diff --git a/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.hpp b/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.hpp
index 21c44dd00279e3..1270ebf215bccd 100644
--- a/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.hpp
+++ b/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.hpp
@@ -149,6 +149,7 @@ void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_ProcessThreadActivity
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_HaveRouteToAddress(const Inet::IPAddress & destAddr)
 {
+    VerifyOrReturnValue(mOTInst, false);
     bool res = false;
 
     // Lock OpenThread
@@ -233,6 +234,7 @@ void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_OnPlatformEvent(const
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_IsThreadEnabled(void)
 {
+    VerifyOrReturnValue(mOTInst, false);
     otDeviceRole curRole;
 
     Impl()->LockThreadStack();
@@ -245,6 +247,7 @@ bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_IsThreadEnabled(void)
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetThreadEnabled(bool val)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     otError otErr = OT_ERROR_NONE;
 
     Impl()->LockThreadStack();
@@ -279,6 +282,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetThreadEnable
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetThreadProvision(ByteSpan netInfo)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     otError otErr = OT_ERROR_FAILED;
     otOperationalDatasetTlvs tlvs;
 
@@ -305,6 +309,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetThreadProvis
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_IsThreadProvisioned(void)
 {
+    VerifyOrReturnValue(mOTInst, false);
     bool provisioned;
 
     Impl()->LockThreadStack();
@@ -317,6 +322,7 @@ bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_IsThreadProvisioned(v
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetThreadProvision(Thread::OperationalDataset & dataset)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     VerifyOrReturnError(Impl()->IsThreadProvisioned(), CHIP_ERROR_INCORRECT_STATE);
     otOperationalDatasetTlvs datasetTlv;
 
@@ -336,6 +342,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetThreadProvis
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_IsThreadAttached(void)
 {
+    VerifyOrReturnValue(mOTInst, false);
     otDeviceRole curRole;
 
     Impl()->LockThreadStack();
@@ -380,6 +387,7 @@ template <class ImplClass>
 CHIP_ERROR
 GenericThreadStackManagerImpl_OpenThread<ImplClass>::_StartThreadScan(NetworkCommissioning::ThreadDriver::ScanCallback * callback)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 #if CHIP_CONFIG_ENABLE_ICD_SERVER
     otLinkModeConfig linkMode;
@@ -488,6 +496,7 @@ void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_OnNetworkScanFinished
 template <class ImplClass>
 ConnectivityManager::ThreadDeviceType GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetThreadDeviceType(void)
 {
+    VerifyOrReturnValue(mOTInst, ConnectivityManager::kThreadDeviceType_NotSupported);
     ConnectivityManager::ThreadDeviceType deviceType;
 
     Impl()->LockThreadStack();
@@ -524,6 +533,7 @@ template <class ImplClass>
 CHIP_ERROR
 GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetThreadDeviceType(ConnectivityManager::ThreadDeviceType deviceType)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR err = CHIP_NO_ERROR;
     otLinkModeConfig linkMode;
 
@@ -612,6 +622,7 @@ GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetThreadDeviceType(Connec
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_HaveMeshConnectivity(void)
 {
+    VerifyOrReturnValue(mOTInst, false);
     bool res;
     otDeviceRole curRole;
 
@@ -660,6 +671,7 @@ bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::_HaveMeshConnectivity(
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetAndLogThreadStatsCounters(void)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR err = CHIP_NO_ERROR;
     otError otErr;
     otOperationalDataset activeDataset;
@@ -754,6 +766,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetAndLogThread
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetAndLogThreadTopologyMinimal(void)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR err = CHIP_NO_ERROR;
 
 #if CHIP_PROGRESS_LOGGING
@@ -822,6 +835,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetAndLogThread
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetAndLogThreadTopologyFull()
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR err = CHIP_NO_ERROR;
 
 #if CHIP_PROGRESS_LOGGING
@@ -991,6 +1005,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetAndLogThread
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetPrimary802154MACAddress(uint8_t * buf)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     const otExtAddress * extendedAddr = otLinkGetExtendedAddress(mOTInst);
     memcpy(buf, extendedAddr, sizeof(otExtAddress));
     return CHIP_NO_ERROR;
@@ -999,6 +1014,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetPrimary80215
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetExternalIPv6Address(chip::Inet::IPAddress & addr)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     const otNetifAddress * otAddresses = otIp6GetUnicastAddresses(mOTInst);
 
     // Look only for the global unicast addresses, not internally assigned by Thread.
@@ -1034,6 +1050,7 @@ void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_ResetThreadNetworkDia
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_GetPollPeriod(uint32_t & buf)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     Impl()->LockThreadStack();
     buf = otLinkGetPollPeriod(mOTInst);
     Impl()->UnlockThreadStack();
@@ -1107,6 +1124,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::DoInit(otInstanc
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::IsThreadAttachedNoLock(void)
 {
+    VerifyOrReturnValue(mOTInst, false);
     otDeviceRole curRole = otThreadGetDeviceRole(mOTInst);
     return (curRole != OT_DEVICE_ROLE_DISABLED && curRole != OT_DEVICE_ROLE_DETACHED);
 }
@@ -1114,6 +1132,7 @@ bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::IsThreadAttachedNoLock
 template <class ImplClass>
 bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::IsThreadInterfaceUpNoLock(void)
 {
+    VerifyOrReturnValue(mOTInst, false);
     return otIp6IsEnabled(mOTInst);
 }
 
@@ -1121,6 +1140,7 @@ bool GenericThreadStackManagerImpl_OpenThread<ImplClass>::IsThreadInterfaceUpNoL
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetPollingInterval(System::Clock::Milliseconds32 pollingInterval)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR err = CHIP_NO_ERROR;
     Impl()->LockThreadStack();
 
@@ -1173,6 +1193,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetPollingInter
 template <class ImplClass>
 void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_ErasePersistentInfo(void)
 {
+    VerifyOrReturn(mOTInst);
     ChipLogProgress(DeviceLayer, "Erasing Thread persistent info...");
     Impl()->LockThreadStack();
     otThreadSetEnabled(mOTInst, false);
@@ -1205,6 +1226,7 @@ void GenericThreadStackManagerImpl_OpenThread<ImplClass>::OnJoinerComplete(otErr
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_JoinerStart(void)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 
     Impl()->LockThreadStack();
@@ -1254,6 +1276,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_JoinerStart(voi
 template <class ImplClass>
 void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_UpdateNetworkStatus()
 {
+    VerifyOrReturn(mOTInst);
     // Thread is not enabled, then we are not trying to connect to the network.
     VerifyOrReturn(ThreadStackMgrImpl().IsThreadEnabled() && mpStatusChangeCallback != nullptr);
 
@@ -1450,6 +1473,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_AddSrpService(c
                                                                                const Span<const Dnssd::TextEntry> & aTxtEntries,
                                                                                uint32_t aLeaseInterval, uint32_t aKeyLeaseInterval)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error                         = CHIP_NO_ERROR;
     typename SrpClient::Service * srpService = nullptr;
     size_t entryId                           = 0;
@@ -1552,6 +1576,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_AddSrpService(c
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_RemoveSrpService(const char * aInstanceName, const char * aName)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error                         = CHIP_NO_ERROR;
     typename SrpClient::Service * srpService = nullptr;
 
@@ -1602,6 +1627,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_InvalidateAllSr
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_RemoveInvalidSrpServices()
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 
     VerifyOrReturnError(mSrpClient.mIsInitialized, CHIP_ERROR_UNINITIALIZED);
@@ -1636,6 +1662,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_RemoveInvalidSr
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_ClearAllSrpHostAndServices()
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
     Impl()->LockThreadStack();
     if (!mIsSrpClearAllRequested)
@@ -1656,6 +1683,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_ClearAllSrpHost
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetupSrpHost(const char * aHostName)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 
     VerifyOrReturnError(mSrpClient.mIsInitialized, CHIP_ERROR_UNINITIALIZED);
@@ -1684,6 +1712,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_SetupSrpHost(co
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_ClearSrpHost(const char * aHostName)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 
     Impl()->LockThreadStack();
@@ -1798,6 +1827,7 @@ CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::FromOtDnsRespons
 template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::ResolveAddress(intptr_t context, otDnsAddressCallback callback)
 {
+    VerifyOrReturnError(ThreadStackMgrImpl().OTInstance(), CHIP_ERROR_INCORRECT_STATE);
     DnsResult * dnsResult = reinterpret_cast<DnsResult *>(context);
 
     ThreadStackMgrImpl().LockThreadStack();
@@ -1952,6 +1982,7 @@ template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_DnsBrowse(const char * aServiceName, DnsBrowseCallback aCallback,
                                                                            void * aContext)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 
     Impl()->LockThreadStack();
@@ -2062,6 +2093,7 @@ template <class ImplClass>
 CHIP_ERROR GenericThreadStackManagerImpl_OpenThread<ImplClass>::_DnsResolve(const char * aServiceName, const char * aInstanceName,
                                                                             DnsResolveCallback aCallback, void * aContext)
 {
+    VerifyOrReturnError(mOTInst, CHIP_ERROR_INCORRECT_STATE);
     CHIP_ERROR error = CHIP_NO_ERROR;
 
     Impl()->LockThreadStack();