diff --git a/newsfragments/4094.bugfix.rst b/newsfragments/4094.bugfix.rst
new file mode 100644
index 0000000000..8c73eaedbf
--- /dev/null
+++ b/newsfragments/4094.bugfix.rst
@@ -0,0 +1,2 @@
+Replaced hardcoded numeric values with :obj:`dis.opmap`,
+fixing problem with 3.13.0a1.
diff --git a/setuptools/depends.py b/setuptools/depends.py
index 180e820459..42907d9bd4 100644
--- a/setuptools/depends.py
+++ b/setuptools/depends.py
@@ -142,9 +142,9 @@ def extract_constant(code, symbol, default=-1):
 
     name_idx = list(code.co_names).index(symbol)
 
-    STORE_NAME = 90
-    STORE_GLOBAL = 97
-    LOAD_CONST = 100
+    STORE_NAME = dis.opmap['STORE_NAME']
+    STORE_GLOBAL = dis.opmap['STORE_GLOBAL']
+    LOAD_CONST = dis.opmap['LOAD_CONST']
 
     const = default