diff --git a/Makefile.pre.in b/Makefile.pre.in
index 0782d95482576a..0b4d9a5240158c 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -2399,6 +2399,7 @@ clean-retain-profile: pycremoval
 	-rm -f Lib/lib2to3/*Grammar*.pickle
 	-rm -f _bootstrap_python
 	-rm -f python.html python*.js python.data
+	-rm -rf $(WASM_STDLIB)
 	-rm -f Programs/_testembed Programs/_freeze_module
 	-rm -f Python/deepfreeze/*.[co]
 	-rm -f Python/frozen_modules/*.h
diff --git a/configure b/configure
index ccbf4fc0b180f7..b5a6e0c51bd524 100755
--- a/configure
+++ b/configure
@@ -6577,7 +6577,13 @@ fi
 $as_echo "$LDLIBRARY" >&6; }
 
 # LIBRARY_DEPS, LINK_PYTHON_OBJS and LINK_PYTHON_DEPS variable
-LIBRARY_DEPS='$(PY3LIBRARY) $(EXPORTSYMS)'
+case $ac_sys_system/$ac_sys_emscripten_target in #(
+  Emscripten/browser) :
+    LIBRARY_DEPS='$(PY3LIBRARY) $(WASM_STDLIB)' ;; #(
+  *) :
+    LIBRARY_DEPS='$(PY3LIBRARY) $(EXPORTSYMS)'
+ ;;
+esac
 LINK_PYTHON_DEPS='$(LIBRARY_DEPS)'
 if test "$PY_ENABLE_SHARED" = 1 || test "$enable_framework" ; then
     LIBRARY_DEPS="\$(LDLIBRARY) $LIBRARY_DEPS"
@@ -7669,14 +7675,14 @@ fi
 case $ac_sys_system/$ac_sys_emscripten_target in #(
   Emscripten/browser) :
 
-    LDFLAGS_NODIST="$(LDFLAGS_NODIST) -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 --preload-file \$(WASM_ASSETS_DIR)"
+    LDFLAGS_NODIST="$LDFLAGS_NODIST -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 --preload-file \$(WASM_ASSETS_DIR)"
     WASM_ASSETS_DIR=".\$(prefix)"
     WASM_STDLIB="\$(WASM_ASSETS_DIR)/local/lib/python\$(VERSION)/os.py"
    ;; #(
   Emscripten/node) :
 
-    LDFLAGS_NODIST="$(LDFLAGS_NODIST) -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 -s NODERAWFS=1 -s EXIT_RUNTIME=1 -s USE_PTHREADS -s PROXY_TO_PTHREAD"
-    CFLAGS_NODIST="$(CFLAGS_NODIST) -pthread"
+    LDFLAGS_NODIST="$LDFLAGS_NODIST -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 -s NODERAWFS=1 -s EXIT_RUNTIME=1 -s USE_PTHREADS -s PROXY_TO_PTHREAD"
+    CFLAGS_NODIST="$CFLAGS_NODIST -pthread"
    ;; #(
   WASI) :
 
@@ -21294,22 +21300,26 @@ $as_echo "yes" >&6; }
 fi
 
 
-case $ac_sys_system in #(
-  AIX) :
+case $ac_sys_system/$ac_sys_emscripten_target in #(
+  AIX/*) :
     py_stdlib_not_available="_scproxy spwd" ;; #(
-  VxWorks*) :
+  VxWorks*/*) :
     py_stdlib_not_available="_scproxy _crypt termios grp" ;; #(
-  Darwin) :
+  Darwin/*) :
     py_stdlib_not_available="ossaudiodev spwd" ;; #(
-  CYGWIN*) :
+  CYGWIN*/*) :
     py_stdlib_not_available="_scproxy nis" ;; #(
-  QNX*) :
+  QNX*/*) :
     py_stdlib_not_available="_scproxy nis" ;; #(
-  FreeBSD*) :
+  FreeBSD*/*) :
     py_stdlib_not_available="_scproxy spwd" ;; #(
-  Emscripten) :
+  Emscripten/browser) :
 
     py_stdlib_not_available="_ctypes _curses _curses_panel _dbm _gdbm _multiprocessing _posixshmem _posixsubprocess _scproxy _tkinter _xxsubinterpreters fcntl grp nis ossaudiodev resource readline spwd syslog termios"
+   ;; #(
+      Emscripten/node) :
+
+    py_stdlib_not_available="_ctypes _curses _curses_panel _dbm _gdbm _scproxy _tkinter nis ossaudiodev spwd syslog"
    ;; #(
   *) :
     py_stdlib_not_available="_scproxy"
diff --git a/configure.ac b/configure.ac
index 89041b205f50d4..300d793ad7dfa4 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1354,7 +1354,10 @@ fi
 AC_MSG_RESULT($LDLIBRARY)
 
 # LIBRARY_DEPS, LINK_PYTHON_OBJS and LINK_PYTHON_DEPS variable
-LIBRARY_DEPS='$(PY3LIBRARY) $(EXPORTSYMS)'
+AS_CASE([$ac_sys_system/$ac_sys_emscripten_target],
+  [Emscripten/browser], [LIBRARY_DEPS='$(PY3LIBRARY) $(WASM_STDLIB)'],
+  [LIBRARY_DEPS='$(PY3LIBRARY) $(EXPORTSYMS)']
+)
 LINK_PYTHON_DEPS='$(LIBRARY_DEPS)'
 if test "$PY_ENABLE_SHARED" = 1 || test "$enable_framework" ; then
     LIBRARY_DEPS="\$(LDLIBRARY) $LIBRARY_DEPS"
@@ -1839,13 +1842,13 @@ fi
 # WASM flags
 AS_CASE([$ac_sys_system/$ac_sys_emscripten_target],
   [Emscripten/browser], [
-    LDFLAGS_NODIST="$(LDFLAGS_NODIST) -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 --preload-file \$(WASM_ASSETS_DIR)"
+    LDFLAGS_NODIST="$LDFLAGS_NODIST -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 --preload-file \$(WASM_ASSETS_DIR)"
     WASM_ASSETS_DIR=".\$(prefix)"
     WASM_STDLIB="\$(WASM_ASSETS_DIR)/local/lib/python\$(VERSION)/os.py"
   ],
   [Emscripten/node], [
-    LDFLAGS_NODIST="$(LDFLAGS_NODIST) -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 -s NODERAWFS=1 -s EXIT_RUNTIME=1 -s USE_PTHREADS -s PROXY_TO_PTHREAD"
-    CFLAGS_NODIST="$(CFLAGS_NODIST) -pthread"
+    LDFLAGS_NODIST="$LDFLAGS_NODIST -s ASSERTIONS=1 -s ALLOW_MEMORY_GROWTH=1 -s NODERAWFS=1 -s EXIT_RUNTIME=1 -s USE_PTHREADS -s PROXY_TO_PTHREAD"
+    CFLAGS_NODIST="$CFLAGS_NODIST -pthread"
   ],
   [WASI], [
     AC_DEFINE([_WASI_EMULATED_SIGNAL], [1], [Define to 1 if you want to emulate signals on WASI])
@@ -6336,14 +6339,14 @@ AC_SUBST(TEST_MODULES)
 dnl Modules that are not available on some platforms
 dnl AIX has shadow passwords, but access is not via getspent()
 dnl VxWorks does not provide crypt() function
-AS_CASE([$ac_sys_system],
-  [AIX], [py_stdlib_not_available="_scproxy spwd"],
-  [VxWorks*], [py_stdlib_not_available="_scproxy _crypt termios grp"],
-  [Darwin], [py_stdlib_not_available="ossaudiodev spwd"],
-  [CYGWIN*], [py_stdlib_not_available="_scproxy nis"],
-  [QNX*], [py_stdlib_not_available="_scproxy nis"],
-  [FreeBSD*], [py_stdlib_not_available="_scproxy spwd"],
-  [Emscripten], [
+AS_CASE([$ac_sys_system/$ac_sys_emscripten_target],
+  [AIX/*], [py_stdlib_not_available="_scproxy spwd"],
+  [VxWorks*/*], [py_stdlib_not_available="_scproxy _crypt termios grp"],
+  [Darwin/*], [py_stdlib_not_available="ossaudiodev spwd"],
+  [CYGWIN*/*], [py_stdlib_not_available="_scproxy nis"],
+  [QNX*/*], [py_stdlib_not_available="_scproxy nis"],
+  [FreeBSD*/*], [py_stdlib_not_available="_scproxy spwd"],
+  [Emscripten/browser], [
     py_stdlib_not_available="m4_normalize([
       _ctypes
       _curses
@@ -6367,6 +6370,23 @@ AS_CASE([$ac_sys_system],
       termios
     ])"
   ],
+  dnl Some modules like _posixsubprocess do not work. We build them anyway
+  dnl so imports in tests do not fail.
+  [Emscripten/node], [
+    py_stdlib_not_available="m4_normalize([
+      _ctypes
+      _curses
+      _curses_panel
+      _dbm
+      _gdbm
+      _scproxy
+      _tkinter
+      nis
+      ossaudiodev
+      spwd
+      syslog
+    ])"
+  ],
   [py_stdlib_not_available="_scproxy"]
 )