diff --git a/README.md b/README.md
index 8baa114a6..18f93cc40 100644
--- a/README.md
+++ b/README.md
@@ -112,6 +112,9 @@ You have a few options here:
 3. Run the command in a [virtualenv](https://virtualenv.pypa.io/en/latest/)
    local to a specific project working set.
 
+For notes about installing and using on non-x86 systems such as Raspberry Pi, see the
+[relevant documentation](docs/installing_on_non_x86.md).
+
 ### libusb installation
 
 [pyusb](https://github.com/pyusb/pyusb) and its backend library [libusb](https://libusb.info/) are
diff --git a/docs/README.md b/docs/README.md
index 9b01535af..d27e1d3fd 100644
--- a/docs/README.md
+++ b/docs/README.md
@@ -13,6 +13,7 @@
 - [Debugging multicore devices](multicore_debug.md)
 - [Introduction to the pyOCD Python API](python_api.md)
 - [Python API examples](api_examples.md)
+- [Installing on non-x86 platforms](installing_on_non_x86.md)
 
 ### Developer documentation
 
diff --git a/docs/installing_on_non_x86.md b/docs/installing_on_non_x86.md
new file mode 100644
index 000000000..8cd5de8f2
--- /dev/null
+++ b/docs/installing_on_non_x86.md
@@ -0,0 +1,55 @@
+Installing on non-x86 platforms
+===============================
+
+pyOCD itself is pure Python and should run on any platform with a modern Python installation.
+However, it has several dependencies with binary backends that cause trouble on non-x86 platforms or
+alternative operating systems (i.e., not macOS, Linux, or Windows). The most common "non-standard"
+system that users would like to run pyOCD on is the Raspberry Pi, as well as similar, Arm-based
+single-board computers.
+
+
+## cmsis-pack-manager
+
+The main dependency that causes trouble is
+[cmsis-pack-manager](https://github.com/armmbed/cmsis-pack-manager/). It has a backend written in
+the Rust language to greatly improve performance. Unfortunately, wheels are not available for
+non-x86 systems. And, worse, the Rust compiler runs out of memory and dies when attempting to build
+on small platforms such as the Raspberry Pi. (Cross-compilation may be an option but has not been
+sufficiently investigated.)
+
+The good news is that cmsis-pack-manager is optional for pyOCD. Although it is listed as a required
+dependency in `setup.py` (so the vast majority of users benefit from it), pyOCD can run without it
+with minimal loss of functionality. The `pack` subcommand is disabled, which removes automatic
+CMSIS-Pack download and management. But you can still use CMSIS-Packs manually with the `--pack`
+option, as described in [Target support](target_support.md).
+
+To install pyOCD on such a system, you need to use the `pip install --no-deps` option. This will
+install the core pyOCD package only, so all additional requirements must be manually installed.
+You can either run `pip install` with an explicit list of the requirements from `setup.py`, or
+copy those requirements to a requirements text file and run `pip install -r reqs.txt`. Of course,
+be sure to exclude cmsis-pack-manager! (The requirements are not listed here lest they get out of
+sync with `setup.py`.)
+
+Once pyOCD is successfully installed, you will need to run it as a module using the `python`
+executable as `python -mpyocd` rather than running the `pyocd` executable directly. This is because
+the `pyocd` executable, which is auto-generated by the install process, verifies dependencies and
+will error out due to the missing cmsis-pack-manager. But when run through `python`, dependencies
+are not checked and pyOCD can handle the lack of cmsis-pack-manager gracefully.
+
+
+## USB interfaces
+
+The other dependencies that might be problematic are those for USB communications. pyOCD uses
+three USB libraries:
+
+- pyusb and libusb: CMSIS-DAPv1 on Linux, CMSIS-DAPv2 and STLink on all OSes
+- hidapi: CMSIS-DAPv1 on macOS
+- pywinusb: CMSIS-DAPv1 on Windows
+
+Thankfully, libusb is provided by default on most Linux systems, including Raspberry Pi and similar
+platforms. So on almost all platforms, USB is not a real problem.
+
+If you are using an alternative OS, you may have trouble finding a functional USB library. In this
+case, the options would be to port libusb and/or hidapi to your OS, or even to extend pyOCD with
+support for another USB interface package.
+