(clientConfig.headers).containsOnly(entry("foo", "bar"));
 
         clientConfig = RestClientConfig.load("mp-client-prefix");
         verifyClientConfig(clientConfig, false);
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/HelloClientWithBaseUri.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/HelloClientWithBaseUri.java
index f9162df8add58..1a947b9261921 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/HelloClientWithBaseUri.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/HelloClientWithBaseUri.java
@@ -11,9 +11,12 @@
 import javax.ws.rs.client.ClientResponseFilter;
 import javax.ws.rs.core.MediaType;
 
+import org.eclipse.microprofile.rest.client.annotation.ClientHeaderParam;
 import org.eclipse.microprofile.rest.client.inject.RegisterRestClient;
 
 @RegisterRestClient(baseUri = "http://localhost:8081/invalid-endpoint") // should be overridden by application.properties
+@ClientHeaderParam(name = "suffix", value = "!!!") // should be overridden by application properties
+@ClientHeaderParam(name = "comma", value = ",")
 public interface HelloClientWithBaseUri {
     @POST
     @Consumes(MediaType.TEXT_PLAIN)
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/MpClassNameScopeOverrideTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/MpClassNameScopeOverrideTest.java
index 013e31fe1bab1..550d8f8b725da 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/MpClassNameScopeOverrideTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/MpClassNameScopeOverrideTest.java
@@ -36,6 +36,6 @@ void shouldHaveDependentScope() {
 
     @Test
     void shouldConnect() {
-        assertThat(client.echo("Bob")).isEqualTo("hello, Bob");
+        assertThat(client.echo("Bob")).isEqualTo("hello, Bob!!!");
     }
 }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ShortNameScopeOverrideTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ShortNameScopeOverrideTest.java
index ce127912ea66c..5125d0e1a431f 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ShortNameScopeOverrideTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/ShortNameScopeOverrideTest.java
@@ -36,6 +36,6 @@ void shouldHaveDependentScope() {
 
     @Test
     void shouldConnect() {
-        assertThat(client.echo("Bob")).isEqualTo("hello, Bob");
+        assertThat(client.echo("Bob")).isEqualTo("hello, Bob!!!");
     }
 }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/configuration/EchoResource.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/configuration/EchoResource.java
index 2fe910d4973b8..b023965ff7cab 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/configuration/EchoResource.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/configuration/EchoResource.java
@@ -5,6 +5,7 @@
 import javax.ws.rs.Path;
 import javax.ws.rs.Produces;
 import javax.ws.rs.core.Context;
+import javax.ws.rs.core.HttpHeaders;
 import javax.ws.rs.core.MediaType;
 import javax.ws.rs.core.Request;
 
@@ -13,7 +14,11 @@
 @Consumes(MediaType.TEXT_PLAIN)
 public class EchoResource {
     @POST
-    public String echo(String name, @Context Request request) {
-        return "hello, " + name;
+    public String echo(String name, @Context Request request, @Context HttpHeaders httpHeaders) {
+        var message = httpHeaders.getHeaderString("message");
+        var comma = httpHeaders.getHeaderString("comma");
+        var suffix = httpHeaders.getHeaderString("suffix");
+        return (message != null ? message : "hello") + (comma != null ? comma : "_") + " " + name
+                + (suffix != null ? suffix : "");
     }
 }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/resources/configuration-test-application.properties b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/resources/configuration-test-application.properties
index fb26fd6217831..53f7e29799191 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/resources/configuration-test-application.properties
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/resources/configuration-test-application.properties
@@ -26,6 +26,8 @@ quarkus.rest-client."io.quarkus.rest.client.reactive.HelloClientWithBaseUri".hos
 quarkus.rest-client."io.quarkus.rest.client.reactive.HelloClientWithBaseUri".connection-ttl=30000
 quarkus.rest-client."io.quarkus.rest.client.reactive.HelloClientWithBaseUri".connection-pool-size=10
 quarkus.rest-client."io.quarkus.rest.client.reactive.HelloClientWithBaseUri".max-redirects=5
+quarkus.rest-client."io.quarkus.rest.client.reactive.HelloClientWithBaseUri".headers.message=hi
+quarkus.rest-client."io.quarkus.rest.client.reactive.HelloClientWithBaseUri".headers.suffix=!
 
 # client identified by a configKey
 quarkus.rest-client.client-prefix.url=http://localhost:${quarkus.http.test-port:8081}/hello
@@ -40,9 +42,12 @@ quarkus.rest-client.client-prefix.hostname-verifier=io.quarkus.rest.client.react
 quarkus.rest-client.client-prefix.connection-ttl=30000
 quarkus.rest-client.client-prefix.connection-pool-size=10
 quarkus.rest-client.client-prefix.max-redirects=5
+quarkus.rest-client.client-prefix.headers.user-agent=MP REST Client
+quarkus.rest-client.client-prefix.headers.foo=bar
 
 # client identified by a quoted prefix
 quarkus.rest-client."quoted-client-prefix".url=http://localhost:${quarkus.http.test-port:8081}/hello
+quarkus.rest-client."quoted-client-prefix".headers.foo=bar
 
 # invalid - unquoted prefix containing dot character will not be read
 quarkus.rest-client.client.prefix.url=http://localhost:${quarkus.http.test-port:8081}/hello
diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java
index bc0106ac8d99c..8131cc7f5de2a 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java
@@ -13,6 +13,7 @@
 import java.security.NoSuchAlgorithmException;
 import java.security.cert.CertificateException;
 import java.util.Locale;
+import java.util.Map;
 import java.util.Optional;
 import java.util.concurrent.TimeUnit;
 
@@ -92,6 +93,14 @@ private void configureCustomProperties(RestClientBuilder builder) {
             int connectionTTLSeconds = connectionTTL.get() / 1000;
             builder.property(QuarkusRestClientProperties.CONNECTION_TTL, connectionTTLSeconds);
         }
+
+        Map<String, String> headers = clientConfigByClassName().headers;
+        if (headers.isEmpty()) {
+            headers = clientConfigByConfigKey().headers;
+        }
+        if ((headers != null) && !headers.isEmpty()) {
+            builder.property(QuarkusRestClientProperties.STATIC_HEADERS, headers);
+        }
     }
 
     private void configureProxy(RestClientBuilder builder) {
diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java
index f80d41ebff3a8..92f48575c7edd 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java
@@ -8,6 +8,7 @@
 import java.security.KeyStoreException;
 import java.security.NoSuchAlgorithmException;
 import java.security.cert.CertificateException;
+import java.util.Collections;
 import java.util.Optional;
 import java.util.concurrent.TimeUnit;
 
@@ -118,6 +119,7 @@ private static RestClientsConfig createSampleConfiguration() {
         clientConfig.connectionTTL = Optional.of(30000); // value in milliseconds
         clientConfig.connectionPoolSize = Optional.of(103);
         clientConfig.maxRedirects = Optional.of(104);
+        clientConfig.headers = Collections.emptyMap();
 
         RestClientsConfig configRoot = new RestClientsConfig();
         configRoot.multipartPostEncoderMode = Optional.of("HTML5");
diff --git a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/api/QuarkusRestClientProperties.java b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/api/QuarkusRestClientProperties.java
index 127924a6ca913..9491d9cf21b87 100644
--- a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/api/QuarkusRestClientProperties.java
+++ b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/api/QuarkusRestClientProperties.java
@@ -22,4 +22,6 @@ public class QuarkusRestClientProperties {
      * The size of the rest client connection pool.
      */
     public static final String CONNECTION_POOL_SIZE = "io.quarkus.rest.client.connection-pool-size";
+
+    public static final String STATIC_HEADERS = "io.quarkus.rest.client.static-headers";
 }
diff --git a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSendRequestHandler.java b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSendRequestHandler.java
index 7909b823f22e7..7595861b54d11 100644
--- a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSendRequestHandler.java
+++ b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSendRequestHandler.java
@@ -281,6 +281,7 @@ private QuarkusMultipartFormUpload setMultipartHeadersAndPrepareBody(HttpClientR
                     "Multipart form upload expects an entity of type MultipartForm, got: " + state.getEntity().getEntity());
         }
         MultivaluedMap<String, String> headerMap = state.getRequestHeaders().asMap();
+        updateRequestHeadersFromConfig(state, headerMap);
         QuarkusMultipartForm multipartForm = (QuarkusMultipartForm) state.getEntity().getEntity();
         multipartForm.preparePojos(state);
 
@@ -307,6 +308,8 @@ private Buffer setRequestHeadersAndPrepareBody(HttpClientRequest httpClientReque
             RestClientRequestContext state)
             throws IOException {
         MultivaluedMap<String, String> headerMap = state.getRequestHeaders().asMap();
+        updateRequestHeadersFromConfig(state, headerMap);
+
         Buffer actualEntity = AsyncInvokerImpl.EMPTY_BUFFER;
         Entity<?> entity = state.getEntity();
         if (entity != null) {
@@ -321,6 +324,15 @@ private Buffer setRequestHeadersAndPrepareBody(HttpClientRequest httpClientReque
         return actualEntity;
     }
 
+    private void updateRequestHeadersFromConfig(RestClientRequestContext state, MultivaluedMap<String, String> headerMap) {
+        Object staticHeaders = state.getConfiguration().getProperty(QuarkusRestClientProperties.STATIC_HEADERS);
+        if (staticHeaders instanceof Map) {
+            for (Map.Entry<String, String> entry : ((Map<String, String>) staticHeaders).entrySet()) {
+                headerMap.putSingle(entry.getKey(), entry.getValue());
+            }
+        }
+    }
+
     private void setVertxHeaders(HttpClientRequest httpClientRequest, MultivaluedMap<String, String> headerMap) {
         MultiMap vertxHttpHeaders = httpClientRequest.headers();
         for (Map.Entry<String, List<String>> entry : headerMap.entrySet()) {