diff --git a/news/5235.doc.rst b/news/5235.doc.rst
new file mode 100644
index 0000000000..54c3dd93c6
--- /dev/null
+++ b/news/5235.doc.rst
@@ -0,0 +1 @@
+Add documentation for environment variables the configure pipenv.
diff --git a/pipenv/core.py b/pipenv/core.py
index 7583e396eb..40021ee186 100644
--- a/pipenv/core.py
+++ b/pipenv/core.py
@@ -146,7 +146,8 @@ def load_dot_env(project, as_dict=False, quiet=False):
                     err=True,
                 )
             dotenv.load_dotenv(dotenv_file, override=True)
-        project.s.initialize()
+
+            project.s = environments.Setting()
 
 
 def cleanup_virtualenv(project, bare=True):
diff --git a/pipenv/environments.py b/pipenv/environments.py
index 7f1eb8bfae..7e08876203 100644
--- a/pipenv/environments.py
+++ b/pipenv/environments.py
@@ -107,19 +107,20 @@ def normalize_pipfile_path(p):
 
 
 class Setting:
+    """
+    Control various settings of pipenv via environment variables.
+    """
+
     def __init__(self) -> None:
-        self.USING_DEFAULT_PYTHON = True
-        self.initialize()
 
-    def initialize(self):
+        self.USING_DEFAULT_PYTHON = True
+        """Use the default Python"""
 
+        #: Location for Pipenv to store it's package cache.
+        #: Default is to use appdir's user cache directory.
         self.PIPENV_CACHE_DIR = os.environ.get(
             "PIPENV_CACHE_DIR", user_cache_dir("pipenv")
         )
-        """Location for Pipenv to store it's package cache.
-
-        Default is to use appdir's user cache directory.
-        """
 
         # Tells Pipenv which Python to default to, when none is provided.
         self.PIPENV_DEFAULT_PYTHON_VERSION = os.environ.get(