diff --git a/requirements/main.in b/requirements/main.in
index 10304bbc0957..73f8dda6eb16 100644
--- a/requirements/main.in
+++ b/requirements/main.in
@@ -26,6 +26,7 @@ kombu[sqs]~=5.2.4  # https://github.com/celery/celery/issues/7070
 mistune
 msgpack
 natsort
+orjson
 packaging>=15.2
 paginate>=0.5.2
 paginate_sqlalchemy
diff --git a/requirements/main.txt b/requirements/main.txt
index 6d71bbc6943f..1d8aebfcdd2c 100644
--- a/requirements/main.txt
+++ b/requirements/main.txt
@@ -808,6 +808,45 @@ natsort==8.1.0 \
     --hash=sha256:c7c1f3f27c375719a4dfcab353909fe39f26c2032a062a8c80cc844eaaca0445 \
     --hash=sha256:f59988d2f24e77b6b56f8a8f882d5df6b3b637e09e075abc67b486d59fba1a4b
     # via -r requirements/main.in
+orjson==3.7.3 \
+    --hash=sha256:0a4d747a43c5c9240968f74737da9f9978840f9b5c86bb578919c4e1adb05142 \
+    --hash=sha256:1594555a73670837a94a42ec21470d30a5cbe430bf1683f491b1f87270aaa305 \
+    --hash=sha256:1b8391a4fb5783fc8cd96f9594d64524204569dec612689e64cabfb6075bffe1 \
+    --hash=sha256:1cd9cd9bb9cee39aca4f7e1079cc3e180ffad0b13342ac3fabf5ff3caf7285bb \
+    --hash=sha256:2cc17eb506613dda54061d956c416720dcd660ef6291ff94a88dcbb857933b2d \
+    --hash=sha256:2efd7561e3a25bf381ee6410c4ca26f3425948074d394fae708bc1b7d2c09100 \
+    --hash=sha256:320c0ffe508a12e83631e8172c29f42af6ba52473f1c6afec0bc99831d3e7cd9 \
+    --hash=sha256:38cb1191aae1f62665750f2457d04a8d7b1d289745b1ff3617f665f24cbab3e7 \
+    --hash=sha256:4205c32a003c732b4fa9c040cd5a0660d87d38a7a97eb8db559d0b22f66bade6 \
+    --hash=sha256:4cb6ea393398e5665fd84f4bff11fff79fe42c40cc4b38afd8241b15aa72e2c3 \
+    --hash=sha256:4d10459578c139f428adedff41a78afde7034e277979cbb67b2d0584ddaff320 \
+    --hash=sha256:5738ab3283e75953b2aba549ebe7061cb883b2fd2d281097009242b3936c0114 \
+    --hash=sha256:6998ff27b9b9aaa4906f6ad40c6c973339c772143f56e8e920f4843fd6c04e75 \
+    --hash=sha256:6c59aec36cb77634dd218789bffa801f265a9522cf6311573ae4202a6888abca \
+    --hash=sha256:6c7eca150d9d7dedf405d82c346105d6475e57789f3c3b4e0d12d59def94cb30 \
+    --hash=sha256:6ca694b989da69d31f129992bc00310b704adcbde8b3a24b571d883d2783a8e1 \
+    --hash=sha256:716c8f7eb39128067355bd1bc5e66156934d70295f5c62786a89af9c3f50c4d7 \
+    --hash=sha256:7406f8d163e7e7f358b34016e828f6b5ce15e6f7f0de3f82089a26ba1b41d75e \
+    --hash=sha256:7592bc8c2009a7ee39ec1a022bb711f23bf74b9c49ffbe93479cdac16842b5ca \
+    --hash=sha256:837bcaefb9ba61d40587d25052e3c74652e853108af6e2bc172c001b5f2ffd3e \
+    --hash=sha256:863b7f13d1fd05b65ba4926f017b0d301d6b898db4ebcb19609af111f77a803c \
+    --hash=sha256:8ef7696c3771dd11df5a45922794ad17b0421bfb5ba07832b960b653225ca739 \
+    --hash=sha256:940184f159f6be00e2f4320fdeebe6b842228db26db679c7cad5654818643938 \
+    --hash=sha256:95fd418e3e93305b728e056fa35096b70261b63ba6df404a8f6af5694b27de20 \
+    --hash=sha256:99b9c2ed45c06c77a990cd5d37bf43ac815fcb5cc36a2351629d270673ea4b94 \
+    --hash=sha256:9e68c01d576aaf3d83b3a18a3d2139d2cbfebc415264d7054d37d7fd8292bd08 \
+    --hash=sha256:9f2248d54957a63cf861285ea46f89ae79853e84ee26593560e8d53892a6b652 \
+    --hash=sha256:a4eb1ea1afe6494af75e61bf8bbca251e8e4883f1c235652e509e86e0eaf23b6 \
+    --hash=sha256:a9895be514b3aad76f81c739b7348c31f913971923ac71e0a35443abe6696a6d \
+    --hash=sha256:a9d68a29111d9e2e9ac45eb339ae4083a754fc9deba3270ef573c87c64e75e3b \
+    --hash=sha256:ade22b22f2d4baafcdcac63a66893250b51e7601e16f2c93bab29b30d233c5ac \
+    --hash=sha256:ae229eef7a5a418011627b283d7fe0316d05fef65e88ae6623eecd5c6c701726 \
+    --hash=sha256:b2dadb4c0e2c4aa81f5bf20d58bd3b742e55c1142dd2bde5707749e77e3a9ad1 \
+    --hash=sha256:b500e4b1a6e8d93e226c55848419146365b57000f0afb1766475cb0a5b913aac \
+    --hash=sha256:c06d6162694a83ba2f3a5fdceca9f8a7b30cae78e6e9651c8bdfb33cae3b95a3 \
+    --hash=sha256:c70e650324ce3efd65c9452c3e59c40f41e28a16a84ed4a56cb4ed84b4d788db \
+    --hash=sha256:e17adc831c2a909a31b732e59973b6162d969f2e742a7c2428e62cc5fd65e00e
+    # via -r requirements/main.in
 packaging==21.3 \
     --hash=sha256:dd47c42927d89ab911e606518907cc2d3a1f38bbd026385970643f9c5b8ecfeb \
     --hash=sha256:ef103e05f519cdc783ae24ea4e2e0f508a9c99b2d4969652eed6a2e1ea5bd522
diff --git a/tests/unit/test_config.py b/tests/unit/test_config.py
index f5d5c590e979..98817a26657e 100644
--- a/tests/unit/test_config.py
+++ b/tests/unit/test_config.py
@@ -14,6 +14,7 @@
 
 from unittest import mock
 
+import orjson
 import pretend
 import pytest
 
@@ -443,7 +444,10 @@ def __init__(self):
     ]
 
     assert json_renderer_cls.calls == [
-        pretend.call(sort_keys=True, separators=(",", ":"))
+        pretend.call(
+            serializer=orjson.dumps,
+            option=orjson.OPT_SORT_KEYS | orjson.OPT_APPEND_NEWLINE,
+        )
     ]
 
     assert xmlrpc_renderer_cls.calls == [pretend.call(allow_none=True)]
diff --git a/warehouse/config.py b/warehouse/config.py
index b54ff0f1aa31..0c990956a0be 100644
--- a/warehouse/config.py
+++ b/warehouse/config.py
@@ -15,6 +15,7 @@
 import os
 import shlex
 
+import orjson
 import transaction
 
 from pyramid import renderers
@@ -451,7 +452,13 @@ def configure(settings=None):
 
     # We want to configure our JSON renderer to sort the keys, and also to use
     # an ultra compact serialization format.
-    config.add_renderer("json", renderers.JSON(sort_keys=True, separators=(",", ":")))
+    config.add_renderer(
+        "json",
+        renderers.JSON(
+            serializer=orjson.dumps,
+            option=orjson.OPT_SORT_KEYS | orjson.OPT_APPEND_NEWLINE,
+        ),
+    )
 
     # Configure retry support.
     config.add_settings({"retry.attempts": 3})